Included in the formulation
АТХ:S.01.A.D Antiviral drugs
Pharmacodynamics:The preparation is a biosynthetic polyribonucleotide complex of polyriboadenyl and polyribouridyl acids. Inductor synthesis of endogenous interferon and other cytokines. Stimulates the formation of mainly alpha-interferon, to a lesser extent - beta and gamma-interferon. It induces the synthesis of interferon in peripheral blood leukocytes, as well as in tissues and organs containing lymphoid elements. A high level of interferon is maintained by daily administrations throughout the course. Has direct antiviral action against influenza viruses and other ARVI. Modulates the cytokine response when the cells are infected with a virus.
Pharmacokinetics:Not described.
Indications:- Flu
- Other respiratory viral diseases
- Viral diseases of the eyes.
Powder for the preparation of solution for subconjunctival administration: keratoiridocyclitis (keratouveitis), adenoviral and herpetic conjunctivitis, keratitis, stromal keratitis, iridocyclitis, chorioretinitis, optic neuritis (viral etiology).
Powder for the preparation of eye drops: adenoviral and herpetic conjunctivitis, superficial keratoconjunctivitis, keratitis.
X.J00-J06.J06 Acute upper respiratory tract infections of multiple and unspecified sites
X.J00-J06.J06.9 Acute upper respiratory tract infection, unspecified
X.J10-J18.J10 Influenza caused by an identified influenza virus
X.J10-J18.J11 Influenza, virus not identified
Contraindications:Hypersensitivity. For the introduction into the anterior chamber of the eye: keratoyridocyclitis with ulceration of the anterior surface of the cornea, conjunctivitis, in the presence of pathogenic microflora in conjunctival planting, infection of the teeth and paranasal sinuses.
Pregnancy and lactation:No data.
Dosing and Administration:Locally. To treat influenza and other acute viral respiratory infections (1 ml contains 50 U) drops 5 times a day for 5 days in the acute period of the disease, begin treatment no later than 1-2 days after the onset of symptoms.
Subconjunctival. Dissolve the contents of the vial in 1 ml of water for injection or 1 ml of 0.5% solution of novocaine and inject 0.5 ml of a conjunctiva daily or every other day. The course of treatment is 5-20 injections.
In endothelial forms of herpetic keratoididocyclitis, under operating conditions: 0.3-0.6 ml of the drug diluted in 1 ml of water for injection is slowly injected into the anterior chamber of the eye with a tuberculin syringe 2 times a week. The course of treatment is 3-5 injections.
Side effects:Allergic reactions. Subconjunctival administration causes a slight swelling of the lower eyelid and an increase in conjunctival injection of the vessels of the eye. When inserted into the anterior chamber of the eye, a brief increase in intraocular pressure may occur, the appearance of hemorrhages in the anterior chamber of the eye.
Interaction:Compatible with antibiotics, enzyme preparations reduce the effectiveness of the drug in connection with the destructive action of enzymes on endogenous interferon.
Special instructions:Adverse events are transient and disappear after discontinuation of the drug after 1-3 days.
Impact on the ability to drive vehicles and manage mechanisms not found.