Clinical and pharmacological group: & nbsp

Antimicrobial, antiparasitic and anthelmintic agents

Included in the formulation
АТХ:

V.03.A   Other different drugs

Pharmacodynamics:

It has the ability to specifically lyse bacteria of enteropathogenic E. coli.

Pharmacokinetics:

Not described.

Indications:

Treatment and prevention of diseases caused by bacteria Escherichia coli, as part of complex therapy:

- Diseases of the ear, throat, nose, respiratory tract and lungs (inflammation of the sinuses of the nose, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);

- surgical infections (suppuration of wounds, burns, abscess, phlegmon, furuncles, carbuncles, hydradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis);

- urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis);

- enteral infections (gastroenterocolitis, cholecystitis), intestinal dysbacteriosis;

- generalized septic diseases;

- purulent-inflammatory diseases of newborns (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.);

- other diseases caused by E. coli.

With the preventive purpose, the drug is used for the treatment of postoperative and freshly infected wounds, as well as for the prevention of nosocomial infections due to epidemic indications.

I.A00-A09.A04.0   Enteropathogenic infection caused by Escherichia coli

Contraindications:Hypersensitivity to the components of the drug.
Carefully:

No data.

Pregnancy and lactation:

Action category for the fetus by Food and Drug Administration (US Food and Drug Administration) - not determined.

The use of this medication during pregnancy and during breast-feeding is possible in the presence of infections caused by phagosensitive strains of bacteria (on the recommendation of a doctor).

Adequate and well-controlled studies on humans and animals have not been conducted. There is no information on the penetration into breast milk.

Dosing and Administration:

Inside. Enterocolitis, diseases of internal organs, intestinal dysbacteriosis - 3 times a day for 1 hour before meals. For 1 reception up to 6 months - 5 ml, 6-12 months - 10 ml, from 1 to 3 years - 15 ml, from 3 to 8 years - 20 ml, from 8 years and older - 30 ml.

Rectal once a day (in the form of an enema) in combination with a double intake. For 1 dose up to 6 months - 10 ml, 6-12 months - 20 ml, from 1 to 3 years - 30 ml, from 3 to 8 years - 40 ml, from 8 years and older in enema - 50 ml.

Local for 7-20 days with therapy of purulent-inflammatory diseases with localized lesions.

In the case of treatment of the purulent focus cavity with chemical antiseptics, before using the bacteriophage, wash the cavity with sterile 0.9% NaCl solution.

Purulent wounds - in the form of irrigation, applications, bandages, introduction through drainage at least 1 time per day. With abscesses after opening and removal of purulent contents, the drug is administered in an amount less than the volume of the removed pus. In drained cavities daily 1 time a day - 20-200 ml.

Osteomyelitis - 10-20 ml in the wound cavity through the turunda, drainage.

Introduction to the cavity (pleural, articular and other limited cavities) - up to 100 ml of bacteriophage, leaving capillary drainage, through which for several days the bacteriophage is re-introduced.

Purulent-inflammatory gynecological diseases - 5-10 ml daily once a day in the vagina cavity, the uterus. Purulent-inflammatory diseases of ENT organs - 2-10 ml 1-3 times a day in the cavity of the middle ear, nose. Bacteriophage is used to rinse, rinse, instill, inject wetted turund (leaving them for 1 hour).

Cystitis, pyelonephritis, urethritis - 20-50 ml in the bladder and 5-7 ml in the renal pelvis through the cystostomy or nephrostomy.

Children up to 6 months.Sepsis, enterocolitis of newborns, including premature infants, 2-3 times a day in the form of high enemas (through a gas pipe or catheter). In the absence of vomiting and regurgitation of the drug is used inside, mixing with breast milk. A combination of rectal and oral administration of the drug is possible. The course of treatment - 5-15 days, with recurrent course of the disease, it is possible to conduct repeated courses of treatment. For the prevention of sepsis and enterocolitis with intrauterine infection or the risk of nosocomial infection in newborns, the bacteriophage is applied as an enema 2 times a day for 5-7 days.

Omphalitis, pyoderma, infected wounds - 2 times a day every day in the form of an application (gauze napkin moistened with a bacteriophage and put on the umbilical wound or the affected area of ​​the skin).

Side effects:

Reactions to the drug have not been established.

Overdose:

Not described.

Interaction:

The use of a bacteriophage does not exclude the use of other antibacterial drugs.

Special instructions:

It is not suitable for use in cases of turbidity, presence of flakes, absence of marking and expired shelf life.

An important condition for effective phage therapy is the preliminary determination of the pathogenicity of the pathogen.

Instructions
Up