At the initial stages of treatment, there may be an aggravation of acne, which disappears during the treatment. If the skin irritates, stop using the gel (temporarily or completely).
Avoid contact with the eyes, oral cavity, nasal cavity and other mucous membranes. If the product is accidentally ingested in the eyes, mouth or nose should be rinsed immediately with warm water.
Excessive exposure to sunlight or ultraviolet radiation should be avoided. In case of prolonged exposure to the sun, do not apply the gel the day before, as well as on the day of the solar exposure and the subsequent day.
It is not recommended simultaneous use of cosmetics with drying or irritating effect (for example, cologne, perfume and other ethanol-containing products).
With external application of clindamycin, the occurrence of diarrhea and colitis is extremely rare, nevertheless, caution should be exercised, and with the development of severe or prolonged diarrhea, the drug should be discontinued and, if necessary, appropriate diagnostic and therapeutic measures taken. Pseudomembranous colitis can appear both on the background of long-term use, and 2-3 weeks after cessation of treatment; manifested diarrhea, leukocytosis, fever, pain in the abdomen (sometimes accompanied by secretions with bloody masses of blood and mucus). If these phenomena occur in mild cases, it is sufficient to cancel the treatment and apply ion-exchange resins (colestramine, colestipol), in severe cases, compensation for loss of fluid, electrolytes and protein, the appointment of vancomycin inwards or metronidazole is indicated. Do not use drugs that inhibit intestinal motility.