The incidence of side effects is classified according to the recommendations of the World Health Organization: very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely (including isolated cases) - less than 0.01%.
Infectious diseases: infrequently - nasopharyngitis.
On the part of the blood and lymphatic system: rarely - neutropenia, leukopenia, thrombocytopenia.
From the side of metabolism and nutrition: often - increased appetite, weight gain; infrequently - anorexia, hypoglycemia, hyperglycemia; rarely - weight loss.
From the nervous system: very often - dizziness, drowsiness; often - euphoria, confusion, decreased libido, irritability, insomnia, disorientation,ataxia, impaired attention, impaired coordination, memory impairment, tremor, paresthesia, imbalance, amnesia, sedation, lethargy; infrequent - depersonalization, anorgasmia, anxiety, depression, agitation, mood lability, increased insomnia, depressed mood, difficulty in word selection, hallucinations, nightmarish dreams, increased libido, panic attacks, apathy, cognitive disorders, hypoesthesia, nystagmus, speech impairment , myoclonic spasms, weakening of reflexes, dyskinesia, psychomotor agitation, postural dizziness, hyperesthesia, loss of taste sensations, burning sensation on the mucous membranes and skin, intentional tremor, stu op, fainting; rarely - disinhibition, elevated mood, hypokinesia, parosmia, dysgraphia.
From the side of the organ of vision: often - blurred vision, diplopia; infrequent - visual impairment, narrowing of visual fields, reduced visual acuity, eye pain, asthenopia, as well as dry eyes, puffiness of the eyes, increased lacrimation; rarely - flashing of "sparks" before the eyes, eye irritation, mydriasis,Oscilloscopy (subjective sensation of fluctuations in the subjects under consideration), impaired perception of the depth of vision, loss of peripheral vision, strabismus, increased brightness of visual perception.
From the side of the hearing organ and labyrinthine disorders: often - vertigo; rarely - overexercise.
From the cardiovascular system: infrequently - "hot flashes", skin hyperemia, lowering blood pressure (BP), increasing blood pressure, tachycardia, atrioventricular blockade of the I degree; rarely - sinus tachycardia, sinus bradycardia, sinus arrhythmia.
On the part of the respiratory system, the organs of the thorax and the mediastinum: infrequently - shortness of breath, dryness of the mucous membrane of the nasal cavity; rarely - nasal congestion, epistaxis, rhinitis, snoring, a feeling of "restraint" in the throat.
From the digestive system: often - dryness of the oral mucosa, bloating, vomiting, constipation, flatulence; infrequently - increased salivation, gastroesophageal reflux, hypoesthesia of the oral mucosa; rarely - ascites, dysphagia, pancreatitis.
From the skin and subcutaneous tissues: infrequently - papular rash, sweating; rarely - cold sweat, hives.
From the side of the kidneys and urinary tract: infrequently - dysuria, urinary incontinence; rarely - oliguria, renal insufficiency.
From the musculoskeletal system and connective tissue: infrequently - muscle twitching, joint swelling, stiffness of muscles, muscle spasms, myalgia, arthralgia, back pain, pain in the limbs; rarely - spasm of the neck muscles, pain in the neck, rhabdomyolysis.
From the side of the reproductive system: often - erectile dysfunction; infrequently - sexual dysfunction, ejaculation delay; rarely - amenorrhea, pain in the mammary glands, enlargement of mammary glands in the volume, dysmenorrhea, discharge from the mammary glands.
Other: often - fatigue, swelling, including peripheral, feeling of "intoxication", violation of gait; infrequently - asthenia, falls, thirst, a feeling of "restraint" in the chest, generalized edema, chills, pain; rare - hyperthermia.
Laboratory and instrumental data: infrequently - increased activity alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase; rarely - hypercreatininaemia, hypokalemia.
Side Effects in Post-Marketing Surveillance
The following adverse reactions were identified during the practical use of pregabalin.Since these messages were received from patients, it was not always possible to assess their frequency or to establish a causal relationship with taking pregabalin.
From the nervous system: frequency unknown - headache, loss of consciousness, cognitive impairment.
From the side of the organ of vision: frequency unknown - loss of vision.
From the digestive system: rarely - swelling of the tongue, nausea, diarrhea.
From the skin and subcutaneous tissues: rarely - edema of the face, itchy skin.
Allergic reactions: frequency unknown - hypersensitivity reaction, allergic reaction, angioedema, Stevens-Johnson syndrome.
From the side of the cardiovascular system: frequency unknown - chronic heart failure, QT interval elongation.
From the urinary system: frequency unknown - urinary retention.
From the respiratory system: frequency unknown - pulmonary edema.