Diphtheric anatoxin (Anatoxinum diphtericum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
Read on
Clinical and pharmacological group: & nbsp

Vaccines, serums, phages and toxoids

Included in the formulation
  • Anatoxin diphtheria purified adsorbed with a reduced content of antigens liquid (AD-M-anatoxin)
    suspension w / m PC 
    MICROGEN FGUP Scientific and Production Association     Russia
  • Anatoxin diphtheria purified adsorbed with a reduced content of antigens liquid (AD-M-anatoxin)
    suspension for injections 
    BIOMED them. I.I.Mechnikova, OJSC     Russia
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    ONLS

    АТХ:

    J.07.A.F   Vaccine for the prevention of diphtheria

    J.06.A.A.01   Diphtheria Antitoxin

    Pharmacodynamics:

    Detoxification of the toxin produced Corynebacterium diphtheriae.

    Formation of antibodies to diphtheria toxin.

    Pharmacokinetics:

    Not studied.

    Indications:

    It is used for the prevention of diphtheria according to the established schedule of vaccinations, as well as in the foci of infection.

    ICD-10

    XXI.Z20-Z29.Z23.6   The need for immunization against diphtheria alone

    I.A30-A49.A36   Diphtheria

    Contraindications:

    Individual intolerance.

    Carefully:

    When revaccination with caution is administered to individuals who have had side effects.

    Pregnancy and lactation:Recommendations for Food and Drug Administration (US Food and Drug Administration) - not determined. Vaccination of pregnant and lactating women is made only by epidemiological indications. It is recommended to stop lactation for 2 days after administering the drug.
    Dosing and Administration:

    It is injected intramuscularly or deeply subcutaneously into the subcutaneous region.

    The highest daily dose of 0.5 ml.

    The highest single dose is 0.5 ml.

    Side effects:

    Allergic reactions.

    Perhaps the development of hyperthermia, malaise in the first day after the administration of the drug.

    Overdose:

    Cases of overdose are not described. Treatment is symptomatic.

    Interaction:

    The timing of the vaccination is not dependent on food intake. Clinically significant interactions with other drugs have not been observed.

    Special instructions:

    The vaccination of persons who have had infectious diseases is carried out two weeks after the convalescence. In chronic diseases with stable manifestations, vaccination is performed against the background of treatment.

    According to epidemics, the vaccine is administered to people with acute illnesses. To prevent complications, prednisolone is used: inside 1.0-1.5 mg / kg per day before vaccination and immediately after injection.

    Each injection of the drug is recorded in a special registration form, which indicates the number of the series, the expiration date of the drug.

    The vaccine is used immediately - it is not stored in an open ampoule.

    Instructions
    Up