Amyloride + Hydrochlorothiazide (Amiloridum + Hydrochlorothiazidum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Diuretics

Included in the formulation
АТХ:

C.03.E.A.01   Hydrochlorothiazide in combination with potassium-sparing drugs

Pharmacodynamics:

Has hypotensive and diuretic effect. Displays sodium and stores potassium in the blood plasma. Diuretic effect begins two hours after taking the drug. The maximum effect is noted after 4 hours and lasts for 6-12 hours. At the initial normal arterial pressure, there is no decrease.

Pharmacokinetics:

The highest concentration of the drug in the blood plasma is observed 3-4 hours after oral administration. The half-life is 6-9 hours.

Bioavailability of 60-80%, communication with blood plasma proteins - up to 70-75%. Metabolism in the liver, elimination in the urine (99%) - decreased in chronic renal failure and in the elderly.

Indications:

It is applied for treatment of arterial hypertension, with edematous syndromes of any etiology to save potassium in the appointment of loop diuretics.

ICD-10

IX.I10-I15.I15   Secondary Hypertension

IX.I10-I15.I10   Essential [primary] hypertension

Contraindications:

Individual intolerance.

Hyperkalemia (when the content of potassium ions in the blood plasma is 5.5 meq / l and more).

Decompensated diabetes mellitus, gout.

Carefully:

Use with caution in patients with CRF, if hyperkalaemia occurs, the drug should be discontinued.

Have patients with diabetes mellitus in the treatment with hydrochlorothiazide requires the correction of oral hypoglycemic drugs or insulin.

Pregnancy and lactation:

Pregnancy and lactation: recommendations on FDA - category C in the I trimester, category D in the II and III trimesters. It enters the breast milk, reduces lactation: it is recommended to stop breastfeeding during treatment.

Dosing and Administration:

It is used according to the scheme: 1 tablet (amiloride hydrochloride 5 mg and hydrochlorothiazide 50 mg) twice a day. Or two tablets in the morning.

The highest daily dose is four tablets.

The highest single dose is two tablets.

Side effects:

Allergic reactions.

Central nervous system: headache, fatigue.

Cardiovascular system: arrhythmia, orthostatic hypotension, angina pectoris.

Gastrointestinal tract: anorexia, anorexia, nausea, vomiting, diarrhea, flatulence, hiccough, thirst.

Skin: hyperemia, itching, hyperhidrosis.

Musculoskeletal system: cramps in the calf muscles, pain in the legs and joints.

Respiratory system - shortness of breath.

Sense organs: blurred vision, nasal congestion, taste distortion.

Overdose:

Hyperkalemia: arrhythmia, supraventricular tachycardia, sinoartrial block, ventricular fibrillation.

Treatment: withdrawal of the drug, intravenous injection of 10 ml of 20% calcium gluconate. Intravenous infusion of 500 ml of 20% glucose solution + 10 units of insulin. The introduction of sodium bicarbonate - when it decreases in the blood to 10 mmol / l or less. The use of loop diuretics for the prompt removal of potassium in the urine.

Interaction:

Potentiates the effect of ACE inhibitors, increasing the risk of hyperkalemia.

Alcohol, drugs, barbiturates - potentiation of orthostatic hypotension.

Oral hypoglycemic drugs, insulin - reduced effect. Treatment correction required diabetes mellitus.

Muscle relaxants - potentiation of action.

Lithium preparations - lithium excretion by kidneys decreases, which can lead to lithium toxicity.

Nonsteroidal anti-inflammatory drugs - lowers the effect.

Special instructions:

The drug is effective in the treatment arterial hypertension, is safe in therapeutic doses.

Does not lead to hypokalemia, is recommended for prolonged use.

When taking the drug reduces the risk of repeated formation of calculous stones in the kidneys.

The manifestations of side effects are associated with an increase in the dose or with the intake of other potassium-sparing drugs.

Instructions
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