Included in the formulation
АТХ:C.05.C.A.51 Rutozide in combination with other drugs
Pharmacodynamics:Ascorbic acid is involved in the formation of collagen and in oxidation-reduction reactions, enhances reparative processes in tissues, improves cellular respiration.
Rutozid prolongs the action of ascorbic acid, neutralizing vitamin C oxidase.Has the properties of competitive antagonism with catechol-ortho-methyltransferase, enhancing the action of noradrenaline and adrenaline at the level of the microvascular bed. Reduces the permeability of the walls of the vessels and the filtration of water in the capillaries, inhibits the aggregation of erythrocytes.
Ascorbic acid and rutozide inhibit lipid peroxidation in cell membranes, absorbing free radicals.
Pharmacokinetics:Ascorbic acid is completely absorbed from the gastrointestinal tract after ingestion. It binds to plasma proteins in 25%. Normally, the concentration of ascorbic acid in the blood: 15-20 mcg / ml. The concentration of ascorbic acid in erythrocytes and plasma is lower than in platelets and leukocytes.
Ascorbic acid is oxidized to dehydroascorbic acid, metabolized to inactive ascorbate-2-sulfate and oxalic acid, then excreted in the urine. In cases of exceeding the dose (more than 200 mg) ascorbic acid is eliminated by the kidneys in an unchanged form.
Rutozid in 50% is absorbed in the digestive tract. The maximum concentration in the blood is reached in 8-12 hours after administration. The half-life is 16 hours.Metabolized in the liver, eliminated by the kidneys in the form of metabolites.
Indications:It is used for hypovitaminosis C and P, capillary damage to exo- and endotoxins, rheumatism and allergic diseases.
I.A30-A49.A38 Scarlet fever
I.A75-A79.A75 Typhus
IV.E50-E64.E54 Insufficiency of ascorbic acid
VII.H30-H36.H35.6 Retinal hemorrhage
I.B00-B09.B05 Measles
III.D65-D69.D69.3 Idiopathic thrombocytopenic purpura
XIV.N10-N16.N11 Chronic tubulointerstitial nephritis
XIV.N10-N16.N10 Acute tubulointerstitial nephritis
Contraindications:Dyspeptic disorders.
Individual intolerance.
Carefully:Hypercoagulation of the blood, thrombophlebitis, propensity to thrombosis.
Pregnancy and lactation:Recommendations for FDA - not defined. Data on the ingestion of rutoside in breast milk is not available. It is used in pregnancy and lactation.
Dosing and Administration:It is taken orally, 1-2 tablets per day. If necessary, the dose can be increased to 8 tablets.
The highest daily dose: 8 tablets for adults, 4 tablets for children.
The highest single dose: 2 tablets.
Side effects:Dyspeptic disorders are possible.
Allergic reactions.
Overdose:Cases of overdose are not described.
Interaction:Fresh vegetable and fruit juices, alkaline drink - reduce the absorption of ascorbic acid in the gastrointestinal tract.
With the simultaneous use of the drug with acetylsalicylic acid, the effectiveness of vitamin C is reduced by one third due to a decrease in absorption in the gastrointestinal tract.
The intake of ascorbic acid with iron preparations increases their effectiveness.
Reduces the effectiveness of heparin and indirect anticoagulants.
Reduces the effectiveness of neuroleptics - phenothiazine derivatives.
Reduces the chronotropic effect of isoprenaline.
Barbiturates accelerate the release of ascorbic acid in the urine.
Tetracycline increases the elimination of ascorbic acid.
Special instructions:Monitoring of kidney function and blood pressure in connection with increased synthesis of corticosteroid hormones.
Patients with high iron content should use minimal doses of the drug.