Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):ONLS
АТХ:D.10.A.X.30 Other drugs for topical treatment of acne in various combinations
Pharmacodynamics:The combination is adaptable and the antibiotic clindamycin provides a dual action: anti-inflammatory and antibacterial.
Adapalene has a retinoid-like action, like vitamin A, by interacting with intranuclear keratocyte receptors, activates transcription factors, enhancing the regenerative abilities of the skin. Has a photosensitizing effect.
Clindamycin belongs to the group of antibiotics of the group of lincosamines, which have a wide spectrum of action. Inhibits protein synthesis in prokaryotic ribosomes. It is active against Gram-positive pathogenic and opportunistic microflora, including Staphylococcus epidermidis, Streptococcus spp., Mycoplasma spp., As well as anaerobic microflora, including clostridia.
Pharmacokinetics:The drug is not absorbed deeper than the subcutaneous tissue and does not have a systemic effect on the body.
Indications:The drug is used in a similar way to the adaptal.Effective with draining acne, rosacea, papulopustular eruptions. Positive effect occurs after one to two weeks, the course of treatment is 2-4 weeks.
Contraindications:Individual intolerance.
Burns.
Carefully:Dermatitis, eczema.
Pregnancy and lactation:Pregnancy and lactation - the category of action on the fetus by FDA - FROM.
Dosing and Administration:It is applied externally before going to bed to clean, dry skin. The repeated course of treatment is carried out not earlier than in two weeks. From the thickness of the applied layer, the efficiency does not improve.
The highest single dose: 0.5-1.0 mg / kg.
The highest daily dose: 2.0 mg / kg.
Side effects:Allergic reactions.
Skin irritation.
Local hyperemia, scaling of the skin.
Overdose:There were no cases of overdose with external application.
Interaction:After applying the drug is not recommended to use cosmetic (especially alcohol-containing) funds.
Fully compatible with benzoyl peroxide.
Incompatible with solutions containing vitamins of group B, with aminoglycosides, penicillins, erythromycin, magnesium sulfate and calcium gluconate.
Special instructions:At the beginning of treatment may be an increase in acne.
When skin irritation is recommended, temporary discontinuation or complete withdrawal of the drug.
When applying the drug should avoid open wounds (eczema, dermatitis), as well as mucous membranes (eyes, nasal passages, lips).
The drug should not be used before sunbathing, including a solarium.