Clinical and pharmacological group: & nbsp

Antimicrobial, antiparasitic and anthelmintic agents

Included in the formulation
АТХ:

V.03.A   Other different drugs

Pharmacodynamics:

It has the ability to specifically lyse bacterium Pseudomonas aeruginosa.

Pharmacokinetics:

Not described.

Indications:

Pyoinflammatory diseases caused by streptococci: ENT organs, respiratory tract, lungs (sinusitis, otitis, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy) and gastrointestinal tract (gastroenterocolitis, cholecystitis, intestinal dysbacteriosis); surgical infections (purulent wounds, burn, mastitis, abscess, phlegmon, carbuncle, hydradenitis, panaritium, paraproctitis, bursitis, osteomyelitis); urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis); purulent-inflammatory diseases of newborns and infants (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis); generalized septic diseases. For prophylaxis - treatment of postoperative and freshly infected wounds, as well as for the prevention of nosocomial infections due to epidemic indications.

XI.K80-K87.K85   Acute pancreatitis

X.J00-J06.J03   Acute tonsillitis

X.J00-J06.J01   Acute Sinusitis

X.J85-J86.J85   Abscess of the lung and mediastinum

XII.L00-L08.L03   Phlegmon

XII.L00-L08.L08.0   Pyoderma

XIII.M86-M90.M86   Osteomyelitis

XIV.N30-N39.N34   Urethritis and urethral syndrome

Contraindications:

Hypersensitivity.

Carefully:

No data.

Pregnancy and lactation:

Action category for the fetus by Food and Drug Administration (US Food and Drug Administration) - not determined.

It is possible to use a Pseudomonas bacteriophage in pregnant women as prescribed by a doctor with a dose. There is no information on the penetration into breast milk.

Dosing and Administration:

Inside. Enterocolitis, diseases of internal organs, intestinal dysbacteriosis - 3 times a day for 1 hour before meals. For 1 reception up to 6 months - 5 ml, 6-12 months - 10 ml, from 1 to 3 years - 15 ml, from 3 to 8 years - 20 ml, from 8 years and older - 30 ml.

Rectal once a day (in the form of an enema) in combination with a double intake. For 1 dose up to 6 months - 10 ml, 6-12 months - 20 ml, from 1 to 3 years - 30 ml, from 3 to 8 years - 40 ml, from 8 years and older in enema - 50 ml.

Local for 7-20 days with therapy of purulent-inflammatory diseases with localized lesions.

In the case of treatment of the purulent focus cavity with chemical antiseptics, before using the bacteriophage, wash the cavity with sterile 0.9% NaCl solution.

Purulent wounds - in the form of irrigation, applications, bandages, introduction through drainage at least 1 time per day.With abscesses after opening and removal of purulent contents, the drug is administered in an amount less than the volume of the removed pus. In drained cavities daily 1 time a day - 20-200 ml.

Osteomyelitis - 10-20 ml in the wound cavity through the turunda, drainage.

Introduction to the cavity (pleural, articular and other limited cavities) - up to 100 ml of bacteriophage, leaving capillary drainage, through which for several days the bacteriophage is re-introduced.

Purulent-inflammatory gynecological diseases - 5-10 ml daily once a day in the vagina cavity, the uterus.

Purulent-inflammatory diseases of ENT organs - 2-10 ml 1-3 times a day in the cavity of the middle ear, nose. Bacteriophage is used to rinse, rinse, instill, inject wetted turund (leaving them for 1 hour).

Cystitis, pyelonephritis, urethritis - 20-50 ml in the bladder and 5-7 ml in the renal pelvis through the cystostomy or nephrostomy.

Children up to 6 months. Sepsis, enterocolitis of newborns, including premature infants, 2-3 times a day in the form of high enemas (through a gas pipe or catheter). In the absence of vomiting and regurgitation of the drug is used inside, mixing with breast milk. A combination of rectal and oral administration of the drug is possible.The course of treatment - 5-15 days, with recurrent course of the disease, it is possible to conduct repeated courses of treatment. For the prevention of sepsis and enterocolitis with intrauterine infection or the risk of nosocomial infection in newborns, the bacteriophage is applied as an enema 2 times a day for 5-7 days.

Omphalitis, pyoderma, infected wounds - 2 times a day every day in the form of an application (gauze napkin moistened with a bacteriophage and put on the umbilical wound or the affected area of ​​the skin).

Side effects:

Allergic reactions.

Overdose:

Not described.

Interaction:

It is possible to carry out combined treatment in combination with antibiotics, treatment with synergic bacteriophage does not exclude the use of other medications.

Special instructions:

An important condition for effective phage therapy is the preliminary determination of the pathogenicity of the pathogen.

Instructions
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