Derinat - instructions for use, dose, side effects, contraindications

Active substanceSodium deoxyribonucleateSodium deoxyribonucleate

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solution w / m

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Dosage form: & nbspRAsterol for intramuscular injection

Composition:

Active substance: sodium deoxyribonucleate 1.5 g.

Excipients: sodium chloride 0.9 g, water for injection - 100 ml.

Description:Pcolorless liquid.

Pharmacotherapeutic group:Immunomodulating agent

ATX: & nbsp

L.03.A.X Other immunostimulants

Pharmacodynamics:

The drug activates the processes of cellular and humoral immunity. Immunomodulating effect is caused by stimulation of B-lymphocytes, activation of T-helpers. Derinat® activates nonspecific resistance of the body, optimizing inflammatory responses, and immune response to bacterial, viral and fungal antigens. Stimulates reparative and regenerative processes. Increases the resistance of the body to infections, regulates hematopoiesis (helps normalize the number of leukocytes, lymphocytes, granulocytes, phagocytes, platelets). Possessing a pronounced lymphotropic activity, Derinat® stimulates the drainage-detoxification function of the lymphatic system.Derinat® significantly reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs and radiation therapy. The drug does not have embryotoxic, teratogenic and carcinogenic effects.

Pharmacokinetics:

Suction and distribution

The drug is rapidly absorbed and distributed in organs and tissues involving the endolymphatic pathway. Has a high tropism to the organs of the hematopoietic system, takes an active part in cellular metabolism, integrating into cellular structures. In the phase of intensive drug delivery to the blood, a redistribution occurs between the plasma and the formed elements of the blood, in parallel with the metabolism and excretion. After a one-time injection, all pharmacokinetic curves describing the change in drug concentration in the organs and tissues studied are characterized by a rapid increase phase and a fast phase of decreasing concentration in the time interval 5-24 hours. The half-life (T_1/2) with intramuscular injection is 72.3 hours. Derinat® is quickly distributed throughout the body, in the course of daily course use, it is cumulated in organs and tissues: maximum: - in the bone marrow, lymph nodes, spleen,thymus; to a lesser extent - in the liver, brain, stomach, small and large intestine. The maximum concentration in the bone marrow is determined after 5 hours, after the administration of the drug. The drug overcomes the hemato-encephalic barrier. The maximum concentration of the drug in the brain is reached after 30 minutes.

Metabolism and excretion

Derinat® is metabolized in the body. Excreted from the body (in the form of metabolites) partially with feces, and, to a greater extent, with urine according to biexponential dependence.

Indications:

- Radiation damage;

- violation of hemopoiesis;

- mielodepression and resistance to cytostatics in cancer patients, developed against a background of cytostatic and / or radiation therapy (stabilization of hemopoiesis, reduction of cardio- and myelotoxicity of chemotherapy drugs);

- stomatitis, induced by cytostatic therapy;

- peptic ulcer of stomach and duodenum, erosive gastroduodenitis;

- cardiac ischemia;

- obliterating diseases of the vessels of the lower extremities, chronic ischemic disease of the lower limbs of the II-III stage;

- trophic ulcers, long-term non-healing wounds;

- odontogenic sepsis, purulent-septic complications;

- rheumatoid arthritis;

- burn disease;

- preoperative and postoperative periods (in surgical practice);

- endometritis, salpine oophoritis, endometriosis, fibroids;

- Chlamydia, ureaplasmosis, mycoplasmosis;

- prostatitis, benign prostatic hyperplasia;

- chronic obstructive pulmonary disease;

- tuberculosis of the lungs, inflammatory diseases of the respiratory tract.

Contraindications:

Individual intolerance.

Pregnancy and lactation:

Consultation of the doctor is necessary.

If it is necessary to prescribe the drug during pregnancy, the expected benefit for the mother and the potential risk to the fetus should be assessed.

In the lactation period, use strictly according to the doctor's prescription.

Dosing and Administration:

Adults: intramuscularly for 1 to 5 minutes 1.5 ml (75 mg) of the solution, with an interval of 24-72 hours.

With ischemic heart disease - 10 injections with an interval of 48-72 hours.

With gastric ulcer and 12 duodenum - 5 injections with an interval of 48 hours.

With oncological diseases - 3-10 injections with an interval of 24-72 hours.

In gynecology (endometritis, chlamydia, ureaplasmosis, mycoplasmosis, salpinoophoritis, fibroids, endometriosis) - 10 injections with an interval of 24-48 hours.

In andrology (prostatitis, benign prostatic hyperplasia) - 10 injections with an interval of 24-48 hours.

With pulmonary tuberculosis - 10-15 injections with an interval of 24-48 hours.

In acute inflammatory diseases - 3-5 injections with an interval of 24-72 hours.

In chronic inflammatory diseases - 5 injections with an interval of 24 hours, then - 5 injections, with an interval of 72 hours.

When using a 1.5% solution of 2 ml, intramuscular injections should be performed daily, making a recalculation, until the exchange rate reaches 375-750 mg.

Children the drug is administered intramuscularly according to the same scheme as the adult. Children up to 2 years of age, the drug is prescribed in a single dose of 7.5 mg (0.5 ml). In children from 2 to 10 years of age, a single dose is calculated based on 0.5 ml of the drug for a year of life. From the age of 10, a single dose of 5 ml of a 1.5% solution, the course dose - up to 5 injections (15 mg / ml) of the drug.

Side effects:

Patients with diabetes mellitus have a hypoglycemic effect, which should be taken into account by controlling the level of sugar in the blood.

Overdose:

There were no negative effects from an overdose.

Interaction:

Application of Derinat® in complex therapy allows to increase efficiency and shorten the duration of treatment,with a significant reduction in doses of antibiotics and antiviral agents with an increase in remission periods.

Derinat® increases the effectiveness of antitumor antibiotics of the anthracycline series, cytostatics.

The drug potentiates the therapeutic effect of basic therapy for stomach ulcer and duodenal ulcer.

Derinat® reduces the iatrogenicity of basic drugs in the treatment of rheumatoid arthritis with a 50% and 70% improvement in a number of complex indicators of disease activity.

With surgical sepsis, the introduction of Derinata® into the complex therapy causes a decrease in the level of intoxication, activation of immunity, normalization of hematopoiesis, improves the functioning of organs responsible for detoxifying the internal environment of the body (lymph nodes, spleen, etc.).

Special instructions:

The drug may be administered subcutaneously.

Form release / dosage:Solution for intramuscular injection, 15 mg / ml.

Packaging:

5 ml in bottles of imported glass with injection infusion stoppers in pallets-blisters in cardboard pack No. 5 or 2 ml in bottles of imported glass with injection infusion stoppers in blister pallets in cardboard pack No. 10.

Storage conditions:

Store in a dark place out of the reach of children, at a temperature of + 4 ° C to + 20 ° C.

Shelf life:

5 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N002916 / 01

Date of registration:27.02.2008 / 14.07.2016

Expiration Date:Unlimited

The owner of the registration certificate:FarmPack, LLCFarmPack, LLC Russia

Manufacturer: & nbsp

Immunnoleks FZ, LLC Russia

Representation: & nbspImmunnoleks FZ, LLCImmunnoleks FZ, LLCRussia

Information update date: & nbsp24.03.2017

Illustrated instructions

Instructions

Derinat® (Derinat®)