The undesirable reactions observed in patients are listed below. The frequency of adverse reactions was classified as follows: very frequent (≥10%), frequent (from 1% to 10%), infrequent (from 0.1% to 1%), rare (from 0.01% to 0.1%), very rare (<0.01%) and unidentified frequencies .
From the cardiovascular system: often - lowering blood pressure, orthostatic arterial hypotension; infrequently bradycardia; rarely - ischemia of peripheral tissues; unknown frequency - subendocardial hemorrhage, thrombosis;
From the hemopoietic system and lymphatic system: infrequently - agranulocytosis, coagulation disorder; frequency unknown - leukopenia, thrombocytopenia;
From the immune system: infrequently - allergic and anaphylactic reactions; frequency unknown - maculopapular rashes;
With moans of the senses: often - nasal congestion; rarely - reduced visual acuity, lacrimation.
From the musculoskeletal system: infrequently - muscle weakness, myalgia; rarely - increased activity of CK, myositis; frequency unknown - acute myopathy, myoglobinuria, rhabdomyolysis;
From the central nervous system: often - dizziness, noise in the ears, headache; very rarely - confusion, convulsions, delirium, hallucinations, increased intracranial pressure, impaired cerebral circulation, fainting; From the gastrointestinal tract: often - abdominal pain, diarrhea, nausea, vomiting;
From the urinary system: frequency unknown - acute renal failure, increased blood urea nitrogen, renal colic, impaired renal function;
From the upper respiratory tract: infrequently - shortness of breath; rarely - pulmonary embolism; frequency unknown - inflammation of the upper respiratory tract;
Local reactions: infrequently - skin rash, itching;
On the part of the body as a whole: often - general weakness, pain and necrosis at the injection site; infrequently - swelling.