Arthroker - instructions for use, dose, side effects, contraindications

lactose monohydrate 188,000 mg, povidone 5,000 mg, croscarmellose sodium 4,000 mg, sodium lauryl sulfate 1,000 mg, magnesium stearate 0.500 mg, silicon dioxide colloid 0.500 mg.

Hard gelatin capsule (body): gelatin 12,3959 mg, water 2,1750 mg, diamond brilliant blue 0.1035 mg, titanium dioxide 0.1463 mg, dye floxin B 0.0173 mg, methyl parahydroxybenzoate 0.1200 mg, propyl parahydroxybenzoate 0.0300 mg, sodium lauryl sulfate 0.0120 mg.

Hard gelatin capsule (lid): gelatin 20.0085 mg, water 3.4800 mg, brilliant blue colorant 0.0045 mg, titanium dioxide 0.2340 mg, dye quinoline yellow 0.0090 mg, dye floxin B 0.0048 mg, methyl parahydroxybenzoate 0.1920 mg, propyl parahydroxybenzoate 0.0480 mg, sodium lauryl sulfate 0.1920 mg.

Description:Hard gelatin capsules number "2", with the inscription "Micro / Micro" consisting of a gray body and a blue lid,the contents of the capsule are yellow granular powder.

Pharmacotherapeutic group:Non-steroidal anti-inflammatory drug.

ATX: & nbsp

M.01.A.X.21 Diacerein

Pharmacodynamics:Diacerein inhibits the synthesis and activity of interleukin-1 (IL-1), which plays an important role in the development of inflammation, degradation and subsequent destruction of cartilage in osteoarthritis. Diacerein also slows the formation of metalloproteinases (collagenase), which are involved in the process of damage to the cartilaginous tissue. With prolonged use diacerein stimulates the synthesis of proteoglycans and does not affect the synthesis of prostaglandins.

Pharmacokinetics:After oral administration diacerein It is rapidly absorbed from the gastrointestinal tract and completely deacetylated to rhein. Simultaneous intake of the drug with food increases bioavailability by 25%. The maximum concentration (C max) of rhein in plasma is reached after 144 minutes. The half-life of the plasma is 255 minutes. The connection of rhein with albumin is almost 100%. With a single admission, 50 mg of C max is 3.15 mg / l. With repeated administration of the drug, Cmax increases in connection with the cumulation of the drug.The Rhine is excreted by the kidneys unchanged (20%) and in the form of glucuronide (60%) and sulfate (20%). The Rhine penetrates the placental and blood-brain barrier.

Indications:Primary and secondary osteoarthritis.

Contraindications:Individual intolerance of the drug components or high sensitivity to anthraquinone drugs (eg, laxatives). Children's age (up to 18 years). Pregnancy, lactation. Severe hepatic or renal failure, intestinal obstruction, inflammatory bowel disease. Lactose intolerance, lactase deficiency, glucosogalactose malabrombosis.

Carefully:Patients with irritation of the lower intestinal tract drug is prescribed only in special cases.

Dosing and Administration:

Standard intake of 1 capsule 2 times a day (morning and evening, after meals). Capsules should be swallowed whole, not liquid, and washed down with water. The effect of treatment should be expected in 2-4 weeks. The arthroker is applied continuously for a long time or by courses lasting not less than 4 months. The length of the break between the courses of treatment is set by the doctor.

Precautions for use

Periodic monitoring of blood levels, activity of liver enzymes, urine is necessary. If the kidney function worsens, the doctor must decide whether to reduce the dose or to cancel it.

Side effects:

If hypersensitivity to the components of the drug may be allergic reactions of varying degrees, rash, itching. In the initial period of taking the drug, there can be temporary phenomena from the digestive system: diarrhea, nausea, vomiting, abdominal pain. In this case, the dose should be reduced to 1 capsule per day.

There can be intense urine coloration from yellow to brown (depending on pH), which does not require a reduction in the dose (withdrawal) of the drug.

Overdose:Overdose may cause diarrhea, weakness. In case of overdose or accidental medication, children should consult a doctor. Treatment is symptomatic.

Interaction:It is not recommended to take an arthroker together with drugs that affect the consistency of the contents of the intestine (for example, a large amount of cellulose). Antacids reduce the absorption of the drug.With simultaneous administration with antibiotics or chemotherapeutic drugs that affect the intestinal microflora, the frequency of adverse events from the intestine can increase.

Special instructions:The duration of treatment, depending on the result achieved, can be long. In the period preceding the development of the therapeutic effect, the arthroker can be taken simultaneously with non-narcotic analgesics and other non-steroidal anti-inflammatory drugs.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the driving of motor vehicles and employment by other potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Capsules 50 mg.

Packaging:

For 10 capsules in an aluminum strip or aluminum / aluminum blister.

1, 3, 6 or 10 strips / blisters in a pack of cardboard with instructions for medical use.

Storage conditions:In a dry, the dark place at a temperature of no higher than 30 ° C. Keep out of the reach of children.

Shelf life:

3 years. Do not use the drug after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-007748/09

Date of registration:02.10.2009 / 14.03.2016

Expiration Date:Unlimited

The owner of the registration certificate:KORAL-MED, CJSC KORAL-MED, CJSC Russia

Manufacturer: & nbsp

MICRO LABS, Limited India

Information update date: & nbsp14.09.2017

Illustrated instructions

Instructions

Артрокер (Artrocare)