Active substanceTetramethyltetraazabicyclooctanedioneTetramethyltetraazabicyclooctanedione
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  • Adaptol
    pills inwards 
    Olainfarm, AO     Latvia
  • Dosage form: & nbsppills
    Composition:

    Composition per one tablet:

    active substance - tetramethyltetraazabicyclooctanedione 500.0 mg; Excipients - methylcellulose 3.3 mg; calcium stearate 1.7 mg.

    Description:Round flat-cylindrical tablets of white or almost white color with a facet and a risk.
    Pharmacotherapeutic group:Anxiolytic agent (tranquilizer).
    ATX: & nbsp

    N.05.B.X   Other anxiolytics

    Pharmacodynamics:

    The active substance of Adaptol tetramethyltetraazabicyclo-octanedione by chemical structure is close to the natural metabolites of the body - its molecule consists of two methylated fragments of urea that make up the bicyclic structure.

    Adaptol acts on the activity of the structures entering the limbic-reticular complex, in particular, on the emotionogenic zones of the hypothalamus, and also affects all the four major neurotransmitter systems - GABA, choline, serotonin and adrenergic, promoting their balance and integration, but not exerting peripheral adrenoblocking action. Eliminates or reduces anxiety, anxiety, fear, internal emotional tension and irritability.Soothing effect is not accompanied by muscle relaxation and violation of coordination of movements. It does not reduce mental and motor activity, therefore, Adaptol can be used during working day or school. Does not create an upbeat mood, a sense of euphoria. Sleeping effect does not have, but enhances the effect of hypnotics and normalizes sleep during its violations. Adaptol facilitates or removes nicotine abstinence.

    In addition to the soothing effect has nootropic effect. Adaptol improves cognitive functions, attention and mental performance, without stimulating the symptoms of productive psychopathological disorders - nonsense, pathological emotional activity.

    Pharmacokinetics:

    The drug is well (77-80%) absorbed from the gastrointestinal tract, up to 40% of the dose is associated with erythrocytes. The remaining part does not bind to blood plasma proteins and is in the blood plasma in a free form, so the active substance is unrestrictedly distributed throughout the body and freely overcomes the cell membranes. The maximum concentration of the active substance in the blood is reached after 0.5 h after the administration of the drug and the high level persists for 3-4 hours, then gradually decreases.55-70% of the accepted dose is excreted from the body with urine, the rest - with feces in unchanged form during the day.

    Tetramethyltetraazabicyclooctanedione is not metabolized and does not accumulate in the body.
    Indications:

    Neuroses and neurosis-like conditions (irritability, emotional instability, anxiety, fear).

    Improve the tolerability of neuroleptics and tranquilizers to eliminate the associated somatovegetative and neurological side effects.

    Cardialgia of various genesis (not associated with coronary heart disease). Nicotinic abstinence (as part of complex therapy to reduce the craving for tobacco smoking).

    Contraindications:

    Hypersensitivity to the components of the drug.

    Pregnancy and lactation.

    It is not recommended for children under 18 years.

    Dosing and Administration:

    Inside, regardless of food intake, 500 mg 2-3 times a day. The maximum single dose is 3 g, the daily - 10 g. The duration of the course of treatment is from several days to 2-3 months.

    In complex therapy as a means of reducing the craving for tobacco smoking - 500-1000 mg 3 times a day for 5-6 weeks.

    Side effects:

    Rarely - dizziness, lowering of arterial pressure, dyspeptic disorders, allergic reactions (skin rashes, itching), after taking high doses: bronchospasm, lowering of body temperature, weakness. With a decrease in blood pressure and / or body temperature (body temperature may drop by 1-1.5 ° C), the drug should not be stopped. Arterial pressure and body temperature are normalized independently. When allergic reactions occur, the drug should be discontinued.

    Overdose:

    The toxicity of the drug is very low. A typical clinical picture of an overdose is missing. Serious poisoning is not registered. Can be observed symptoms: weakness, hypotension, dizziness.

    Treatment. If you suspect an overdose, treat symptomatically, including gastric lavage.

    Interaction:

    Adaptol can be combined with neuroleptics, tranquilizers (benzodiazepines), hypnotics, antidepressants and psychostimulants.

    Special instructions:

    Addiction, dependence (mental and physical) and withdrawal symptoms to Adaptol have not been established.

    Effect on the ability to drive transp. cf. and fur:The drug can cause a drop in blood pressure and weakness, which can adversely affect the ability to drive and maintain machinery. Care must be taken.
    Form release / dosage:

    Tablets of 500 mg.

    Packaging:

    10 tablets per contour cell packaging made of polyvinylchloride film and aluminum foil.

    2 contour squares, together with instructions for use, are placed in a pack of cardboard.

    Storage conditions:

    In a dry place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    4 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-001756
    Date of registration:07.07.2011
    Expiration Date:Unlimited
    The owner of the registration certificate:Olainfarm, AOOlainfarm, AO Latvia
    Manufacturer: & nbsp
    Representation: & nbspOLAINFARM JSC OLAINFARM JSC Latvia
    Information update date: & nbsp23.01.2017
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