Combootec-2 (Combutec-2)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspsponge
Composition:

1 g of the preparation contains:

Active substance: collagen, substance-solution 2% - 48.64 g (0.9728 grams of dry collagen).

Excipients: glutarald (glutaraldehyde) 0.012 g, boric acid 0.015 g, oxyquinoline (quinazole) 0.0002 g.

Description:Plates cream or gray-cream color of the porous structure with a specific smell of acetic acid, with a relief surface, thickness from 4 to 8 mm, may have minor irregularities along the edges.
Pharmacotherapeutic group:Dermatoprotective agent
ATX: & nbsp
  • Nitrofuran derivatives
    • Pharmacodynamics:Collagen accelerates the healing of wounds, causing directional migration and grouping of fibroblasts, enhancing their activity. Positively affects fibrillogenesis by interacting with fibronectin, which is involved in binding cells to collagen fibrils. Collagen fibers act as a structural basis in the process of tissue formation. Collagen strengthens the repair process, accelerates and regulates the growth and maturation of granulation tissue; reducing the risk of formation of hypertrophic scars, stimulates epithelization. Collagen promotes accumulation in the wound of leukocytes and purification of the wound from bacteria and products of necrosis. Creates a moisture barrier, preventing drying of the wound.Protects the wound from external influences and infection. In the wound, collagen undergoes gradual biodegradation - lysis and resorption.
    Indications:

    - Treatment of chemical, radiation and thermal burns of II and III A degrees;

    - protection of wound and burn surfaces from external influences and prevention of secondary infection in all phases of the wound process;

    - temporary closure of burns III B degree (after removal of the scab);

    - treatment of shallow posttraumatic wounds in the phases of granulation and epithelialization;

    - trophic ulcers, bedsores, flaccid wounds;

    - preparation of wounds for autodermoplasty.

    Contraindications:Hypersensitivity, abundant wound exudation, skin necrosis, infected wounds (more than 100,000 microbial bodies per 1 g of tissue).
    Pregnancy and lactation:No contraindications found.
    Dosing and Administration:

    The wound must first be treated with an antiseptic solution and the necrotic tissues removed. The sponge is removed from the package immediately before use, following the rules of asepsis. The number and size of the sponge is selected, according to the area and depth of the wound. If necessary, the sponge is cut into pieces of the correct size and shape.The sponge should fit snugly to the entire surface of the wound and extend beyond its edges by 0.5 cm. If necessary, cover the sponge with a bandage or two layers of gauze. The frequency of dressings depends on the depth and area of ​​the wound surface, the intensity of exudation and the presence of necrotic masses.

    The condition of the wound is monitored once a day with a small amount of detachable and 2 times a day with abundant. A sponge completely impregnated with exudate is removed and replaced with a new one. If the sponge is dry in the wound, it is recommended to dress 1 time in 2-3 days, during this period the sponge is lysed. If the sponge did not resolve, and there is no indication for the dressing (pain, burning sensation in the wound, accumulation of purulent exudate, the presence of allergic reactions), it is not removed.

    With third degree burns, the first dressing is carried out after 6-8 hours.

    The course of treatment is carried out until complete epithelialization, or filling the wound with granulation tissue to the full depth. Autodermoplasty is performed in areas where juicy pink granulations are formed under the sponge. At the donor site, the sponge is left until self-rejection after complete epithelialization of the wound.

    Side effects:

    Allergic reactions in the form of itching, hyperemia, short-term burning in the wound area.

    Pain in the area of ​​the wound (due to its contraction with the drying of the sponge).

    Overdose:Cases of overdose are not described.
    Interaction:The drug is compatible with external applications of antibacterial, antiseptic and anesthetic drugs.
    Special instructions:

    When copious purulent discharge of medication recommended combined with antiseptic solutions, e.g., gidroksimetilhinoksalindioksida (dioxidine) or nitrofural (furatsilin), wetting of the sponge.

    To eliminate pain from tightening the wound with a sponge, it is necessary, without removing the sponge, to moisten it with a 0.25% solution of procaine, or with an aqueous 0.02% solution of nitrofural.

    Form release / dosage:Sponge size (240 ± 15) x (140 ± 10) mm and (140 ± 10) x (120 ± 10) mm, (90 ± 10) x (90 ± 10) mm, (50 ± 5) x (50 ± 5) mm.
    Packaging:

    1 piece packed tightly into bilayer foil bags with polyethylene or in a container from a film polyvinylchloride and aluminum foil with a heat sealable coating or a film: Polymer, "Polyform" "Plastiplen" and laminated paper, or only of film: Polymer, "Polyform "," Plastiplen ".

    A two-layer bag of polyethylene film or a container together with an instruction for use is placed in a cardboard pack.

    Storage conditions:

    In a dry, dark place at a temperature of 10 to 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    4 years.

    Do not use at the end of the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N003375 / 01
    Date of registration:30.06.2009
    Expiration Date:Unlimited
    The owner of the registration certificate:BELKOZIN - LUZHSKY FACTORY, OJSC BELKOZIN - LUZHSKY FACTORY, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp01.02.2018
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