Mafusol - instructions for use, dose, side effects, contraindications

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Dosage form: & nbspsolution for infusions

Composition:

In 1 liter of the solution contains: sodium fumarate-14 g, sodium chloride - 6 g, potassium chloride - 0.3 g, magnesium chloride hexahydrate (in terms of anhydrous substance) - 0.12 g.

Ionic composition: sodium ion - 280 mmol, chloride ion 109 mmol, fumarate ion 86 mmol, potassium ion 4 mmol, magnesium ion 1.2 mmol.

Description:A clear, colorless liquid.

Pharmacotherapeutic group:Rehydrating agent

ATX: & nbsp

Electrolytes

Pharmacodynamics:

Saline infusion solution, the main pharmacologically active component of which is sodium fumarate-antihypoxant, activates the adaptation of the cell to a lack of oxygen. Its effect is due to participation in the reactions of reversible oxidation and reduction in the Krebs cycle. In the course of these reactions, ATP synthesis occurs in an amount sufficient to maintain the functions of the body cells during hypoxia.

At metabolic acidosis shows alkalizing effect, its osmolarity is 400-410 mOsm / l, with hypovolemic conditions quickly replenishes the volume of circulating blood, prevents dehydration of tissues.

Reduces the viscosity of blood and improves its rheological properties, increases diuresis, promotes the activation of detoxification processes; reduces the concentration in the blood of intermediate and final products of lipid peroxidation (antioxidant properties).

Indications:

Hypovolemic and hypoxic states of different etiology (blood loss, shock, trauma, intoxication).

Acute disorders of cerebral circulation in adults, flowing through ischemic and hemorrhagic type.

As a component of the perfusion mixture for filling the contour of the apparatus of artificial circulation in cardiosurgical operations in adults and children.

Contraindications:Hypersensitivity, craniocerebral injury, accompanied by increased intracranial pressure, as well as a condition in which intravenous injection of large volumes of fluid is contraindicated (including arterial hypertension and chronic heart failure).

Dosing and Administration:

Intravenous, struino and drip, less often - intraarterially.

Doses and the speed of administration are chosen in accordance with the indications and the condition of the patient.

With shock (hemorrhagic, burn, traumatic, operating) of mild and moderate severity adults are given a dose of 2-3 liters, initially jet, and with the normalization of hemodynamic indicators - drip; in children - in a dose of 20-25 ml / kg.

In severe shock in adults it is recommended to use in combination with erythrocyte-containing media, as well as colloid blood substitutes for hemodynamic action. The dose in this case is set individually, but not less than 1 liter; Children are injected at least 15 ml / kg.

In severe intoxication in adults (peritonitis, sepsis, intestinal obstruction, etc.) is administered up to 2-3 l / day in combination with other detoxification drugs; Children - 30-35 ml / kg / day.

As a hemodiluent when refilling the device of artificial circulation can be up to 50-70% of the perfusion solution introduced into the device.

In cases of blood loss, not exceeding 15% of the volume of circulating blood in adults and children, can be used as the only infusion medium.

Can be used in place of other polycomponent saline infusion solutions; in contrast to acetate and lactate-containing salt infusion media, it is also possible to appoint patients with extremely severe hypovolemia and hypoxia with phenomena of pronounced metabolic acidosis.

Side effects:When used at recommended doses does not cause side effects.

Overdose:

Too fast administration with the use of large doses can lead to the development of acute left ventricular failure.

Interaction:

It can be used in combination with colloidal solutions (preparations of dextran, Neogemodez, Hemodez, Gelatinol, etc.); it is also compatible with donor blood, erythromass, plasma and other blood preparations.

Do not interfere with the appointment of commonly used anti-shock drugs, including. drugs for neuroleptanalgesia (fentanyl, droperidol), benzodiazepines (diazepam , etc.), as well as muscle relaxants (suxamethonium, etc.), inhibitors of proteolysis (aprotipin) and alpha-adrenostimulants (dopamine, epinephrine).

Form release / dosage:

Solution for infusion.

Packaging:

For 400 ml in a glass bottle for blood, transfusion and infusion preparations, corked with rubber stopper and crimped with an aluminum cap.

Each bottle, together with instructions for use, is placed in a pack of cardboard.

12 or 15 bottles of 400 ml with the instructions for use for the number of bottles are placed in a group box - boxes of cardboard (with gaskets and lattices for bottles).

Storage conditions:

In a place inaccessible to children, at a temperature of 0 to 25 ° C.

Freezing the drug is not a contraindication to its use.

Shelf life:

2 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-009901/08

Date of registration:11.12.2008 / 26.04.2012

Expiration Date:Unlimited

The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia

Manufacturer: & nbsp

BIOSINTEZ, PAO Russia

Representation: & nbspBIOSINTEZ JSC BIOSINTEZ JSC Russia

Information update date: & nbsp26.03.2018

Illustrated instructions

Instructions

Mafusol (Mafusol)