Ascorbic acid
Fresh vegetable and fruit juices, alkaline drink - reduce the absorption of ascorbic acid in the gastrointestinal tract.
With the simultaneous use of the drug with acetylsalicylic acid, the effectiveness of vitamin C is lost by one third due to a decrease in absorption in the gastrointestinal tract.
The intake of ascorbic acid with iron preparations increases their effectiveness.
Reduces the effectiveness of heparin and indirect anticoagulants.
Reduces the effectiveness of neuroleptics - phenothiazine derivatives.
Reduces the chronotropic effect of isoprenaline.
Barbiturates accelerate the release of ascorbic acid in the urine.
Tetracycline also increases the elimination of ascorbic acid.
Folic acid
Reduces the effectiveness of phenyotine.
The use of antacids reduces the absorption of folic acid.
Tiamterene, trimethoprim, methotrexate - reduce the effectiveness of folic acid.
Oral contraceptives, anticonvulsants, analgesics - increase the need for folic acid.