Bromoanilide diethylaminopropanoic acid (Acidum bromaniliddiaethylaminopropanicum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Local Anesthetics

Included in the formulation
АТХ:

N.01.B.X   Other drugs for local anesthesia

Pharmacodynamics:

Reversibly blocks the potential-dependent sodium channels, which inhibits the generation of pulses in the endings of the sensory nerves and their conduction along nerve fibers. It suppresses pain and other impulses, depresses the central nervous system when it enters the systemic circulation.

Moderately reduces blood pressure, usually in patients with cardiovascular pathology.

It has an anti-inflammatory effect and shortens the epithelization time (when applied to mucous membranes).

Pharmacokinetics:

The time of onset and duration of local anesthesia depends on the route of administration and the dose for conductive anesthesia - 10-20 minutes and 1.5-2 hours, for spinal cord - 6-10 minutes and 0.5-1.5 hours, with epidural - 25-30 minutes and 1 hour, with infiltration several minutes and 1-1.5 hours.

Indications:

Injection: conductor anesthesia (including large nerves and nerve plexuses), andinfiltration anesthesia (hernia repair, appendectomy, correction of dislocations, fractures of bones, etc.), epidural and spinal anesthesia.

A solution for external use is used for surface (terminal) anesthesia of mucous membranes.

In ENT-practice: carrying out various manipulations in the nasal cavity and ear - probing, catheterization, removal of polyps, electrocoagulation of bleeding areas of the nasal mucosa, puncture of the maxillary sinuses.

In dentistry: aphthous stomatitis, bubble lichen, pulpitis.

In urology: catheterization.

In proctology: rectal cracks, proctitis, anal itching, epithelial coccygeal passage, period after hemorrhoidectomy.

Fibrobroncho- and fibrogastroscopy, etc.

In anesthesiology: application to the intubation tubes before intubation of the trachea.

ICD-10

XVIII.R50-R69.R52   Pain, not elsewhere classified

XXI.Z00-Z13.Z01.2   Dental examination

XXI.Z00-Z13.Z01.8   Other specified special examination

XXI.Z40-Z54.Z40   Prophylactic surgical intervention

Contraindications:

Individual intolerance; sinus bradycardia; for injections - age up to 14 years.

Carefully:

Use with caution in patients prone to allergic reactions.

Renal and hepatic insufficiency requires a dose reduction.

When combined with epinephrine, it is important to remember the possibility of cardiotropic effects.

Pregnancy and lactation:

There is no data on the use in pregnancy and lactation.

Dosing and Administration:

Injection

Infiltration anesthesia: 1% solution up to 200 ml, the maximum dose for adults is 2 g.

Conduction Anesthesia: 2% solution - 20-25 ml or 1% solution up to 100 ml. The maximum dose should not exceed 1 g.

Spinal-cerebral anesthesia: 2% solution - 4-6 ml.

Epidural anesthesia: 2% - 30-35 ml.

A combination with 0.1% solution of epinephrine (0.1-0.15 ml per 20-25 ml of anilocaine solution) is allowed to increase the duration of action and reduce absorption from the injection site.

Solution for external use

Surface anesthesia: locally, 5% solution is applied to the mucous membranes once in a volume of 4-30 ml (based on 200-1500 mg of anilocaine).

Side effects:

Injection: dizziness, general weakness, depression blood pressure. Solution for external use: allergic reactions.

Overdose:

When an overdose is observed general weakness, pale skin of the face and mucous membranes, dizziness, nausea and vomiting, arrhythmia, lowering blood pressure right up to collapse, motor excitement, convulsions.For treatment, it is necessary to give up the drug, maintain adequate oxygenation, intravenous the introduction of short-acting agents for anesthesia.

Interaction:

The drug intensifies the inhibitory effect on central nervous system other local anesthetics, hypnotics, funds for anesthesia, sedatives, tranquilizers, narcotic analgesics. Epinephrine increases the duration and severity of the effect.

Special instructions:No data.
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