Ammifurin® (Ammifurin®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

For one tablet:

Active substance:

Ammi large fruit furokumariny (Ammifurin®)

(in terms of 100% and absolutely dry substance)

0.020 g

Excipients:

Milk sugar (lactose)

0.062 g

Potato starch

0.017 g

Calcium stearate

0.001 grams
Description:Tablets are round, biconvex, light yellow with a greenish shade with darker patches, with a weak specific odor.
Pharmacotherapeutic group:Photosensitizing agent of plant origin
ATX: & nbsp
  • Psoralens for systemic use
    • Pharmacodynamics:

    Ammifurin® is the sum of furocoumarins: isopimpinellin, bergapten and xanthatexin, isolated from ammonium large - Ammi majus L. families of celery - Apiaceae.

    Ammifurin® has a photosensitizing effect.

    Pharmacokinetics:The drug is a complex of biologically active substances (the amount of furocoumarins), and in this regard, the conduct of pharmacokinetic studies is not possible.
    Indications:

    Applied in adults with vitiligo, nest and total baldness, psoriasis.

    Contraindications:

    Intolerance to ultraviolet irradiation (UFO) and psoralens. Diseases,accompanied by increased sensitivity to light (albinism, systemic lupus erythematosus).

    In combination with UFD in the following diseases:

    - tuberculosis;

    - thyrotoxicosis;

    - decompensated endocrine diseases;

    - blood diseases;

    - liver disease (hepatitis, liver cirrhosis);

    - kidney disease (nephritis);

    - diseases of the cardiovascular system (chronic heart failure, hypertension II-III degree);

    - diseases of the central nervous system (cachexia);

    - acute gastritis, peptic ulcer of stomach and duodenum in the stage of exacerbation;

    - pancreatitis;

    - diabetes;

    - pregnancy and the period of breastfeeding;

    - cataract;

    - multiple pigment nevi;

    - benign and malignant tumors;

    - deficiency of lactase, lactose intolerance, glucose-galactose malabsorption;

    - age to 18 years.

    Dosing and Administration:

    The drug is prescribed in combination with ultraviolet irradiation (UFV).

    The drug (20 mg) is administered orally after meals, with milk, at a dose of 0.8 mg / kg, but not more than 80 mg (4 tablets) per reception, once, 2 hours before UFO. The course dose of the drug is 100-150 tablets (2-3 g). Repeated courses are conducted at intervals of 1-1.5 months.

    With psoriasis procedures are carried out 4 times a week. UV irradiation starts with 1/2 biodose, gradually increasing to 5-6 biodosomes, which corresponds (depending on the individual sensitivity of the patient to UV radiation) the duration of irradiation from 1-2 minutes to 10-15 minutes. Total amount of irradiation compositionleat 15-20 procedures.

    With vitiligo, nest and total baldness UFO is carried out 3 times a week (every other day) - 20-25 exposures. A total of 4-6 courses.
    Side effects:Taking the drug in combination with UFO can be accompanied by nausea, a feeling of heaviness in the stomach, dizziness, headache, palpitations, cardialgia. In this case, the drug should be discontinued.
    Overdose:

    When an overdose of sunlight and artificial UV radiation can occur acute dermatitis (erythema, edema, possible blisters). In this case, the application should be discontinued until the dermatitis phenomena are resolved.

    Treatment: symptomatic.
    Interaction:

    The drug enhances the effect of other photosensitizers (including photosensitizing food and cosmetics).

    This therapy can be carried out against the background of the generally accepted drug treatment, which includes the use of penicillin, lidase, vascular drugs, and external agents.
    Special instructions:

    - Treat the drug under the supervision of a doctor.

    - When taking the drug inside, you must be careful when in direct sunlight; During the day, you need to wear sunglasses.

    - Care should be taken when using products and cosmetics containing photosensitizing substances.

    - With common forms of the disease, taking the drug inside is combined with its external application. External Ammifurin® in the form of a 0.3% solution is applied to the lesion sites 1 hour before UFO.

    - To avoid UV exposure to the apparently healthy skin surrounding the lesion, when applied locally, it is lubricated at a distance of 1-2 cm from the boundaries of the lesion with zinc paste or a photoprotective cream. After the procedure, the zinc paste is removed with a cotton swab dipped in vegetable oil.

    - 1 tablet contains 0,079 g of carbohydrates, which corresponds to 0,01 XE (bread units).

    Effect on the ability to drive transp. cf. and fur:

    When using the drug, care should be taken when carrying out potentially dangerous activities requiring concentration of attention and speed of psychomotor reactions (transport management,work with moving mechanisms, the work of a dispatcher and / or an operator).

    Form release / dosage:Tablets, 20 mg.
    Packaging:

    For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

    3 or 5 contour cell packs No. 10, together with instructions for medical use, are placed in a pack of cardboard for consumer containers.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    5 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LS-002598
    Date of registration:26.10.2011
    Expiration Date:Unlimited
    The owner of the registration certificate:FARMTSENTR VILAR, ZAO FARMTSENTR VILAR, ZAO Russia
    Manufacturer: & nbsp
    Representation: & nbspFARMCENTER VILAR CJSC FARMCENTER VILAR CJSC Russia
    Information update date: & nbsp18.08.2017
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