Azrerebol® (Aztreobol®)

Azrethaball® injected intravenously (struyno, drip) and intramuscularly.

The IV route is recommended in patients who require single doses of more than 1 g, septicemia, with peritonitis or other severe systemic or life-threatening infections.

Adults and children over 12 years of age for the treatment of urinary tract infections Azrerebol® is prescribed in a dose of 0.5-1.0 g IV or IM every 8-12 hours. For the treatment of moderate infections of other localizations, a dose of 1 g or 2 g every 8 or 12 hours is administered. In cases of severe or life-threatening infections and infections caused by R. aeruginosa, a single dose is increased to 2.0 g and administered iv at intervals of 6 or 8 hours.

The maximum daily dose of the drug should not exceed 8 g. The duration of antibiotic therapy is determined individually, based on the severity of the infection and the selected pathogens. The course of treatment depends on the severity of the infection; The drug should be continued for at least 48 hours after the disappearance of the clinical symptoms of the infection.

In renal failure, dose adjustment is required when creatinine clearance is less than or equal to 30 ml / min / 1.73 m².

Treatment begins with a loading (first) dose, which depends on the location and severity of the infection (see Table 1).

Table 1.

* - with severe infection - additionally 1/8 of the loading dose after each hemodialysis session.

The usual dosages of Azreaabol® children from 9 months. under 12 years old are 30 mg / kg every 8 hours IV. For the treatment of severe and life-threatening infections, 30 mg / kg is administered every 6 to 8 hours IV. The maximum dose of Azreaabol® is 120 mg / kg / day.

Rules for the preparation of solutions for intravenous and / or intramuscular injection

Intramuscular injection

For the / m introduction sterile Azreteabol® powder is dissolved in sterile water for injection or in a 0.9% solution of sodium chloride. The following minimum amounts of solvent is added directly to the vial of dry antibiotic powder: into a vial containing 0.5 g of Azreaabol® 1.5 ml into a vial containing 1.0 g of Azreaabol® 3.0 ml. Enter deeply intramuscularly into areas of the body with a pronounced muscular layer (upper-outer quadrant of the buttock or lateral surface of the thigh).It is recommended that an aspiration test be carried out to avoid undesirable introduction of the solution into the blood vessel.

Intravenous administration

For in / in the jet Azrerebol® is dissolved in sterile water for injection. The following minimum amounts of the solvent are added directly to the vial of dry antibiotic powder: into a vial containing 0.5 g Azreaabol® 6 ml per vial containing 1.0 g Azrethabol® 10 ml. Enter iv slowly, for 3-5 min; it is possible to administer through a special node or port for injection of a system for intravenous infusions if the patient receives parenterally compatible fluids with Azrethabol.

For in / in the drip Azrerebol ® is dissolved in two stages:

1. sterile water for injection is used for initial dissolution, 3 ml of solvent per gram of Azrethabol®;

2. the resulting solution is transferred to a vial containing 50-100 ml of a compatible infusion medium. Enter through the system for IV infusions for at least 30 minutes. Azreaabol® solutions are compatible with 0.9% sodium chloride solution (recommended), 5% dextrose solution (recommended), 10% dextrose solution; aqueous solution,containing 0.45% sodium chloride and 5% dextrose; an aqueous solution containing 0.9% sodium chloride and 5% dextrose; an aqueous solution containing 0.2% sodium chloride and 5% dextrose; Ringer's solution; lactated Ringer's solution; sodium lactate solution for injection; solutions of Normozol, Normozol-R, Normozol-M with 5% glucose; 5% and 10% solutions of mannitol; 10% solution of invert sugar; solution of Ionosol with 5% glucose; solutions Isolit E and Izolit M with 5% glucose.