Antilimfolin dissolved in 250-450 ml of 0.9% solution of sodium chloride or 5% solution of dextrose and injected intravenously at a rate of 20-30 drops per minute. The solution is prepared ex tempore.
Before using the drug to determine the sensitivity of the recipient to plasma proteins of goats or rabbits, 0.1 ml of a 1% solution of the drug should be administered intravenously. To obtain 1% solution of the drug in an ampoule with 50 mg of protein, 5 ml of a 0.9% solution of sodium chloride is injected. In the absence of a local and general reaction, intravenous administration of a therapeutic dose of Antilympholin begins.
During the introduction of the drug, a biological sample must be performed: first 10-15 ml of the solution is injected, after which the drug should be discontinued for 15 minutes. In the absence during this period of clinical manifestations of allergic reactions (patient anxiety, redness of the face, pain in the muscles, bones, lower back, paresthesia, etc.), the drug is continued to drip.
The dose of the drug administered, as well as the frequency of its administration, are determined individually for each patient depending on the nature of the disease (organ transplantation or treatment of aplastic anemia), the sensitivity of the patient to the drug and the general condition of the patient (leukocyte count, leukocyte count, platelet count, immunoglobulin and other things).Before the administration of the drug, 250-500 mg of methylprednisolone is injected intravenously to prevent the reaction to a heterogeneous protein.
When transplanting organs and tissues to prevent a crisis of rejection the drug is administered daily at a dose of 10-15 mg / kg body weight of the patient for 10-14 days after transplantation. Depending on the condition of the transplanted organ (tissue) and the patient's condition, the administration of the drug can be continued in the same doses for another 5-7 days.
To suppress the beginning of rejection reaction the drug is prescribed daily at a dose of 15-25 mg / kg for 10-14 days. If necessary, the term of treatment can be extended to the 21st day.
For the treatment of aplastic anemia Antilimfolin is prescribed in a daily dose of 15-25 mg / kg body weight of the patient for 5 days. The drug is administered intravenously drip for 6-8 hours. Simultaneously, in order to prevent serum sickness for 1-5 days intravenously drip in a 0.9% solution of sodium chloride, inject methylprednisolone 2 mg / kg, followed by a transition to oral administration, a gradual dose reduction and a complete cancellation by day 14.
The dose of the drug is individualized according to the results of laboratory blood tests.After infusion of the drug after 1-5 hours, the number of lymphocytes decreases by 20-70% of the initial level.
The amount of the drug administered during the infusion is determined by the selected individual single dose (in mg / kg of body weight), the weight of the patient and the protein content in the ampoule (indicated on the label).