Immunoglobulin is administered intramuscularly.
Prevention
The dose of the drug and the frequency of its administration depend on the indications for use:
- newborns from motherscarriers of HBsAg or patients with acute hepatitis B during the delivery period, 1 dose of the drug (100 IU) is administered in the first 12 hours after birth simultaneously with the hepatitis B vaccine, but in different parts of the body (hereinafter children are to be vaccinated with hepatitis B vaccine at the age of 1, 2 and 12 months);
- persons not previously vaccinated against hepatitis B, or to persons who have not completed vaccination, or when the level of HBs-antibodies is below protective (<10 IU / L), after accidental infection as a result of exposure to infected material (when injected , dental manipulation, blood transfusion, splashing of infected material into the mouth or eyes, etc.), the drug is administered at a rate of 0.1 ml / kg of mass as soon as possible after contact (if possible within 24-48 hours).
Simultaneously (on the same day), it is necessary to start (continue) vaccination against hepatitis B according to the scheme 0-1-2-12 months.
- persons belonging to high-risk groups infected with hepatitis B virus (patients with chronic hemodialysis centers, patients suffering from various diseases,which according to vital indications receive frequent transfusions of blood and its contact preparations in hepatitis B foci, etc.), not vaccinated against hepatitis B, immunoglobulin is administered before the procedure - hemodialysis, blood transfusion and its preparations, etc .; children under 10 years old - 100 ME, children over 10 years and adults - at the rate of 0.1 ml / kg of weight.
Simultaneously with the introduction of immunoglobulin, a course of vaccination against hepatitis B should be initiated according to the truncated scheme - 3 administration of the vaccine at intervals of 1 month. After 12 months after the start of immunization, 4 additional doses of the vaccine are administered. The first dose of the vaccine is administered simultaneously with the immunoglobulin, but in different parts of the body.
If it is necessary to use large volumes (more than 5 ml) of the drug, it is recommended to inject into different parts of the gluteus muscle and the external surface of the thigh.
The drug is used only as directed by a doctor (paramedic).
The introduction of immunoglobulin is recorded in the prescribed registration forms, indicating the serial number, date of issue, expiry date, manufacturer, date of administration, dose, response to administration.
Treatment
With a therapeutic purpose, the drug is prescribed in the first five days from the onset of icteric viralhepatitis B.
The drug is administered in a single dose of 0.1 ml / kg of body weight, daily for 3 days.