Dentamet® (Dentamet®)

Combined antimicrobial preparation. The effectiveness of the drug is due to the presence in its composition of active ingredients, such as metronidazole and chlorhexidine.

Metronidazole - a derivative of nitroimidazole, which has antiprotozoal and antibacterial action against anaerobic protozoa and anaerobic bacteria that cause periodontitis: Porphyromonas gingivalis, Prevotella intermedia, Prevotella denticola, Fusobacterium fusiformis, Wolinella recta, Treponema spp., Eikenella corrodens, Borrelia vincenti, Bacteroides melaninogenicus, Selenomonas spp. Inactive against aerobic bacteria. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa.The reduced 5-nitro group of metronidazole reacts with the DNA of a cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

Chlorhexidine - a disinfectant, active against a wide range of vegetative forms of gram-negative and gram-positive microorganisms, yeast, dermatophytes and lipophilic viruses. On bacterial spores acts only at elevated temperature. The bactericidal effect is due to cation binding (the result of dissociation salts of chlorhexidine in a physiological environment) with negatively charged walls of bacterial cells and extramicrobial complexes. In low concentrations, disrupting the osmotic equilibrium of bacterial cells and the release of K + and phosphorus from them, has a bacteriostatic effect; at high cytoplasmic concentrations: the contents of the bacterial cell are deposited, leading ultimately to the death of bacteria.