Active substanceAntitoxin venom vulgarisAntitoxin venom vulgaris
Dosage form: & nbspinjection
Composition:

The preparation is an immunoglobulin fraction of blood serum of horses immunized with a viper venom, purified and concentrated by peptic digestion and salt fractionation, containing specific antibodies.

Composition (1 treatment dose):

Specific immunoglobulins neutralizing the venom of the viper are 15 ° AE.
Description:

It is a clear or slightly opalescent, colorless or yellowish liquid with no precipitate.

Pharmacotherapeutic group:MIBP is serum.
ATX: & nbsp

J.06.A.A.03   Blood serum against snake venom

Pharmacodynamics:

Biological properties. Antibodies contained in the serum neutralize the venom of the viper.

Indications:Treatment of people bitten by an adder.
Contraindications:Contraindication to the continued use of serum is only the development of anaphylactic shock with the introduction of 0.1-0.25 ml of serum.
Pregnancy and lactation:

When pregnancy is possible, use according to vital indications, taking into account the benefits to the mother and the possible risk to the fetus. The lactation period is not a contraindication to the use.

Dosing and Administration:

First aid to the bitten on the spot. The victim is laid in the shade and given a copious drink: tea, coffee, milk, broth, water (alcohol consumption is prohibited) and 1 therapeutic dose of whey is administered regardless of the body weight of the bitten. In order to avoid anaphylactic shock or other allergic complications, before entering the serum, 1-2 tablets of any antihistamine drug (diphenhydramine, pipolfen, tavegil, etc.) are given inside. Serum is injected subcutaneously fractional (according to Beside) to any part of the affected body: first 0.1 ml, in the absence of reaction after 10-15 minutes, 0.25 ml is injected and then through. 15 minutes in the absence of adverse reactions all remaining serum. The opened ampoule should be covered with a sterile bandage or cotton swab. After providing first aid, it is necessary to provide emergency hospitalization of the victim to the nearest medical institution, where the treatment will continue. Transport the patient in a lying position. The bitten leg is bandaged to a healthy one, giving a slightly elevated position. When bitten in the hand, it is fixed in a bent position with the help of tissue thrown over the neck.

Assistance in a medical institution. The total administered dose of serum is determined by the doctor depending on the degree of intoxication: at a mild degree intramuscularly 1-2 doses, with a heavy 4-5 doses, taking into account the dose administered before hospitalization. In case of particularly severe intoxication, serum is recommended to be injected slowly slowly after dilution (1/5 - 1/10) with a sterile, 0.9% solution of sodium chloride for injections heated to a temperature (37 ± 1) ° ะก. Rate of administration: first 1 ml for 5 min, then 1 ml per min. In exceptional cases, if it is not possible to perform drip infusion, a slow jet administration of a therapeutic dose of serum without dilution with a syringe is allowed. To avoid possible allergic reactions prior to the initiation of intravenous infusion of serum, 60-90 mg of prednisolone is injected strickenly. Intravenous introduction of serum is allowed only to medical personnel!

Children use the same dosing principle as adults, regardless of weight and age.

In some cases, when contaminating the site of the bite with earth, the presence of wounds, necrosis of any type of tissue, it is necessary to carry out measures for emergency prevention of tetanus in accordance with the instruction for the prevention of tetanus.

Precautions for application. Ampoules with serum before opening carefully examined. The drug is not applicable for:

- change in physical properties (turbid contents of the ampoule, the presence of non-breakable flakes);

- any damage to the integrity of the ampoules (cracks, etc.).

The drug for first aid, stored in conditions of expeditions with a violation of the temperature regime, is not suitable at the end of the expedition to the application.

Side effects:

The introduction of anti-venom serum can be accompanied by the development of various allergic reactions: immediate, coming immediately after the introduction or after a few hours and showing symptoms of anaphylactic shock, early - on the 2nd day after the introduction and distant - on the 5-10th day.The latter are accompanied by a symptomatic complex of serum sickness (fever, itching and rash on the skin, joint pain, etc.). When an anaphylactic reaction occurs, the introduction of serum is stopped. Subcutaneously inject epinephrine (epinephrine) (0.3-1 ml), cordiamine (1.5-2 ml), prednisolone 25 ml or hydrocortisone (50-100 ml), strophanthine (0.5 ml 0.04%) with glucose (20 ml 40 % solution). Given the possibility of shock when administered, the serum for each vaccinated should be provided for medical observation within 1 hour after the end of the drug administration.

Serum administration should be registered in established registration forms with obligatory indication of the date, method and time of administration, the patient's reaction, the manufacturer's enterprise and the serial number of the preparation.

Overdose:

Not installed.

Interaction:

It is necessary to take into account compatibility with other medicines containing in their composition a foreign protein.

Effect on the ability to drive transp. cf. and fur:None.
Form release / dosage:

Solution for injection 150 AE.

Packaging:In ampoules of 1 treatment dose (150 AE - not more than 3 ml).For 5 ampoules in a cardboard pack or 1 ampoule in a plastic box complete with a sterile single-use syringe for 5 ml and a needle. A scarifier or a volcanic separation disk and instructions for use are put in a pack or box.

Terms of leave. The drug, packed in plastic boxes of 1 ampoule (1 dose), complete with a syringe and needle, is dispensed without a prescription.

The drug, packed in 5 ampoules in cardboard packs (5 doses), is intended for use in medical and prophylactic institutions.
Storage conditions:

Conditions of transportation. In accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8 ° C.

Storage conditions. The drug is stored in accordance with the JV. 3.3.2.1248-03 out of the reach of children at a temperature of 2 to 8 0 FROM.

Shelf life:Shelf life 2 years. The drug with expired shelf life is not subject to application.
Terms of leave from pharmacies:Without recipe
Registration number:P N002482 / 01
Date of registration:04.06.2009
The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
Manufacturer: & nbsp
Information update date: & nbsp11.11.2013
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