Dihydroergocristine + Clopamid + Reserpine (Dihydroergocristinum + Clopamidum + Reserpinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Sympatholytics

Diuretics

Alpha-blockers

Included in the formulation
  • Brinerdin®
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    KRKA, dd, Novo mesto, AO    
    • АТХ:

    C.02.L.A.51   Reserpine and diuretics in combination with other drugs

    Pharmacodynamics:

    Dihydroergocristine

    The dihydrated ergot derivative inhibits α-adrenoceptors, causing the peripheral vessels to expand and lower blood pressure. Being an agonist of serotonin 5-HT1receptors, has a regulating effect on the tone of the brain vessels: reduces the aggregation of erythrocytes and platelets, reduces the permeability of the vascular walls, increases the number of functioning capillaries, improves blood circulation and metabolic processes in the brain, increases the resistance of brain tissue to hypoxia.

    Klopamid

    A non-azidic diuretic of medium strength, stimulates the excretion of sodium, chlorine, potassium, magnesium and water ions, preserves calcium ions. Due to the lower sodium content in the vascular wall, the sensitivity of the baroreceptors to vasoconstrictor influences decreases.

    Reserpine

    Rauwolfia alkaloid, sympatholytic, reduces the amount of norepinephrine mediator in varicose thickenings, which inhibits the transfer of excitation to effector organs from the end of postganglionic adrenergic fibers.As a result, it removes the influence of sympathetic innervation on the heart and blood vessels: reduces the strength and frequency of heartbeats, dilates blood vessels, lowers blood pressure.

    Increases the secretion of hydrochloric acid in the stomach, increases the peristalsis of the gastrointestinal tract, causes hypothermia, miosis. It improves renal blood flow, increases glomerular filtration.

    Pharmacokinetics:

    Dihydroergocristine

    After oral administration, an empty stomach is absorbed up to 25% in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 1 hour. The connection with plasma proteins is 68%.

    Penetrates through the blood-brain and placental barrier, is found in breast milk. Metabolism in the liver.

    The half-life is 6-7 days. Elimination by the kidneys.

    Klopamid

    After oral administration, up to 90% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 2 hours. The connection with plasma proteins is 46%.

    Metabolism in the liver.

    The half-life is 6-7 days. Elimination by the kidneys.

    Reserpine

    After oral administration, an empty stomach is absorbed up to 40% in the gastrointestinal tract.The maximum concentration in the blood plasma is achieved in 1-3 hours. Does not bind to plasma proteins.

    Therapeutic effect develops after the reception. Penetrates through the blood-brain and placental barrier, is found in breast milk. Metabolism in the liver.

    The half-life is 271 hours. Elimination by the kidneys.

    Indications:

    It is used for the treatment of arterial hypertension.

    ICD-10

    IX.I10-I15.I10   Essential [primary] hypertension

    IX.I10-I15.I15   Secondary Hypertension

    Contraindications:

    Pheochromocytoma, depression, peptic ulcer of the stomach and duodenum in the period of exacerbation, severe renal and hepatic insufficiency, arterial hypotension, angle-closure glaucoma, bronchial asthma, Addison's disease, pregnancy and lactation, age to 18 years, individual intolerance.

    Carefully:

    Gout, hypersensitivity.

    Pregnancy and lactation:

    Recommendations for FDA - category D. Contraindicated in pregnancy and lactation.

    Dosing and Administration:

    Inside, 1 tablet a day. It is possible to increase the dose to 2-3 tablets per day.

    The highest daily dose: 3 tablets.

    The highest single dose: 1 dragee.

    Side effects:

    Central and peripheral nervous system: asthenia, headache, dizziness, anxiety, paresthesia, insomnia, hallucinations.

    Respiratory system: stuffy nose, rarely - bronchospasm.

    Hemopoietic system: thrombocytopenia.

    The cardiovascular system: arterial hypotension, thoracology.

    Digestive system: decreased appetite, nausea, vomiting, diarrhea.

    Musculoskeletal system: myasthenia gravis, tetany.

    Dermatological reactions: itching.

    Sense organs: hyperemia of the eye mucosa, spasm of accommodation, miosis.

    Urinary system: violation of urination.

    Reproductive system: decreased libido, galactorrhea.

    Allergic reactions.

    Overdose:

    Parkinsonism, nightmarish dreams, arrhythmias, depression, bradycardia, hyporeflexia, confusion, coma.

    Treatment is symptomatic.

    Interaction:

    Strengthens the action of adrenomimetics, barbiturates, antihistamines, ethanol, funds for inhalation anesthesia.

    Increases the inhibitory effect on the central nervous system when used simultaneously with monoamine oxidase inhibitors, also increases the risk of hyperreflexia,arterial hypotension.

    Dopamine enhances the vasoconstrictor reaction.

    Reduces the excretion of lithium from the blood plasma.

    Special instructions:

    Before an operation, an anesthesiologist must be warned about taking the drug.

    In the treatment it is not recommended to drive vehicles and work with moving mechanisms.

    Instructions
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