Antistax® (Antistax®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspcapsules
Composition:

Each capsule contains:

active ingredient grapes red leaves extract dry (4-6: 1) 180.00 mg

Excipients:

silicon dioxide colloidal 9.35 mg,

dextrose liquid [dextrose, oligo- and polysaccharides] 38.25 mg,

corn starch 8.40 mg,

magnesium stearate 2.60 mg,

talc 8.40 mg.

capsule shell:

gelatin 63.004 mg,

sodium lauryl sulfate 0.152 mg,

titanium dioxide (E171) 0.760 mg,

iron dye red oxide (E172) 0.912 mg,

ferric iron oxide yellow (E172) 0.152 mg,

purified water 11.020 mg

Description:

Hard gelatin capsules, brownish red, size 1.

Contents of capsules - brown or brown powder with a reddish-violet shade of color with a characteristic, slightly aromatic odor, it is allowed to clump and stick together the powder in the form of a column.

Pharmacotherapeutic group:Angioprotective agent of plant origin
ATX: & nbsp
  • Bioflavonoids
    • Pharmacodynamics:

    The extract of red leaves of grapes contains pharmacologically active flavonoids, the main of which are quercetin-glucuronide and isokvertsetin. The drug has a protective effect on the vascular endothelium (stabilizing the membranes and increasing the elasticity of blood vessels), normalizing vascular permeability. Reducing the permeability of the vascular wall to plasma, protein or water from the vessels to the surrounding tissue slows the formation of edema and reduces existing swelling.

    Indications:

    Prevention and symptomatic treatment of chronic venous insufficiency (in combination with varicose veins), including edema of the lower limbs, a feeling of heaviness and fatigue in the lower limbs, a feeling of tension, paresthesia (change in sensitivity), and pain.

    Contraindications:Hypersensitivity to the components of the drug, age to 18 years.
    Pregnancy and lactation:

    Antistax ® is not recommended for use during pregnancy and during breastfeeding. Studies on the safety of the drug in pregnant women and breast-feeding were not conducted.

    Dosing and Administration:

    The drug is taken orally 2 capsules 1 time a day before meals, in the morning. The dose may be increased to 4 capsules per day. Capsules should be swallowed whole, washed down with water. The course of treatment is 12 weeks. It is possible to apply a second course on the recommendation of a doctor.

    In order to prevent exacerbations, the drug is taken 2 capsules 1 time per day for 4 weeks. Prophylactically, the drug is recommended to be applied 2 times a year.

    Side effects:

    Reactions from the skin and subcutaneous tissues:

    Infrequently, generalized pruritic skin rash (less than 1%),

    Uncommon - hives (less than 1%).

    Allergic reactions:

    Infrequently, hypersensitivity reactions (less than 1%).

    Reactions from the gastrointestinal tract:

    Infrequent - discomfort in the epigastric region (dyspepsia, including nausea, pain in the epigastric region), constipation, diarrhea (less than 1%).

    Overdose:

    Single cases of drug overdose have been reported, but no specific symptoms requiring treatment have been identified. No serious adverse event associated with treatment with Antistaks®

    Interaction:

    Not known.

    Special instructions:

    In case of a sudden edema, redness of the skin, a feeling of tension, burning and pain, especially in one leg, it is necessary to immediately consult a doctor. These symptoms can be a consequence of the development of thrombophlebitis. After consultation with a doctor, you can resume the use of the drug. If there is persistent edema of both legs, a doctor's consultation is necessary, since it can be caused by other causes. In case of insufficient or unsatisfactory therapeutic effect during 6 weeks of treatment, you should consult a doctor.

    One capsule contains 8.8 mg of glucose (0.00074 XE).The maximum daily dose (4 capsules) contains 35.2 mg of glucose (0.00296 XE). The drug should not be taken by patients with glucose-galactose malabsorption.

    Effect on the ability to drive transp. cf. and fur:

    Studies on the effect of the drug on the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions have not been carried out. To date, there have been no cases of drug effects on the ability to drive vehicles, mechanisms.

    Form release / dosage:Capsules, 180 mg.
    Packaging:For 10 or 20 capsules in PVC / PVDC / aluminum blister. By 2,3, 5,10 or 16 blisters together with the instructions for use are placed in a cardboard box.
    Storage conditions:

    In a dry place, at a temperature of 15-25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N 015635/01
    Date of registration:23.03.2009 / 02.08.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:SANOFI RUSSIA, CJSCSANOFI RUSSIA, CJSC
    Manufacturer: & nbsp
    GINSANA, SA Switzerland
    Representation: & nbspSanofi Russia, JSCSanofi Russia, JSCRussia
    Information update date: & nbsp06.09.2017
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