Acryderm - instructions for use, doses, side effects, contraindications

Excipients: methyl parahydroxybenzoate 0.2 g, paraffin solid 9 g, petrolatum 3 g; propylene glycol 5 g; paraffin liquid 18 g; wax emulsion 7 g; disodium edetate 0.1 g; sodium sulfite 0.05 g; water purified to 100 g.

Description:

The cream is white or almost white.

Pharmacotherapeutic group:Glucocorticosteroid for topical application

ATX: & nbsp

H.02.A.B.01 Betamethasone

Pharmacodynamics:

Acriderm® is a glucocorticosteroid for external use. Has anti-inflammatory, antiallergic, antiexudative, vasoconstrictive, antipruritic and antiproliferative action. It inhibits the accumulation of leukocytes, the release of lysosomal enzymes and pro-inflammatory mediators in the focus of inflammation, inhibits phagocytosis, reduces vascular-tissue permeability, prevents the formation of inflammatory edema.

When applied to the skin surface, the drug has a quick and powerful effect in the inflammation focus, reducing the severity of objective symptoms (erythema, edema, lichenification) and subjective sensations (itching, irritation, pain).

Pharmacokinetics:

When the drug is applied in therapeutic doses, the transdermal absorption of the active substance into the blood is very low. The use of occlusive dressings, inflammation and skin diseases increases the transdermal absorption of betamethasone, which can lead to an increased risk of systemic side effects.

Indications:

Diseases of the skin, amenable to glucocorticosteroid therapy:

- atopic dermatitis;

- allergic contact dermatitis;

- eczema (various forms);

- contact dermatitis (including professional) and other non-allergic dermatitis (including sun and radiation dermatitis);

- reactions to insect bites;

- psoriasis;

- bullous dermatoses;

- discoid lupus erythematosus;

- red flat lichen;

- exudative erythema multiforme;

- itching of various etiologies.

Contraindications:

- Hypersensitivity to betamethasone or other components of the drug.

- bacterial (skin tuberculosis, cutaneous manifestations of syphilis), fungal, viral (varicella, herpes simplex) skin diseases, skin post-vaccination reactions, open wounds, trophic ulcers of the shin, rosacea, acne vulgaris, skin cancer, nevus, atheroma, melanoma, hemangioma , xanthoma, sarcoma;

- Lactation and children under 1 year.

Carefully:

With prolonged use or application on large surfaces: cataract, diabetes, glaucoma, tuberculosis.

Pregnancy and lactation:

The safety of external use of glucocorticosteroids in pregnant women is not established;The prescription of drugs of this group during pregnancy is justified only if the potential benefit to the mother exceeds the possible risk to the fetus. During pregnancy, drugs of this group Do not use in high doses or for a long time.

If it is necessary to use the drug during lactation it is recommended to stop breastfeeding.

Dosing and Administration:

Outwardly. Acriderm® cream is applied a thin layer on the affected area of the skin 2 times a day - in the morning and in the evening, gently rubbing. On areas with denser skin (for example, elbows, palms and feet), as well as places from which the drug is easily erased, Acriderm® cream can be applied more often.

The duration of treatment depends on the effectiveness and tolerability of therapy and is usually not more than 4 weeks. During the year, repeated therapy is possible.

Acriderm® cream is used to treat the inflammatory phase of the disease, including wetting skin lesions.

In children and patients with skin lesions, treatment should not exceed 5 days.

If clinical improvement does not occur, it is necessary to clarify the diagnosis.

Side effects:

As a rule, they have a weak character.

With external application of glucocorticosteroids, skin itching, burning, irritation, dry skin, folliculitis, hypertrichosis, striae, acne-like eruptions ("steroid" acne), hypopigmentation, perioral dermatitis, allergic contact dermatitis can be observed.

With prolonged use, as well as the use of occlusive dressings - skin maceration, secondary infection, skin atrophy, local hirsutism, telangiectasia, sweating, purpura.

When applied to extensive body surfaces, mainly in children, there may be systemic side effects of glucocorticosteroids (hyperglycemia, glucosuria, reversible oppression of adrenal cortex function, manifestation of Isenko-Cushing syndrome).

If there are any side effects not described in the instructions, you should consult your doctor.

Overdose:

Acute overdose is unlikely, however, with excessive or prolonged use of the drug, a chronic overdose is possible, accompanied by signs of hypercorticism: hyperglycemia, glucosuria, reversible suppression of adrenal cortex function, manifestation of Itenko-Cushing syndrome.

Treatment: it is recommended that the drug be phased out and, if necessary, symptomatic treatment.

Interaction:

Interactions of the drug with other drugs have not been identified.

Special instructions:

It is not recommended long-term external application of the drug on the face skin, since it is possible to develop rosacea, perioral dermatitis and acne. The course of treatment should not exceed 5 days.

Acriderm® cream is not intended for use in ophthalmology. Avoid contact with eyes. If the product gets on the mucous membranes of the eye, cataracts, glaucoma, fungal infections of the eye and the exacerbation of herpetic infection are possible.

With long-term treatment, when applying the drug on the vast surface of the skin, as well as in the armpits and inguinal folds, when using occlusive dressings, diapers, it is possible to systemically absorb glucocorticosteroids.

Children from 1 year of the drug is prescribed only for strict indications and under medical supervision, as it is possible to develop systemic side effects associated with betamethasone.

When using ointment in children from 1 year and older, the total duration of treatment should be limited and excludedactivities leading to increased resorption and absorption (warming, fixing and occlusive dressings, diapers).

When applying the drug on large surfaces and / or under the occlusive dressing, it is possible to suppress the function of the hypothalamic-pituitary-adrenal system and the development of symptoms of hypercorticism, a decrease in the excretion of growth hormone, an increase in intracranial pressure can be observed.

Effect on the ability to drive transp. cf. and fur:

Does not affect.

Form release / dosage:

Cream for external use, 0.05%.

Packaging:

For 15, 30 or 50 g in an aluminum tube.

Each tube together with instructions for use in a pack of cardboard.

Storage conditions:

At a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N000663 / 01

Date of registration:11.09.2012 / 12.08.2016

Expiration Date:Unlimited

The owner of the registration certificate:AKRIKHIN HFK, JSC AKRIKHIN HFK, JSC Russia

Manufacturer: & nbsp

AKRIKHIN HFK, JSC Russia

Representation: & nbspAKRIKHIN OJSC AKRIKHIN OJSC Russia

Information update date: & nbsp03.07.2017

Illustrated instructions

Instructions

Acriderm® (Akriderm®)