Betamethasone + Chlorhexidine (Betamethasonum + Chlorhexidinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Glucocorticosteroids

Antiseptics and disinfectants

Included in the formulation
АТХ:

D.07.B.C   Highly active corticosteroids in combination with antiseptics

D.07.B.C.01   Betamethasone in combination with antiseptics

Pharmacodynamics:

Combined drug, the effect of which is due to the components that make up its composition.

Betamethasone - glucocorticosteroid, has a local anti-inflammatory, antiallergic, antipruritic, decongestant and antiproliferative action. Has a stronger vasoconstrictive effect than other fluoride derivatives of glucocorticosteroids, systemic effects are expressed only slightly due to limited absorption through the skin. When exposed to the skin, the edge accumulation of neutrophils is prevented, which leads to a decrease in exudation, production of cytokines, inhibition of migration of macrophages, leading ultimately to a decrease in the processes of infiltration and granulation.

Chlorhexidine is an antimicrobial drug that acts on gram-positive and gram-negative microorganisms, yeast, dermatophytes.

Pharmacokinetics:

Data on pharmacokinetics are not available.

Indications:

Inflammatory and allergic dermatoses,complicated by secondary infection and prevention of secondary infection: psoriasis; parapsoriasis; lipoid necrobiosis; contact dermatitis; atopic dermatitis; eczema; neurodermatitis; seborrheic dermatitis; erythroderma; ring-shaped erythema; erythema nodosum; lymphocytoma; benign lymphoplasia; phlebotoderma; exfoliative dermatitis; herpetiform dermatitis; radiation dermatitis; discoid lupus erythematosus; itching of various etiologies (including itching of the anus and external genitalia, senile itching).

ICD-10

XII.L10-L14.L13.0   Dermatitis herpetiformis

XII.L20-L30.L20.8   Other atopic dermatitis

XII.L20-L30.L21   Seborrheic dermatitis

XII.L20-L30.L23   Allergic contact dermatitis

XII.L20-L30.L24   Simple irritant contact dermatitis

XII.L20-L30.L28.0   Simple chronic lichen

XII.L20-L30.L29   Itching

XII.L20-L30.L29.3   Anogenital itching, unspecified

XII.L20-L30.L30.0   Coin-like eczema

XII.L40-L45.L40   Psoriasis

XII.L40-L45.L41   Parapsoriasis

XII.L40-L45.L43   Lichen red flat

XII.L50-L54.L53   Other erythematous conditions

XII.L55-L59.L58   Radiation dermatitis radiation

XII.L80-L99.L93.0   Discoid lupus erythematosus

Contraindications:

TOsevere manifestations of syphilis; lupus; viral skin lesions; trophic ulcers of the lower leg,associated with varicose veins; neoplasm of the skin; rosacea, vulgar acne, postvaccinal skin reactions; in children under 1 year old - a rash (against the background of diaper rash); hypersensitivity to the components of the drug.

Carefully:

With prolonged use or application on large surfaces of the skin.

Pregnancy and lactation:

The safety of the use of local glucocorticosteroids in pregnant women is not established. The purpose of this group of medicines during pregnancy is justified only if the potential benefit exceeds the potential risk to the fetus.

Dosing and Administration:

External means. The cream is applied in a thin layer, rubbing, on the affected skin 2-3 times a day; in mild cases - 1 time per day. In cases that are difficult to treat, it is possible to use occlusive dressings (excluding children).

Have children and the patients with lesions leather person treatment course should not exceed 5 days.

Side effects:

Burning, itching, steroid acne, striae, dry skin, folliculitis, hypertrichosis, sweating.

With prolonged use - skin atrophy, local hirsutism, telangiectasia, purpura,hypopigmentation; when applied to large surfaces, systemic manifestations characteristic of glucocorticosteroids are possible.

Overdose:

PIn the long-term use of the drug in high doses, the development of symptoms of hypercorticism is possible.

Treatment: conduct symptomatic therapy. It is recommended to gradually stop the drug. If necessary, correct the electrolyte balance.

Interaction:

Chlorhexidine is incompatible with detergents containing an anionic group (saponins, sodium lauryl sulfate, sodium carboxymethylcellulose) and soaps. The presence of soap can inactivate chlorhexidine, so before using the drug, soap residues should be thoroughly rinsed.

Special instructions:

Avoid contact with eyes and mucous membranes. When using the drug on large surfaces and / or with an occlusive dressing, it is necessary to keep in mind the possibility of developing a systemic action of betamethasone. In case of application of the drug with ordinary or rosaceous acne, the exacerbation of the disease is possible.

Instructions
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