Included in the formulation
АТХ:S.01.H.A.03 Tetracaine
N.01.B.A.03 Tetracaine
Pharmacodynamics:Local anesthetic for surface anesthesia. It blocks voltage-dependent sodium channels, which prevents the generation of pulses in the endings of the sensory nerves and impulses along nerve fibers.
Anesthesia occurs 0.5-1.5 minutes after application to the surface of the mucosa and lasts for 15-20 minutes.
Pharmacokinetics:It is easily and completely absorbed through the mucous membranes (the rate of absorption depends on the site of administration and the dose). The binding with plasma proteins is high. Completely hydrolyzed mainly in plasma, cholinesterase for 1-2 hours with the formation of PABK-containing compounds and in the liver. It is excreted by the kidneys and with bile, while it is partially subjected to hepatic intestinal recirculation.
Indications:Terminal anesthesia (in adults and children over 10 years) with various endoscopic studies, for anesthesia with short-term operations and manipulations in dental, otorhinolaryngological, urological, gynecological practice.Conservative treatment of pain syndrome in superficial pathological processes.
XX.Y40-Y59.Y48.4 Painkillers, unspecified
XIX.T36-T50.T49.7 Poisoning by dental drugs used topically
Contraindications:Individual intolerance.
Carefully:Use with caution in case of skin and mucous membrane damage.
Pregnancy and lactation:Contraindicated in pregnancy and lactation.
Dosing and Administration:Locally. In endoscopic practice, the mucous membranes are immediately applied at 2 to 20 ml at a time immediately before the examination. In dentistry apply in the form of an application on the surface, subject to surgery, or on the affected area of the oral mucosa for 1-1.5 minutes. For relief of pain syndrome with conservative treatment of dental diseases, an application is made from 2-4 drops to 1-2 ml 3-4 times a day. In otorhinolaryngology - instillations or applications (1-1.5 minutes) immediately before the operation or manipulation in an amount of 2-4 drops to 1-2 ml. In gynecology - in the form of applications to the area of the mucous membrane, subject to surgical intervention, from 2-4 drops to 1-2 ml at a time.If necessary, during the surgical procedure, the applications are repeated, depending on the duration of the operation and individual tolerability of the drug to patients. The maximum dose of the drug in all cases should not exceed 30 ml per day.
Side effects:Slightly expressed unpleasant sensations in the place of application or instillation, allergic reactions.
Overdose:Treatment is symptomatic. Data on drug overdose are absent.
Interaction:Clinically significant interactions were not detected.
Special instructions:With prolonged use in ophthalmology, keratitis, persistent opacity of the cornea, scarring with loss of visual acuity, slowing of epithelialization are possible.