pharmachologic effect
Active active ingredient of the preparation Angioflux® - sulodexide - natural product, a natural mixture of glucosaminoglycans, consisting of a high-speed heparin-like fraction (80%) and dermatan sulfate (20%), obtained by enzymatic extraction from the mucous membrane of the small intestine of pigs. The mechanism of action of sulodexide is due to the interaction of both fractions:
- a high-speed heparin-like fraction has an affinity for antithrombin III (ATIII);
- dermatan sulfate has an affinity for the cofactor Heparin II (KG II).
Pharmacodynamics
Angioflux® has antithrombotic, profibrinolytic, angioprotective and anticoagulant effects.
The mechanism of antithrombotic action is associated with the suppression of activated Ha and Pa clotting factor, increased synthesis and secretion of prostacyclin, a decrease in the concentration of fibrinogen in the blood plasma.
The prophyllinolytic effect of the drug is due to an increase in the concentration of the tissue plasminogen activator (TAP) in the blood vessel and the decrease in the content of the inhibitor of tissue plasminogen activator (ITAP) in the blood. The mechanism of angioprotective action is associated with the restoration of the structural and functional integrity of the vascular endothelial cells, restoring the normal density of the negative electric charge of the pores of the basal membrane of the vessels. The drug normalizes the rheological properties of blood by reducing the concentration of triglycerides, as it stimulates the lipolytic enzyme - lipoprotein lipase, hydrolysing triglycerides. The efficacy of Angioflux® in diabetic nephropathy is determined by itsthe ability to reduce the thickness of the basal membrane and the production of the extracellular matrix by reducing the proliferation of mesangium cells.