Alfentanil, eletriptan - decrease in the clearance of these funds.
Astemizole, terfenadine, cisapride, pimozide - increasing their concentration in the blood, lengthening the interval Q-T (sudden arrhythmic death possible). Joint use is contraindicated!
Atorvastatin, lovastatin, simvastatin - increase in their concentrations in the plasma, the development of rhabdomyolysis. Joint use is contraindicated!
Budesonide, dexamethasone, methylprednisolone - slowing the metabolism of glucocorticosteroids.
Buspirone - a significant increase in the concentration of buspirone in the blood.
Busulfan, docetaxel, vinca alkaloids - inhibition of the metabolism of these agents.
Warfarin - strengthening of anticoagulant action.
Hypoglycemic agents (sulfonylureas, for example glibenclamide) - increasing their concentration in the blood, the development of hypoglycemia.
Digoxin - increased concentration in the blood and toxicity.
Dysopyramide - risk of lengthening the interval Q-T.
Indinavir, ritonavir, saquinavin - a mutual increase in plasma concentrations.
Macrolides (erythromycin, clarithromycin) - increased concentration and toxicity of butoconazole.
Polyene antifungal agents, including amphotericin B, reduce the activity of polyene antibiotics.
Rifampicin, isoniazid - a decrease in the concentration of azoles in the blood, inefficiency or exacerbation of the infection.
Phenytoin - increasing its concentration in the blood, efficiency and toxicity.
Quinidine - increasing its concentration in the blood and the risk of cardiovascular complications. Joint use is contraindicated!
Cyclosporine, tacrolimus - increase of their toxicity (nephro- and hepatotoxicity).