Clinical and pharmacological group: & nbsp

Genotoninizing agents and adaptogens

Regenerants and reparants

Included in the formulation
  • Aloe liniment
    liniment externally 
    VIFITEH, CJSC     Russia
  • Aloe juice
    juice inwards 
    VIFITEH, CJSC     Russia
  • Aloe extract liquid
    solution PC 
    DALHIMFARM, OJSC     Russia
  • Aloe extract liquid
    solution PC 
    VIFITEH, CJSC     Russia
  • Aloe extract dry
    raw materials. inwards 
    Olimp, OOO     Russia
  • АТХ:

    S.01.B   Anti-inflammatory drugs

    Pharmacodynamics:

    Inactivation of bradykinin, inhibition of prostaglandin synthesis, inhibition of thromboxane, inhibition of tirokinase activity. Laxative: stimulation of colon activity, acceleration of transit, reduced absorption of water, increased paracellular permeability, probably due to inhibition of Na-, K-ATPase or inhibition of the chlorine channels, which increases the concentration of water in the intestinal contents.

    Pharmacological effects

    Laxative. Anti-viral. Hypoglycemic. Local anti-inflammatory and analgesic.

    Pharmacokinetics:

    Not studied.

    Indications:

    Inflammatory diseases of the digestive tract, accompanied by constipation and a decrease in secretory activity; acute diseases of the upper respiratory tract; dermatitis of various etiologies, infected wounds, trophic ulcers, burns, radiation damage to the skin; chronic inflammatory diseases of female genital organs, prostatitis (as part of complex therapy), progressive myopia, inflammatory diseases of the eyes (blepharitis,conjunctivitis, keratitis), opacity of the vitreous.

    VII.H00-H06.H01.0   Blepharitis

    VII.H10-H13.H10.4   Chronic conjunctivitis

    VII.H10-H13.H10.2   Other acute conjunctivitis

    VII.H15-H22.H16   Keratite

    VII.H43-H45.H43.3   Other opacities of the vitreous humor

    VII.H49-H52.H52.1   Myopia

    IX.I80-I89.I83.2   Varicose veins of the lower extremities with ulcer and inflammation

    X.J00-J06.J00   Acute nasopharyngitis (runny nose)

    X.J00-J06.J01   Acute Sinusitis

    X.J00-J06.J02   Acute pharyngitis

    X.J00-J06.J03   Acute tonsillitis

    X.J00-J06.J04   Acute laryngitis and tracheitis

    XI.K55-K63.K59.0   Constipation

    XII.L20-L30.L20.8   Other atopic dermatitis

    XII.L20-L30.L23.9   Allergic contact dermatitis, cause not specified

    XII.L20-L30.L21   Seborrheic dermatitis

    XII.L55-L59.L58   Radiation dermatitis radiation

    XIV.N40-N51.N41   Inflammatory diseases of the prostate

    XIV.N70-N77.N71   Inflammatory diseases of the uterus, except the cervix

    XIV.N70-N77.N72   Inflammatory disease of the cervix

    XIX.T20-T32.T30   Thermal and chemical burns, unspecified

    XIX.T79.T79.3   Post-traumatic wound infection, not elsewhere classified

    Contraindications:

    To systemic application: hypersensitivity to aloe, garlic, onion, tulip or other plants of the lily family (Liliaceae), children under 10 years; diseases of the kidneys, heart, intestinal obstruction, intestinal atony,chronic constipation; inflammatory bowel disease (granulomatous disease, nonspecific ulcerative colitis), irritable bowel syndrome, diverticulitis; appendicitis; pain of unknown origin in the abdomen; deep wounds, severe dehydration, electrolyte disorders, spasms, colic, hemorrhoids; pregnancy, breast-feeding.

    To topical application - hypersensitivity.

    Carefully:Be wary of applying sc.
    Pregnancy and lactation:

    Pregnancy

    The category of FDA recommendations is not defined. Adequate and well-controlled studies on humans and animals have not been conducted. Do not use: it probably causes an abortion.

    Lactation

    Metabolites of anthranides penetrate into the milk. Do not apply!

    Dosing and Administration:

    As part of complex therapy. Peptic ulcer of stomach and duodenum, gastritis, gastroduodenitis, enteritis, colitis, cholecystitis. Inside for 5-10 ml of juice 30 minutes before meals 2-3 times a day. An active bleeding ulcer - 1 l of juice per day.

    Decreased appetite. Inside 5-10 ml of juice 30 minutes before meals 2-3 times a day.

    Constipation - 0.05-0.2 g before bedtime in tablets inside. Dry juice concentrate, 50-300 mg / day.

    Neuralgia, headache. Bronchial asthma.Subcutaneously 1-1.5 ml for 10-15 days daily, then 1 time in 2 days.

    Tuberculosis. The initial dose of 0.2 ml subcutaneously with a gradual increase.

    Pneumonia.

    Blepharitis, conjunctivitis, keratitis, vitreous opacity, myopic chorioretinitis, iritis, retinitis pigmentosa, inflammatory processes of the eye vessels, atrophy of the optic nerve, progressive myopia. Trachoma. Cicatricial changes in tissues, trophic ulcers.

    Scleroderma.

    Infertility (including in men).

    Inside the liquid extract 5 ml 2-3 times a day for 20-30 minutes before meals. The course of treatment is 30-45 days.

    Radiation sickness. Hearing and smell reduction. Stomatitis, laryngitis, pharyngitis. Locally, to rinse the mouth 50% aqueous solution of aloe juice.

    Burns (including radiation treatment and prevention), purulent wounds, inflammatory skin diseases. Alternatively, apply a thin layer on the affected surface 2-3 times a day and cover with a gauze napkin.

    Skin irritations, wounds. Capsules 100-200 mg / day, extract 50-100 mg / day, the local leaf gel is applied to the skin.

    Psoriasis. Locally 0.5% extract (hydrophilic) 3 times a day for 5 days a week, maximum - 4 weeks6.

    Diabetes mellitus.1 tablespoon 2 times a day with glibenclamide (5 mg 2 times a day for 42 days) or without it 7, 124-250 mg.

    Kidney stones. Dry juice concentrate, up to 300 mg / day.

    HIV AIDS. Inside 800-1600 mg / day.Subcutaneously daily 1 ml (the maximum daily dose of 3-4 ml). The course of treatment 30-50 injections, repeat after 2-3 months. The course of treatment is 30-35 injections.

    Inside, adults 0.05 g (1 tablet) 3-4 times a day for 15-20 minutes before meals. The course of treatment - 1 month, if necessary, repeat after 3-6 months. Liquid extract - 5 ml 2-3 times a day for 20-30 minutes before meals. The course of treatment is 15-30 days. The onset of a laxative effect is not earlier than 6 hours, no later than 24 hours after ingestion.

    Use in children

    As a laxative. 10-18 years: 0,04-0,11 g (Curacao or Barbados Aloe) or 0,06-0,17 g (Cape Aloe) of dry juice, 10-30 mg of hydro-xanthraquinones per day or 0.1 g of night once a day.

    Subcutaneously daily: up to 5 years; 0.2-0.3 ml; 5-18 years - 0.5 ml each. The course of treatment 30-50 injections, repeat after 2-3 months.

    Side effects:

    Spasms of smooth muscles, reversible damage to the intestinal mucosa, hemorrhagic diarrhea.

    Reversible staining of saliva and urine in red; reversible pseudomelanosis of the intestine, resolved within 4-12 months. Nephrotoxicity, secondary aldosteronism, hepatotoxicity with long-term admission. Contact dermatitis, slow healing of deep wounds. Hypokalemia with frequent use, hypocalcemia, metabolic acidosis, malabsorption, weight loss, albuminuria and hematuria, weakness,orthostatic hypotension. Steatorea, enteropathy with loss of protein, osteomalacia. Uterine contractions leading to spontaneous abortion. Malignant neoplasms (tumor of the caecum), mutagenicity, genotoxicity.

    Overdose:

    Thirst, diarrhea, dehydration, hypokalemia, especially in children and the elderly. Treatment: potassium level control, sufficient fluid intake.

    Interaction:

    Cardiac glycosides, systemic steroids, thiazide, loop diuretics - potentiation of the effect with joint ingestion. Datura stramonium, L. - intensification of the effect with prolonged use. Licorice naked (Glyzirrhiza glabra) - should be avoided together: may cause hypokalemia.

    Special instructions:

    Common for all drugs from medicinal plant material. Freshly prepared aqueous infusions from whole medicinal plant material are preferred.

    Distinctive characteristics. Safety and efficacy in comparison with other anti-inflammatory agents have not been studied. Stabilized extract is prepared with hot water, contains 19-21% aloin. In chronic use, it can reduce the level of serum potassium.Aloe juice can be used topically, notching, squeezing fresh leaves and applying gel to the damaged areas.

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