The frequency is classified according to the headings, depending on the occurrence of the case: very often (> 1/10), often (<1 / 10-> 1/100), infrequently (<1 / 100-> 1/1000), rarely (<1 / 1000-> 1/10000), very rarely (<1/10000).
Violations of the blood and lymphatic system: infrequently: Anemia (including aplastic and hemolytic anemia); rarely: neutropenia, a decrease in hemoglobin and hematocrit, thrombocytopenia, agranulocytosis, suppression of bone marrow function, pancytopenia, enlarged lymph nodes, autoimmune diseases.
Disorders of metabolism and nutrition: infrequently - hypoglycemia.
From the side of the central nervous system: often - headache, depression; infrequently - confusion, drowsiness, insomnia, increased excitability, paresthesia, dizziness; rarely - a change in the nature of dreams, sleep disturbances.
From the side of the organ of vision: Often: violation of accommodation.
From the side of the cardiovascular system: Often - dizziness; often - marked decrease in blood pressure, syncope, myocardial infarction or cerebral stroke, chest pain, heart rhythm disturbances, angina pectoris, tachycardia; infrequently: orthostatic hypotension, palpitation; rarely - Raynaud's syndrome.
From the respiratory system: Often - cough; often - dyspnoea; infrequently: rhinorrhea, sore throat and hoarseness, bronchospasm / bronchial asthma; rarely- pulmonary infiltrates, rhinitis, allergic alveolitis / eosinophilic pneumonia.
From the digestive system: Often - nausea; often - diarrhea, abdominal pain, change in taste perception; infrequently - intestinal obstruction, pancreatitis, vomiting, indigestion, constipation, lack of appetite, irritation of the stomach, dryness of the oral mucosa, peptic ulcer; rarely - stomatitis / aphthous ulcers, glossitis; rarely - angioedema of the intestine.
From the liver and bile excretory system: rarely - hepatic insufficiency, hepatitis - hepatocellular or cholestatic, including hepatic necrosis, cholestasis (including jaundice).
From the skin and subcutaneous fat: often - skin rash, hypersensitivity reactions / angioedema: reported angioedema with involvement of the face, limbs, lips, tongue, vocal folds and / or larynx; infrequently: increased sweating, itching, hives, alopecia; rarely - erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, pemphigus, erythroderma.
A symptom complex has been reported that may be accompanied by some and / or all of the following side effects: fever, serositis, vasculitis,
myalgia / myositis, arthralgia / arthritis, an increase in the titer of antinuclear antibodies (ANA), an increase in the rate of erythrocyte sedimentation, eosinophilia, and leukocytosis. There may be a skin rash, photosensitivity or other skin manifestations.
From the side of the urinary system, infrequently - impaired renal function, renal failure, proteinuria; rarely - oliguria.
On the part of the reproductive system and mammary glands: infrequently - impotence; rarely - gynecomastia.
Violations of a general nature: very often - asthenia; often - fatigue; infrequently - muscle cramps, redness of the skin of the face, tinnitus, discomfort, fever.
Laboratory indicators often - hyperkalaemia, increased serum creatinine concentration; infrequently - increased serum urea concentration, hyponatremia; rarely - Increased activity of "liver" transaminases, hyperbillirubinemia.