Antitoxin venom vulgaris (Antitoxinum veneni Viperae)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Vaccines, serums, phages and toxoids

Included in the formulation
  • Serum against venom of viper ordinary horse cleaned concentrated liquid
    solution for injections 
    MICROGEN FGUP Scientific and Production Association     Russia
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    ONLS

    АТХ:

    J.06.A.A.03   Blood serum against snake venom

    Pharmacodynamics:

    The preparation contains a specific immunoglobulin protein fraction of whey of horses hyperimmunized with the viper of an ordinary viper.

    When parenterally administered, the antibody enters the human blood and neutralizes the snake venom of the viper.

    Pharmacokinetics:

    Not studied.

    Indications:

    It is used after the bites of an ordinary viper in humans and animals.

    ICD-10

    XIX.T51-T65.T63   Toxic effect due to contact with poisonous animals

    Contraindications:

    Individual intolerance to heterogeneous proteins is the development of anaphylactic shock.

    Carefully:

    Increased individual sensitivity to the drug.

    Pregnancy and lactation:Pregnancy and lactation: recommendations for Food and Drug Administration (US Food and Drug Administration) - not determined.The drug is used for emergency indications in pregnant women, nursing and children.
    Dosing and Administration:

    In order to prevent the development of an anaphylactic shock, 1-2 tablets of antihistamine (diphenhydramine, tavegil, etc.) are taken orally before injection. Subcutaneously, fractional for It is not rare: in any part of the body, regardless of the weight of the patient, one treatment dose is administered. Initially, 0.1 ml, then 0.25 ml (in the absence of an allergic reaction for 15 minutes), after the next 15 minutes, the contents of the entire ampoule.

    The total dose of whey depends on the degree of intoxication:

    - mild degree: intramuscular, 1-2 doses;

    - severe: 4-5 doses.

    With severe intoxication, the drug is injected intravenously in a physiological solution, heated to 37 degrees. In extreme conditions, intravenous injection of the drug with a syringe without dilution is permissible. Before the injection of the drug must be introduced prednisolone in a dose of 60-90 mg.

    The highest daily dose - depends on the severity of clinical manifestations.

    The highest single dose: 5 therapeutic doses (5 ampoules).

    Side effects:

    Development of serum sickness.

    Allergic reactions are anaphylactic shock.

    Treatment: a complex of anti-shock measures, including resuscitation.

    Overdose:

    Not checked.

    Interaction:

    Clinically significant interactions with other drugs have not been observed.

    Special instructions:

    After the introduction of the drug, the patient should be monitored for one hour.

    The administration of the antitoxin should be recorded in a special document specifying the dose, time of administration, patient response and labeling on the package (series, manufacturer).

    Instructions
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