Clinical and pharmacological group: & nbsp

Vitamins and vitamin-like remedies

Included in the formulation
  • Ascofol®
    pills inwards 
    ALTAYVITAMINS, CJSC     Russia
  • АТХ:

    B.03.B.B.51   Folic acid in combination with other drugs

    Pharmacodynamics:

    Ascorbic acid regulates the transport of hydrogen ions in oxidation-reduction reactions, including in the process at any stage of the Krebs cycle. Participates in the regulation of carbohydrate metabolism. Provides absorption of iron in the intestine, transferring it from trivalent into a divalent form, facilitating its incorporation into heme. Participates in the formation of tetrahydrofolic acid, the synthesis of steroid hormones, norepinephrine and adrenaline, collagen, prothrombin, glycogen. Inactivates hyaluronidase, activating the regeneration of tissues and normalizing the permeability of capillaries. Disinfects toxins and has an antioxidant effect, catching free radicals. He takes an active part in the regulation of immune processes: enhances the formation of antibodies, phagocytic activity and the synthesis of interferon. It inhibits the release of histamine and strengthens its degeneration, suppresses the release of mediators of inflammation and allergic reactions.

    Folic acid is activated in the liver in tetrahydrofolic acid,which is involved in the synthesis of pyrimidine and purine bases - components of nucleic acids (DNA, RNA). It takes part in the exchange of amino acids (glycine, methionine, etc.). Stimulates erythropoiesis, improves absorption of iron. During pregnancy participates in the formation of the nervous system of the fetus.

    Pharmacokinetics:

    Completely absorbed from the gastrointestinal tract after ingestion. It binds to plasma proteins in 25%. Normally, the concentration of ascorbic acid in the blood: 15-20 mcg / ml. The concentration of ascorbic acid in erythrocytes and plasma is lower than in platelets and leukocytes.

    Ascorbic acid is oxidized to dehydroascorbic acid, metabolized to inactive ascorbate-2-sulfate and oxalic acid, then excreted in the urine. In cases of exceeding the dose (more than 200 mg) ascorbic acid is eliminated by the kidneys in an unchanged form.

    Indications:

    It is used in conditions of deficiency of ascorbic and folic acid: sprue, macrocytic anemia.

    It is used in the complex treatment of anemia and leukopenia, including caused by ionizing radiation.

    The drug is necessary for the normal development of the fetal nervous system, especially in multiple pregnancies.

    III.D50-D53.D52   Folic deficiency anemia

    IV.E50-E64.E54   Insufficiency of ascorbic acid

    XV.O20-O29.O25   Malnutrition in pregnancy

    Contraindications:

    Individual intolerance.

    Carefully:

    Diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase, thalassemia, hyperoxalaturia, urolithiasis.

    Pregnancy and lactation:Recommendations for Food and Drug Administration (US Food and Drug Administration) - Category A. It is necessary for pregnancy and lactation, especially in the first trimester (the formation of the fetal neural tube).
    Dosing and Administration:

    Inside, 1-2 tablets after meals, 3 times a day, up to 30 days or more.

    In pregnancy and lactation - 1 tablet daily (preventive dose).

    The highest daily dose: up to 8 tablets a day.

    The highest single dose: 2 tablets.

    Side effects:

    Dyspeptic disorders are possible: nausea, irritation syndrome of the intestinal mucosa.

    Allergic reactions.

    Overdose:

    Headache, insomnia, increased excitability of the central nervous system, diarrhea, ulceration of the mucous membrane of the gastrointestinal tract.

    Treatment is symptomatic.

    Interaction:

    Ascorbic acid

    Fresh vegetable and fruit juices, alkaline drink - reduce the absorption of ascorbic acid in the gastrointestinal tract.

    With the simultaneous use of the drug with acetylsalicylic acid, the effectiveness of vitamin C is lost by one third due to a decrease in absorption in the gastrointestinal tract.

    The intake of ascorbic acid with iron preparations increases their effectiveness.

    Reduces the effectiveness of heparin and indirect anticoagulants.

    Reduces the effectiveness of neuroleptics - phenothiazine derivatives.

    Reduces the chronotropic effect of isoprenaline.

    Barbiturates accelerate the release of ascorbic acid in the urine.

    Tetracycline also increases the elimination of ascorbic acid.

    Folic acid

    Reduces the effectiveness of phenyotine.

    The use of antacids reduces the absorption of folic acid.

    Tiamterene, trimethoprim, methotrexate - reduce the effectiveness of folic acid.

    Oral contraceptives, anticonvulsants, analgesics - increase the need for folic acid.
    Special instructions:

    Patients on hemodialysis require an increase in the dose of the drug.

    At the time of taking the drug, antacids are allowed after 2 hours.

    With prolonged intake of the drug at maximum dosages, a decrease in the concentration of vitamin B12.

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