Included in the formulation
АТХ:A.11.G.B.01 Ascorbic acid and calcium
A.11.G.B Ascorbic acid in combination with other drugs
Pharmacodynamics:Correction of bone and cartilage tissue metabolism.
It replenishes the deficiency of ascorbic acid, calcium, vitamin D.
Ascorbic acid is involved in the formation of collagen and in oxidation-reduction reactions, enhances reparative processes in tissues, improves cellular respiration.
Calcium stimulates the formation of bone tissue, participates in the processes of blood coagulation, stabilizes the cardiac activity, carries out the transmission of nerve impulses.
Pharmacokinetics:Vitamin D absorbed in the gastrointestinal tract by 60-90%; in the state of hypovitaminosis - up to 99-100%. Circulates in plasma in the form of chylomicrons, deposited in bone and adipose tissue. Elimination with bile.
Ascorbic acid is completely absorbed from the gastrointestinal tract after ingestion. It binds to plasma proteins in 25%. Normally, the concentration of ascorbic acid in the blood: 15-20 mcg / ml. The concentration of ascorbic acid in erythrocytes and plasma is lower than in platelets and leukocytes.
Ascorbic acid is oxidized to dehydroascorbic acid,metabolized into inactive ascorbate-2-sulfate and oxalic acid, then excreted in the urine. In cases of exceeding the dose (more than 200 mg) ascorbic acid is eliminated by the kidneys in an unchanged form.
Indications:It is used to treat rickets and osteoporosis during the postmenopause, during treatment with glycocorticoids, with increased demand for calcium: pregnancy, lactation, intensive growth.
IV.E20-E35.E20 Hypoparathyroidism
IV.E20-E35.E20.1 Pseudohypoparathyroidism
IV.E50-E64.E55.0 Rickets active
XIII.M80-M85.M81 Osteoporosis without pathological fracture
XIII.M80-M85.M83 Osteomalacia in adults
XIV.N25-N29.N25.0 Renal osteodystrophy
Contraindications:Nephrolithiasis, chronic renal failure.
Individual intolerance.
Carefully:When hypercalcemia is prescribed in minimum doses (1/2 bag per 100 ml of water).
Pregnancy and lactation:Recommendations for Food and Drug Administration (US Food and Drug Administration) - Category B. It is used during pregnancy. Penetrates through the placenta, the blood-brain barrier and into breast milk, when taking therapeutic doses of harmful effects on the fetus and the newborn is not recorded.
Dosing and Administration:It is taken orally once a day. The contents of the sachet are dissolved in 100 ml of water.
The highest daily dose: 1 packet of the drug.
The highest single dose: 1 packet of the drug - contains 180 mg of ascorbic acid, 500 mg of calcium carbonate, 400 IU of colcalciferol.
Side effects:Dyspepsia.
Allergic reactions.
Overdose:Cases of overdose are not marked.
Interaction:Calcium interferes with the absorption of tetracycline antibiotics.
Thiazide diuretics increase the risk of hypercalcemia.
Fresh vegetable and fruit juices, alkaline drink - reduce the absorption of ascorbic acid in the gastrointestinal tract.
With the simultaneous use of the drug with acetylsalicylic acid, the effectiveness of vitamin C is reduced by one third due to a decrease in absorption in the gastrointestinal tract.
Special instructions:The drug is recommended for use in the period of premenopause for the prevention of osteoporosis.
It is taken during pregnancy and when breastfeeding for the purpose of preventing rickets.
It is not compatible with tetracycline antibiotics.