Clinical and pharmacological group: & nbsp

Antimicrobial, antiparasitic and anthelmintic agents

Included in the formulation
АТХ:

V.03.A   Other different drugs

Pharmacodynamics:

It has the ability to specifically lyse the Klebsiella pneumonia bacteria.

Pharmacokinetics:

Not described.

Indications:

Treatment and prevention of diseases caused by bacteria Klebsiella pneumonia, as part of complex therapy:

- Diseases of the gastrointestinal tract (gastroenterocolitis, cholecystitis, pancreatitis, intestinal dysbacteriosis);

- Inflammatory diseases of newborns and young children (gastroenterocolitis, intestinal dysbacteriosis, omphalitis, pemphigus, pyoderma, septicemia and septicopyemia of various localization);

- surgical infections (suppuration of wounds, purulent skin lesions, burns, peritonitis, pleurisy, mastitis, osteomyelitis, abscess);

- urogenital infections (cystitis, pyelonephritis, urethritis, endometritis, vulvitis, bartholinitis, colpitis, salpingo-oophoritis);

- purulent inflammatory diseases of the ear, throat, nose, sinuses of the nose, mouth, pharynx, larynx, bronchi, lungs and pleura (otitis, angina, pharyngitis, laryngitis, stomatitis, periodontitis, maxillary sinusitis, frontalitis, bronchitis, pneumonia, pleurisy);

- post-traumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcer and iridocyclitis;

- Prevention of nosocomial infections caused by Klebsiella.

VII.H10-H13.H10.4   Chronic conjunctivitis

VII.H15-H22.H16.0   Corneal ulcer

VII.H15-H22.H20.0   Acute and subacute iridocyclitis

VII.H15-H22.H20.1   Chronic iridocyclitis

VIII.H65-H75.H66.4   Purulent otitis media, unspecified

VIII.H65-H75.H66   Purulent and unspecified otitis media

XI.K80-K87.K85   Acute pancreatitis

X.J00-J06.J04   Acute laryngitis and tracheitis

X.J00-J06.J01   Acute Sinusitis

XII.L00-L08.L03   Phlegmon

X.J85-J86.J86   Pythothrace

X.J30-J39.J31   Chronic rhinitis, nasopharyngitis and pharyngitis

XII.L00-L08.L08.0   Pyoderma

XIII.M86-M90.M86   Osteomyelitis

XIV.N30-N39.N30   Cystitis

XIV.N30-N39.N34   Urethritis and urethral syndrome

XVI.P35-P39.P38   Omphalitis of a newborn with little or no bleeding

Contraindications:Individual intolerance.
Carefully:

No data.

Pregnancy and lactation:

Action category for the fetus by Food and Drug Administration (US Food and Drug Administration) - not determined.

The use of this drug during pregnancy and during breast-feeding is possible in the presence of infections caused by phage-sensitive strains of Klebsiella (on the recommendation of a doctor).

Adequate and well-controlled studies on humans and animals have not been conducted. There is no information on the penetration into breast milk.

Dosing and Administration:

Inside.Enterocolitis, intestinal dysbacteriosis - 3 times a day for 1 hour before meals for 7-15 days. For 1 reception up to 6 months - 5 ml, 6-12 months - 10 ml, from 1 to 3 years - 15 ml, from 3 to 8 years - 20 ml, from 8 years and older - 30 ml. Cystitis, pyelonephritis, urethritis - within 10-20 days.

Rectal once a day (in the form of an enema) in combination with a double intake. For 1 reception up to 6 months - 10 ml, 6-12 months - 20 ml, from 1 to 3 years - 30 ml, from 3 to 8 years - 40 ml, from 8 years and older - 50 ml.

Local for 7-20 days with therapy of purulent-inflammatory diseases with localized lesions in combination with ingestion. In the case of treatment of the purulent focus cavity with chemical antiseptics, before using the bacteriophage, wash the cavity with sterile 0.9% NaCl solution.

Purulent wounds - in the form of irrigation, applications, bandages, introduction through drainage at least 1 time per day. With abscesses after opening and removal of purulent contents, the drug is administered in an amount less than the volume of the removed pus. In the drained cavity every day, once - 20-200 ml.

Osteomyelitis - 10-30 ml in the wound cavity through the turunda, drainage.

Purulent-inflammatory gynecological diseases - 5-10 ml daily once a day in the vagina cavity, the uterus.

Purulent-inflammatory diseases of ENT organs - 2-10 ml 1-3 times a day in the cavity of the middle ear, nose.Bacteriophage is used to rinse, rinse, instill, inject wetted turund (leaving them for 1 hour).

Cystitis, pyelonephritis, urethritis - 20-50 ml in the bladder and 5-7 ml in the renal pelvis through the cystostomy or nephrostomy.

Children up to 6 months. Sepsis, enterocolitis of newborns, including premature infants, 2-3 times a day in the form of suppositories or high enemas (through a gas pipe or catheter). In the absence of vomiting and regurgitation of the drug is used inside, mixing with breast milk. A combination of rectal and oral administration of the drug is possible. The course of treatment - 5-15 days, with recurrent course of the disease, it is possible to conduct repeated courses of treatment. For the prevention of sepsis and enterocolitis with intrauterine infection or the danger of nosocomial infection in newborns, the klebsifag is used in the form of suppositories or enemas 2 times a day for 5-7 days.

Omphalitis, pyoderma, infected wounds - 2 times a day every day in the form of an application (gauze napkin moistened with a bacteriophage and put on the umbilical wound or the affected area of ​​the skin).

Side effects:

Reactions to the drug have not been established.

Overdose:

Not described.

Interaction:

The use of the drug is possible in combination with other drugs, including antibiotics.

Special instructions:

It is not suitable for use in cases of turbidity, presence of flakes, absence of marking and expired shelf life.

An important condition for effective phage therapy is the preliminary determination of the pathogenicity of the pathogen.

Instructions
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