Bystrum Sprint - instructions for use, dose, side effects, contraindications

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Dosage form: & nbspgel for external use

Composition:

Composition per 100 g of gel:

Active substances: heparin sodium 50,000 IU, dexpanthenol in terms of 100% substance 2.50 g, dimethylsulfoxide in terms of 100% substance 15.00 g; Excipients: carbomer interpolymer (type A), trometamol, macrogol glyceryl hydroxy stearate, isopropanol, rosemary oil, common pine trees, citronella oil, purified water.

Description:

Transparent gel from colorless to light yellow color. A characteristic odor is allowed.

Pharmacotherapeutic group:Anticoagulant direct action for topical application + other drugs

ATX: & nbsp

Heparin in combination with other drugs

Pharmacodynamics:

Combined drug, the effect of which is due to the its composition by components.

Dimethylsulfoxide (DMSO)

DMSO has anti-inflammatory, anti-edematous and local anesthetic effect. Anti-inflammatory activity is associated with some pharmacological effects, the most significant of which is the inactivation of hydroxyl radicals, which are produced in large quantities during the inflammation process and have a destructive effect on the tissue.DMSO has a local analgesic effect by reducing the rate of nociceptive (pain) impulses in peripheral neurons. Anti-edematous action is provided by inactivation of hydroxyl radicals and improvement of subcutaneous metabolic reaction at the place of application of the drug. To a certain extent, the hygroscopic properties of DMSO are also responsible for its anti-edematous effect. DMSO (from 50% or more) penetrates through biological membranes, incl. through the skin, promoting better and deeper penetration into the tissues of other medicines used simultaneously with it.

Heparin

Heparin has an anti-inflammatory effect, promotes the regeneration of connective tissue due to inhibition of hyaluronidase activity. Heparin exhibits a dose-dependent antithrombotic effect, enhancing the inhibitory activity of antithrombin III on the activation of prothrombin and thrombin. The penetration of heparin through healthy skin is dose-dependent and is confirmed for dosage starting at 300 IU / g.

Dexpanthenol

With topical application dexpanthenol is transformed in the skin into pantothenic acid (vitamin B).The efficacy of dexpanthenol is comparable to that of pantothenic acid. Pantothenic acid as a component of coenzyme A participates in various catabolic and anabolic processes in tissues, due to the improvement of granulation and epithelization processes promotes the regeneration of damaged skin areas.

Pharmacokinetics:

Dimethylsulfoxide (DMSO)

The physiological concentration of DMSO in normal blood plasma is 40 ng / ml. After 6 hours after application, the maximum concentration in the blood plasma reaches 120 ng / ml and remains up to 12 hours after application. After 60 hours after application, the concentration of DMSO in blood plasma reaches a physiological level of 40 ng / ml. 12-25% of absorbed DMSO is excreted within the first 24 hours and 37-48% is excreted for 7 days unchanged through the kidneys or in the form of a metabolite (dimethylsulfone). 3.5-6% of total DMSO is excreted through the lungs in the form of dimethyl sulfide 6-12 hours after application of the drug. When applied to 1 g of DMSO 3 times a day for 5 days, its average content at the site of application on the skin is 3 mg / g, the average content in the underlying muscle tissue and synovial membrane at the site of the synovial compound is 7-10 μg / ml, of the liquid is 0.8 μg / g.The concentration of DMSO in blood plasma is 0.5 μg / g. The half-life of DMSO is 11-14 hours.

Heparin

With external application, heparin is absorbed only slightly.

Dexpanthenol

With external application dexpanthenol is transformed in the skin into pantothenic acid. Good absorption of dexpanthenol is documented.

Indications:

- Edema, bruising and inflammation of soft tissues, muscles, tendons, tendon sheaths;

- Closed injuries, bruises;

- Injuries of joints with sprains of ligaments and tendons;

- Epicondylitis of the shoulder ("elbow tennis player"), tendinitis (inflammation of the tendons), tendovaginitis (inflammation of the tendon sheaths), bursitis (inflammation of the mucous bag of the joint);

- Periarthritis of the shoulder joint;

- Acute neuralgia.

Contraindications:

- Hypersensitivity to any of the components of the drug;

- bronchial asthma;

- severe violations of the liver, kidneys;

- severe cardiovascular system disorders;

- open wounds at the site of application;

- pregnancy and the period of breastfeeding;

- children under 5 years.

Pregnancy and lactation:

Pregnancy

Since the research data on the use of the drug in pregnant women are not available, its use during pregnancy is contraindicated.

Breastfeeding period

Dimethylsulfoxide penetrates into breast milk, so during the use of the drug, breastfeeding should be discontinued.

Dosing and Administration:

Outwardly.

The drug should be applied on the skin over the affected area of the skin 2-4 times a day for 7-10 days or until the symptoms disappear (pain, swelling, inflammation). If the gel does not show a clear improvement within 10 days, it is recommended to consult a doctor.

When applying the gel under the bandage, apply the gel and wait a few minutes for it to be absorbed by the skin and evaporate the isopropanol. Then you can apply a hermetically sealed bandage.

Bystrum Sprint can be used for iontophoresis. The drug is applied to the cathode. Bystrum Sprint as contact gel can be used in ultrasound therapy (phonophoresis). The active substances of the gel supplement the therapeutic effect of ultrasonic waves.

The drug should be used according to the indications, the method of administration and the dosages indicated in this manual for the medical use of the drug. The duration of treatment depends on the severity of the symptoms and the severity of the disease.

Side effects:

Possible local skin reactions (redness, itching, burning sensation in place gel application), which usually disappear during further treatment.

Due to the content of DMSO or other components of the drug, it is sometimes possible to develop a skin allergic reaction.

In rare cases, during the use of the drug in some patients may appear a smell from the mouth. The smell is caused by dimethyl sulphide, which is a product of the metabolism of dimethylsulfoxide.

Perhaps a change in taste, disappearing a few minutes after applying the gel.

In isolated cases, the occurrence of allergic reactions of an immediate type (urticaria, Quincke's edema) is possible.

It is extremely rare when applying the drug to large areas of the body may cause nausea, diarrhea, difficulty breathing, headache, chills.

If you experience any of the side effects indicated in the instructions or are aggravated, and if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Data on drug overdose are absent. In case of an overdose of the drug, you should immediately call your doctor.

Interaction:

The application of another drug simultaneously with the drug can enhance their permeability through the skin. With the simultaneous use of the drug and a non-steroidal anti-inflammatory drug sulindac, the development of peripheral neuropathy is possible.

If you use the above or other medications (including OTC drugs), consult your doctor before applying the drug "Bystrum Sprint".

Special instructions:

Place the application of the gel should be free of other medicines. The drug should not be applied to the mucous membranes of the eyes, nose, mouth, open wounds or damaged skin areas (due to irradiation, severe sunburn, post-operative scars).

During the treatment, the photosensitivity of the skin can be intensified, therefore, during the period of application, intensive sunbathing and visiting the solarium should be limited. In case of skin reactions, treatment should be stopped. Due to the high absorption of dimethyl sulphoxide, the drug should not be used in combination with other ointments and gels.

Do not exceed the maximum periods and recommended doses for self-administration of the drug.If there is no effect or if the symptoms of the disease worsen, it is recommended to consult a doctor.

Effect on the ability to drive transp. cf. and fur:

Does not affect.

Form release / dosage:

Gel for external use.

Packaging:

For 50 or 100 g in an aluminum tube.

Each tube together with the instruction for use is placed in a pack of cardboard.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-004443

Date of registration:01.09.2017

Expiration Date:01.09.2022

The owner of the registration certificate:AKRIKHIN HFK, JSC AKRIKHIN HFK, JSC Russia

Manufacturer: & nbsp

AKRIKHIN HFK, JSC Russia

Information update date: & nbsp28.09.2017

Illustrated instructions

Instructions

Bystrum Sprint (Bystrum Sprint)