Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):ONLS
АТХ:D.10.A.D. Preparations for the treatment of acne for external use containing retinoids
D.10.A.D.53 Adapalene in combination with other drugs
Pharmacodynamics:Benzoyl peroxide as a source of active form of oxygen quickly penetrates into the pores of the skin, strengthens metabolic processes and has a bactericidal action (Propionibacterium acnes). Effective for correction of non-inflammatory acne, namely open and closed comedones, thanks to keratolytic and comedological actions.
Adapalene has a retinoid-like action, like vitamin A, by interacting with intranuclear keratocyte receptors, activates transcription factors, enhancing the regenerative abilities of the skin. Has a photosensitizing effect.
The combination of the keratolytic and keratoplastic component provides a positive effect in the treatment of comedones. Benzoyl peroxide is the conductor of adapalene in the lower layers of the epidermis and in the sacs of the hair follicles, as a result of which the effectiveness of the combined preparation increases several fold, compared with the use of drugs alone.
Pharmacokinetics:Benzoyl peroxide does not penetrate the subcutaneous tissue further, the effect of the drug on the basal membrane of the dermis is limited to its surface.
Adapalene is also not absorbed into the total bloodstream and does not have systemic effects on the body.
Indications:Used for the treatment of acne eruptions, including with discharge acne. Positive effect is observed after 1-2 weeks. The course of treatment is up to 6 weeks. In the treatment of actinic dermatosis - up to 9 months.
XII.L60-L75.L70 Acne
XII.L60-L75.L71 Rosacea
Contraindications:Individual intolerance.
Carefully:When breastfeeding is not recommended to apply the gel on the mammary glands, so that the drug does not hit the baby in the mouth.
Pregnancy and lactation:Pregnancy and lactation: recommendations for FDA - C. Data on the penetration of the drug into breast milk is not available.
Dosing and Administration:Apply a thin layer once a day before going to bed on a dry, clean skin.
Use in children over 12 years: 1-2 times a day.
The highest single dose: 0.5 -1.0 mg / kg.
The highest daily dose: 2.0 mg / kg.
Side effects:Allergic reactions.
Dry skin, peeling, burning, itching.With prolonged insolation, it is possible to get burns and the development of photodermatitis due to the photosensitizing action of adapalene.
Emerging side effects progress for a week, then spontaneously disappear.
Overdose:With local use, almost no cases of overdose. In case of accidental ingestion, the stomach is washed.
Interaction:The use of the gel has no connection with food intake.
When prescribing other local antibacterial drugs, antagonism of benzoyl peroxide with clindamycin, erythromycin, and threthionin should be taken into account. It is recommended to use these drugs in the morning, maintaining an interval of 12 hours.
Special instructions:It is not recommended to apply the gel on the hair, getting the drug on clothes, due to the discolouring effect of benzoyl peroxide.