| Antibacterial preparation | Dosing regimen |
| A group of penicillins (a combination of a broad-spectrum penicillin with an inhibitor βlactamases) |
| Amoxicillin + clavulanoacid (amoxicillin + clavulanic acid) AmoxiclavTM, AugmentinTM | For mild or moderate infections, the dose for oral administration for children is 20 mg / kg / day, calculated as amoxicillin, divided into 3 receptions. For children over 14 years of age, the single dose is 300-500 mg per amoxicillin. In severe infections, the dose for oral administration for children is 40 mg / kg / day per amoxicillin, divided into 3 receptions. For children over 14 years of age, a single dose is 500-1000 mg per amoxicillin. In / in a single dose of 30 mg / kg premature infants is administered 2 times a day, newborns and children up to 3 months 3 times a day, children older than 3 months - 3-4 times a day. To prevent postoperative complications prior to surgery, during introductory anesthesia I / O inject 1.0 g of amoxicillin. In the postoperative period, the drug can be administered up to 4 times a day. The course of therapy 5-14 days |
| Ticarcillin + clavulanic acid (ticarcillin + clavulanic acid) TimentinTM | In / in a single dose of 80 mg / kg for ticarcillin, the rate of administration for premature infants and perinatal period - 2 times a day for children older than 1 month - 3-4 times a day. The maximum single dose for children older than 14 years and a body weight of more than 50 kg is 3.2 g with 4-fold administration |
| Piperacillin + tazobactam (piperacillin + tazobactam) TazocinTM | In / in (struyno slowly or drip) for children older than 12 years, the average daily dose is 12 g of piperazillin and 1.5 g of tazobactam, taken in 3-4 doses |
| Group of tetracyclines |
| Doxycycline (doxycyclin) Vibra-mycinTM | For children weighing less than 50 kg at the age of 8 years and over, the daily dose on the first day of admission is 4 mg / kg once inside, then the same daily dose is taken in 2 divided doses for another 6-14 days. Children with a body weight of more than 50 kg and over the age of 12 years, the dose for the first intake is 200 mg once inside, then for another 6-14 days - 100 mg twice a day. Maximum doses for adults for oral administration of 600 mg per day, for IV administration 300 mg |
| Tetracycline (tetracycline) TetracyclineTM | For children older than 8 years - at 6.25-12.5 mg / kg every 6 hours or 12.5-25 mg / kg every 12 hours. The course of treatment - 5-7 days. Adults and children weighing more than 50 kg 250 each-500 mg orally every 6 hours for 7 days |
| Group of quinolones-fluoroquinolones |
| Fluoroquinolones of the second generation |
| Lomefloxacin (lomefloxacin) XenacvinTM, LomacinTM, LomefloxTM | Up to 15 years old is contraindicated. Children older than 15 years inside 400- (600-800) mg once a day for 3-21 days. The dose and duration of treatment depend on the severity of the disease and the sensitivity of the pathogen. In acute gonorrhea - 600 mg once; with chronic gonorrhea - 600 mg / day for 5 days (against a background of specific immunotherapy). In urogenital chlamydia (including bacterial and chlamydial and gonorrhea-chlamydial infection) - 400-600 mg / day, the duration of treatment to 14 days; Mycoplasma infection - 600 mg / day, treatment course up to 10 days |
| Norfloxacin (norfloxacin) | Up to 15 years old is contraindicated. Children older than 15 years inside 400 mg twice a day for 1 hour before or 2 hours after eating 7-14-21 days. With uncomplicated gonorrhea - once in a dose 8001200 mg, with chronic or complicated gonorrhea - 400 mg twice a day for 3-5 days |
| Ofloxacin (ofloxacin) | Up to 15 years old is contraindicated. Children older than 15 years and adults inside for 30-60 minutes before meals or after meals with a small amount of water for 200-400 mg 2 times a day or 400-800 mg once a day for 7-10 days In case of severe infections, intravenous infusion (within 1 hour) 200 mg in 5% of r-dextrose (glucoseTM) 1 time per day. With a rapid on / in the introduction of a possible lowering blood pressure. With uncomplicated gonorrhea - once 400 mg, with chronic or complicated - 400 mg 2 times a day for 3-5 days. If the liver function is not more than 400 mg per day, if the renal function is impaired the first dose is not more than 200 mg, then not more than 100 mg every 24 hours, depending on the creatinine clearance |
| Pefloxacin (pefloxacin) AbaktalTM, peloks-400TM | Up to 15 years old is contraindicated. Children older than 15 years inside, while eating, drinking a lot of water, 400 mg 1-2 times a day for 14-21 days. If necessary, the dose can be increased to 1600 mg per day. In / in cases of severe infections - 800 mg, then 400 mg 2 times a day. The duration of the course is 1-2 weeks (no more than 4 weeks). In renal and hepatic insufficiency, a single dose (up to 8 mg / kg) and the frequency of administration (in proportion to the degree of damage to the function) should be reduced, |
| Ciprofloxacin (ciprofloxacin) AquaziproTM | Up to 15 years old is contraindicated. Children older than 15 years inside before eating, without chewing and drinking with a sufficient amount of liquid for 100-250 mg 2-3 times / day, with severe and complicated infections up to 750 mg 2-3 times / day. In / in the drip 200 mg (with severe infections 400 mg) 2 times a day. To prevent infection after surgery, inside 500-750 mg or iv in 200-400 mg. In acute gonorrhea - once inside 250-500 mg or iv in 100 mg. With chlamydia infection, the interior of 750 mg 2 times a day. Patients with severe renal dysfunction have a diurnal dose that is halved. If severe diarrhea develops, pseudomembranous colitis should be excluded (in which case ciprofloxacin contraindicated). Simultaneous IV administration of barbiturates requires control of cardiovascular function (blood pressure, ECG parameters) |
| Fluoroquinolones III generation |
| Sparfloxacin (sparfloxacin) RespiratoryTM | Up to 15 years old is contraindicated. Children over 15 years of age receive 400 mg once a day, irrespective of food intake, then 200 mg once a day. The duration of the course depends on the severity of the disease and the results of the bacteriological examination, usually 10 days. Against the background of a violation of liver function, dose adjustment is not required. With renal failure (clearance kreisatinin less than 50 ml / min) are prescribed 400 mg on the first day, then 200 mg once every two days, duration course is usually 9 days |
| Group of macrolides |
| Erythromycin (erythromycin) EomycinTM | Up to 3 months 20-40 mg / kg body weight per day, over 3 months at 30-50 mg / kg body weight per day (not more than 2.0 g per day) inwards, in 4 divided doses for 1.5-2 hours before meals or 2-3 hours after meals for 10-14 days. B / in the form of a constant or intermittent infusion is administered in a daily dose of 15-20 mg / kg / day, divided into 4 divided doses. In severe cases, it is possible to use a higher dose of the drug - 4 g / day |
| Azithromycin (azithromycin) AzivokTM, AzithralTM, AzitroxTM, AzitrocinTM | In children weighing less than 50 kg in doses at the rate of 10 (20) mg / kg orally once in the first day 1 hour before meals or 2 hours after meals,then 4 days - 5 mg / kg or 10 mg / kg per day for 3 days (course dose - 30 mg / kg), children with a body weight of more than 50 kg 1.0 g 1 time on the first day of therapy, and then 0.5 r1 razv day for 4 more days. With uncomplicated chlamydia, a single dose is possible, with the dose for children weighing less than 50 kg 10 mg / kg once, for children with a body weight of more than 50 kg - 1.0 g once |
| Josamycin (josamycin) WilprafenTM | The daily dose is 30-50 mg / kg of body weight, divided into 3 doses. Tablets are taken orally, between meals, without chewing, with a small amount of water. For young children, it is preferable to use a suspension of 3 months-1 year (body weight 5.5-10 kg), the dose is 7.5-15 ml / day, 1-6 years (body weight 10-21 kg) - 15-30 ml / day, 6-14 years - 30-45 ml / day. Children over the age of 14 are appointed by 1-2 grams per day in 2-3 hours. The course of therapy is 7-14 days |
| Clarithromycin (clarithromycin) BinoclarTM | The daily dose for children from 6 months to 12 years is 7.5 mg / kg body weight (maximum daily dose 0.5 g), divided into 2 divided doses. For children over 12 years, 250 mg orally 2 times a day. In severe infections, 500 mg every 12 hours; the maximum daily dose is 2 g. Tablets are taken orally, between meals, without chewing, with a small amount of water.The course of therapy is 7-14 days. In patients with renal insufficiency (with a creatinine clearance less than 30 ml / min or a serum creatinine concentration of more than 3.3 mg / 100 ml), single administration of 250 mg per day is recommended, in severe infections - 250 mg twice a day |
| Midekamycin (midecamycin) MacropenTM | Children under 12 years of age are prescribed 20-40 mg / kg of body weight per day in 2 divided doses or 50 mg / kg of body weight in 2 divided doses, with severe infections 50 mg / kg of body weight 3 times a day. It is preferable for children to prescribe the drug as a suspension (in 100 ml of water), a single dose of a suspension for children weighing up to 5 kg is 3.75 ml, for children with a weight of 5-10 kg, 7.5 ml, 10-15 kg - 10 ml, 15-20 kg - 15 ml, 20-30 kg - 22.5 ml. The drug is taken orally before meals. Children over 12 years of 400 mg 3 times a day, the maximum daily dose - 1600 mg. Duration of therapy 7-10 days, with treatment of chlamydial infection - 14 days |
| Oleandomycin (oleandomycin) Oleandomycin phosphateTM | For children under 3 years, the daily dose is 20 mg / kg, from 3 to 6 years - 250-500 mg, from 6 to 14 years - 500-1000 mg, divided into 4-6 receptions. For children older than 14 years, 250 mg 4-6 times a day. The drug is taken orally after a meal. The course of treatment - 5-7 days |
| Roxithromycin (roxithromycin) | For children, the daily dose is 5-8 mg / kg body weight, divided into 2 doses.For children older than 12 years, 150 mg twice a day or 300 mg once a day. The drug is taken orally, 15 minutes before a meal, with a sufficient amount of water, for 7-12 days. In severe renal and hepatic insufficiency, the daily dose is reduced by 2 times |
| Spiramycin (spiramycin) RovamycinTM | For children with a body weight of more than 40 kg appoint at the rate of 150-300 thousand IU per kg of body per day, divided into 2-3 oral administration. For children older than 15 years, 6-9 million IU (6-9 g) per day in 2-3 oral or intravenous drip. The course of therapy 10 days |
| Group of lincosamides |
| Clindamycin (clindamycin) | Inside for children 8-25 mg / kg body weight per day in 3-4 hours. For children with a body weight of more than 50 kg, 150-450 mg 3-4 times a day. In cases of severe infections, IM or IV infusion for infants, 15-20 mg / kg / day, for children older than 1 month - 15-40 mg / kg / day in 3-4 hours, for children with a body weight of more than 50 kg - 0,6-2,7 g / day in 3-4 doses of IM (the maximum single dose of 600 mg, the maximum daily dose of 4.8 g) |
| Lincomycin (lincomycin) LincomycinTM, Lincomycin hydrochlorideTM | Children aged 1 month to 14 years inside - in a daily dose of 30 mg / kg of body weight, with severe infections - up to 60 mg / kg. In / in the drip - 10-20 mg / kg every 8-12 hours. Children over 14 years of 500 mg 3-4 times a day. In severe infection, an I / m dose is prescribed, 600 mg 1-2 times a day.In / in the drip - 600 mg in 250 ml of isotonic sodium chloride solution or dextrose (glucoseTM) 2-3 times a day (duration of infusion at least 1 hour). The maximum daily dose is 8 g. Inside an hour before meals or 2 hours after a meal |
| Group of cephalosporins |
| Third generation cephalosporins |
| Cefixim (cefixim) SupraxTM, ceftanTM | For children from the age of 6 months to 12 years, appoint a dose of 8 mg / kg once or in 2 divided doses (4 mg / kg every 12 hours). It is preferable for children to prescribe the drug as a suspension, with a daily dose of suspension for children aged 6 months to 1 year 2.5-4 ml, at the age of 2-4 years - 5 ml, at the age of 5-11 years - 6- 10 ml. For children over 12 years of age weighing more than 50 kg, the average daily dose is 400 mg (once a day or 200 mg twice a day). With uncomplicated gonorrhea - 400 mg once |
| Cefoperazone (cefoperazon) DardumTM | Children under 3 months are appointed only for life reasons. With the / m introduction for children under 12 years 25100 mg / kg 2 times a day. For children over 12 years - usually 1-2 g 2 times a day. With IV introduction (the drug is administered slowly, in the form of a solution with a concentration of 100 mg / ml) for children under 12 years, the maximum single dose is 50 mg / kg, over 12 years - 2 g, with a severe infection, a single dose can be increased to 4 g. With uncomplicated gonorrhea: once, in / m 0.5 g. Prevention of postoperative complications: intravenously, 1-2 g for 30-90 min before the operation, then every 12 h, but usually not more than 24 h |
| Cefotaxim (cefotaxim) DuataksTM | For premature and newborn infants up to 1 week, 50-100 mg / kg in 2 divided doses, 1-4 weeks - 75-150 mg / kg in 3 divided doses, with a body weight of up to 50 kg - 50-100 mg / kg (for heavy infections - up to 200 mg / kg) in 3-4 sessions. Children with a body weight of more than 50 kg per 1 g (in severe infections - 2 g) 2-3 times a day. The maximum daily dose is 12 g. Parenterally, in / in or / m. In acute gonorrhea - 0.5-1 g once per month. For the prevention of postoperative infectious complications: before or during an initial anesthesia - 1 g, if necessary, again after 6-12 h |
| Ceftazidime (ceftazidim) BiotumTM | Children in 2 divided doses, up to 2 months of age - 25-50 mg / kg / day, older than 2 months - 50-100 mg / kg / day. Children older than 12 years, 1 g every 8 hours or 2 g at 12 h / m or IV. In severe cases - 6 g. Against the background of kidney dysfunction (depending on the severity of the lesion) - 1 g in 12 or 24 hours, or 0.5 g every 24-48 h |
| Ceftibuten (ceftibuten) TzedekTM | Inside, regardless of food intake. Children (up to 10 years and weighing less than 45 kg) - 9 mg / kg per day (maximum 400 mg per day) in the form of a suspension. Children over 10 years of 400 mg once a day.Duration of treatment - 5-10 days, with infections caused by Streptococcus pyogenes, - not less than 10 days |
| Ceftriaxon AzaranTM, BiotraksonTM, IphietsefTM, LendacinTM, LifaxonTM, MegionTM | In / m or in / in newborns up to 2 weeks 20-50 mg / kg / day, children from 2 weeks to 12 years - 20-80 mg / kg / day, children over 12 years of age and body weight of at least 50 kg - on 1-2 g once a day, the maximum daily dose is 4.0 g, divided into 2 doses. For the treatment of gonorrhea with a body weight of less than 45 kg, 0.125 g and at a weight of 45 kg or more, 0.25 g IM once. For the prevention of postoperative infections - 1 g once for 1 / 2-2 h before surgery |
| Cephalosporins of the fourth generation |
| Cefepim (cefepim) MaksipimTM | Parenteral: in / in and / m. Adults and children under 13 years of age - 0.5-1 g (with severe infections up to 2 g). In / in (slowly, for 3-5 minutes) or deep in / m at intervals of 12 hours (with severe infections - after 8 hours). The course of treatment is 7-10 days or more |
| Group of aminoglycosides |
| Gentamicin (gentamicin) | Parenteral: in / in and / m. Young children with severe infections only for life: up to 1 year - in a dose of 2-5 mg / kg / day, 1-5 years - 1.5-3 mg / kg / day, 6-14 years - 3 mg / kg / day. The daily dose is divided into 2-4 injections. The maximum daily dose is 5 mg / kg. The course of therapy 7-10 days |
| Spectinomycin (spectinomycin) KirinTM, TrobitsinTM | With uncomplicated gonorrhea (endocervical, rectal and urethral forms) - with a body weight of less than 45 kg - 40 mg / kg of mass and at a weight of 45 kg or more - 2.0 grams of IM once. In the generalized form of gonorrhea - in / m with a body weight of less than 45 kg - 40 mg / kg of mass and at a mass of 45 kg and more - 2.0 g 2 times a day for 3 days |
| Group of carbapenems |
| Meropenem (meropenem) MeronemTM | For children from 3 months to 12 years and weighing less than 50 kg, a single dose is 10-20 mg / kg every 8 hours. For children over 12 years, 500 mg 3 times a day |
| Ertapenem (ertapenem) InwanceTM | Parenteral by 1.0 g once a day |
| Imipenem + cilastatin (imipenem) TienamTM | Parenteral in / m and / in. Children older than 3 months with a body weight of less than 40 kg prescribed at a dose of 15 mg / kg every 6 hours. At a weight of 40 kg or more, depending on the severity of the infection, the daily dose is 1-4 g / day, divided by 3-4 infusions. For the prevention of postoperative infection, the drug is administered IV with anesthesia and 1.0 g an hour later, if necessary, repeat the administration of the drug at 8 and 16 h after surgery |
| Group of nitroimidazoles |
| Metronidazole (metronidazol) AquametroTM | Inside during or after a meal. Children under 12 years - 7.5 mg / kg 3 times a day, children over 12 years - 400-500 mg 3 times a day for 7-10 days |
| In severe cases, the drug is administered parenterally (intravenously) in the same dosages in 100 ml of the solvent. Infusion is carried out at a rate of 5 ml / min at intervals of 8 hours. Trichomoniasis. For children 2-5 years - 250 mg / day, 5-10 years - 250-375 mg / day, 10-12 years - 500 mg / day inside, with the daily dose divided into 3 divided doses. For children over 12 years - 400 mg 2 times a day. The course of therapy is 5-8 days (if necessary, repeated course in 4-6 weeks) or once 2.0 g or 250 mg twice a day for 10 days. Intravaginally at night for 10 days for 1 candle. To prevent the development of postoperative anaerobic infection: 1 day after the operation - 1 g of the drug once, then 200 mg 3 times a day for 7 days |