Betamethasone + Calcipotriol (Betamethasonum + Calcipotriolum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Dermatotropona funds

Included in the formulation
  • Daivobet®
    ointment externally 
    Leo Pharmaceutical Products Co., Ltd. A / S (Leo Pharma A / S)     Denmark
    • АТХ:

    D.05.A.X.52   Calcipotriol in combination with other drugs

    Pharmacodynamics:

    Combined preparation for topical application.

    Betamethasone

    Has anti-inflammatory, antipruritic, anti-allergic, decongestant and vasoconstrictive. It prevents the accumulation of neutrophils on the skin, reducing inflammatory exudate and production of lymphokines, inhibits the migration of macrophages, reduces the processes of infiltration and granulation.

    By inhibition of phospholipase A activity2 and reducing the release of arachidonic acid from the phospholipids of cell membranes reduces the production of leukotrienes and prostaglandins. Reduces the main substance of the connective tissue, weakening the exudative and proliferative processes in the skin. Inhibits cellular kinins, which have proteolytic activity.

    Calcipotriol

    Synthetic analogue of the active metabolite of vitamin D, regulates the exchange of calcium and phosphorus. Interacts with vitamin receptors D, selectively activating the response mediated by vitamin D: inhibits the proliferation of keratinocytes, thereby accelerating their morphological differentiation.

    Pharmacokinetics:

    Means for external use, practically not absorbed into the bloodstream and does not have a systemic effect.

    Indications:

    It is used for the treatment of vulgar psoriasis.

    ICD-10

    XII.L40-L45.L40   Psoriasis

    Contraindications:

    Psoriatic erythroderma, teardrop, exfoliative, pustular psoriasis.

    Varicella, skin tuberculosis, cutaneous manifestations of syphilis, herpes simplex, individual intolerance, age under 18 years, marked renal and hepatic insufficiency.

    Carefully:

    Pregnancy, hypersensitivity.

    Pregnancy and lactation:

    Recommendations for FDA - Category C. It is used with caution during pregnancy and lactation in cases where the intended benefit exceeds the risk to the fetus and newborn.

    Dosing and Administration:

    Ointment is applied a thin layer on the affected skin areas 1 time per day for 4 weeks. Area of ​​application - not more than 30% of the body surface.

    The highest daily dose: 15 g.

    The highest weekly dose: 100 g.

    Side effects:

    Allergic reactions.

    Overdose:

    Hypercalcemia, exacerbation of diabetes mellitus, secondary skin infection.

    Treatment is symptomatic, drug cancellation.

    Interaction:

    Clinically significant interaction is not described.

    Special instructions:

    It is not recommended to apply ointment on the mucous membranes, scalp and face.

    Instructions
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