Lactulose - a synthetic disaccharide consisting of galactose and fructose. There are no hydrolases available for cleavage of the disaccharide to the corresponding monosaccharides. Therefore, when administered orally lactulose practically not metabolized, not absorbed in the stomach and small intestine and unchanged enters the large intestine.
Under the influence of disaccharidases, the microflora of the large intestine lactulose fermented to monosaccharides, and then to short-chain carboxylic acids. Bacterial transformation of lactulose leads to a decrease in the pH of the intestinal contents, accumulation of short chain fatty acids and increased peristalsis. Short-chain carboxylic acids reduce the pH level in the large intestine, which is accompanied by increased peristalsis and suppression of the growth of proteolytic microflora.
The rapid adsorption of short-chain fatty acids in the distal parts of the colon improves the absorption of water, sodium and other electrolytes.
As a result, lactulose has a laxative effect and normalizes the work of the intestine, stimulating the growth and reproduction of normal intestinal microflora (bifidogenic factor).
Excretion from the body - with intestinal contents, only 3% of the drug is excreted by the kidneys.
Simethicone - a product with defoaming properties. When ingestion in the digestive tract is not absorbed and eliminated from the body in an unchanged form. Reducing the surface tension at the interface, complicates formation and contributes to the destruction of gas bubbles in the contents of the gastrointestinal tract. The gases released in this way can be absorbed by the walls of the intestine or removed from the body. Reduces the feeling of discomfort in the abdominal region, sometimes accompanying the action of lactulose.