Carboxym® (Carboxim)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspsolution for intramuscular injection
Composition:

For 1 ml.

Active substance:

Carboxym® (in terms of anhydrous and free from residual organic solvents) - 150.0 mg.

Excipients:

citric acid - 31.5 mg, sodium hydroxide - 4.0 mg, sodium chloride - 0.26 mg, disodium edetate dihydrate (Trilon B) 0.1 mg, water for injection up to 1 ml.

Description:Transparent liquid from light yellow to yellow.
Pharmacotherapeutic group:Cholinesterase reactivator
ATX: & nbsp
  • Antidotes
    • Pharmacodynamics:

    Carboxyme belongs to the group of cholinesterase reactivators of the pyridinium series. It has a pronounced antidote effect in the treatment of lesions with organophosphorus compounds (OPC). Timely application of carboxyme significantly accelerates the recovery of cholinesterase activity, inhibited by FOS. Also has a positive effect on some other manifestations of poisoning (reduces bronchospasm, motor disorders, etc.). Carboxyme has low toxicity, almost no cholinolytic action.

    Indications:
    • The appearance of initial signs of poisoning the WCF (agitation, miosis, drooling, etc.) in the provision of medical care, starting with the health center.
    • Detection in persons under observation after being in the focus of infection, a decrease in the activity of cholinesterase.

    Carboxyme is used against the background of antidote (atropine, Athens, P-10M) and other means used in the treatment of FOS poisoning. After the introduction of a therapeutic antidote, carboxymethate is administered after 1 to 2 hours.

    Contraindications:

    If there are symptoms of intoxication, OPC contraindications for the use of carboxymethacid.

    Dosing and Administration:

    Intramuscularly, 1 ml. The total dose of carboxymethylate used in the provision of care depends on the severity of the lesion.

    For lesions of WCF of mild degree (anxiety, miosis, drooling, sweating) after administration of preparations of holinolitic type of action, carboxyme is used in one therapeutic dose. In some cases, repeated administration of the drug in the same dose is possible.

    For lesions of FOS of moderate severity (exacerbation, myofibrillation, bronchospasm, cyanosis, tachycardia, less often bradycardia), as a rule, two applications of carboxime in one treatment dose with an interval of 2-3 hours will be required.

    For lesions of WCF of severe degree (convulsions, coma, respiratory and cardiovascular insufficiency), the dose of carboxyme can be increased to 3-4 ml. This dose is given by 1 ml of the drug at intervals of 1-2 hours.Treatment of affected OPC with the use of carboxyme in all cases is carried out with a systematic control of cholinesterase activity.
    Side effects:

    In the recommended dose, carboxymethylsulfate does not cause side effects. Nevertheless, with the use of large doses of carboxymus, there may be a deterioration in well-being, muscle weakness, dizziness, headache, nausea, tachycardia. Perhaps the emergence of transient paresthesias (mainly in the face area). On the ECG, there may be phenomena of intracardiac conduction disturbance and an increase in the systolic index. These phenomena soon pass and do not require additional treatment.

    Form release / dosage:Solution for intramuscular injection 150 mg / ml.
    Packaging:

    In ampoules of 1 ml. 1 ampoule together with instructions for use in a pack of cardboard.

    5 ampoules per contour cell packaging made of polyvinylchloride film without foil.

    2 contour squares with instructions for use in a pack of cardboard.
    Storage conditions:

    In a dry, dark place at a temperature of no higher than 20 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:For hospitals
    Registration number:P N001161 / 02
    Date of registration:06.06.2008 / 18.08.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:FARMZASCHITA NPC, FSUE FARMZASCHITA NPC, FSUE Russia
    Manufacturer: & nbsp
    Information update date: & nbsp08.12.2017
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