Dioxydin® (Dioxydin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspSolution for intracavitary and external use.
Composition:
Active substance: hydroxymethylquinoxaline dioxide (dioxidin) 10 mg.
Excipient: water for injection - up to 1 ml.
Description:Transparent greenish-yellow liquid.
Pharmacotherapeutic group:antimicrobial agent - quinoxaline
Pharmacodynamics:
A broad-spectrum antibacterial agent from the group of quinoxaline derivatives has chemotherapeutic activity in infections caused by Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp., Staphylococcus spp., Streptococcus spp., pathogenic anaerobes (Clostridium perfringens), acts on strains of bacteria resistant to other chemotherapeutics, including antibiotics.
Possible development of drug resistance of bacteria. Treatment of burns and purulent-necrotic wounds promotes faster cleaning of the wound surface, stimulates reparative regeneration and marginal epithelization and favorably influences the course of the wound process.
Pharmacokinetics:When topical application is partially absorbed from the wound or burn surface, it is excreted by the kidneys.
Indications:
Purulent bacterial infections caused by sensitive microflora when other chemotherapeutic agents are ineffective or poorly tolerated.
Intracavernal administration - purulent processes in the thoracic and abdominal cavities with purulent pleuritis, pleural empyema, lung abscess, peritonitis, cystitis, wound with the presence of deep purulent cavities (soft-tissue abscesses, phlegmon pelvic tissue, surgical wounds of the urinary and biliary tract purulent mastitis, and others. ), for the prevention of infectious complications after catheterization of the bladder.
External application - superficial and deep wounds of different localization, long-term healing wounds and trophic ulcers, soft tissue cellulitis, infected burns, festering wounds with osteomyelitis.
Contraindications:Individual drug intolerance, adrenal insufficiency (including history), pregnancy, lactation, infancy (up to 18 years).
Carefully:Renal failure.
Pregnancy and lactation:
During pregnancy and during breastfeeding, Dioxydin is contraindicated.
Dosing and Administration:
Dioxydin is prescribed in a hospital. Apply externally, intracavitary.
1% Dioxydin solution can not be used for intravenous administration, because of instability of the solution when stored at low temperatures.
Intracavitary injection. Depending on the size of the purulent cavity, 10 to 50 ml of a 1% solution of Dioxydin is administered per day. Dioxydin solution is injected into the cavity through a catheter, drain tube or syringe.
The maximum daily dose for administration in the cavity is 70 ml of a 1% solution.
The drug is injected into the cavity usually once a day. According to the indications, it is possible to administer a daily dose in two divided doses. With good tolerability, the drug can be administered daily for 3 weeks or more. If necessary, repeat courses are conducted after 1-1.5 months.
External application. Apply 0.1-1% solutions of Dioxydin. To obtain 0.1-0.2% solutions, ampoule solutions of the drug are diluted to the desired concentration with a sterile 0.9% solution of sodium chloride or water for injection. For the treatment of superficial infected purulent wounds, wipes moistened with 0.5-1% Dioxydin solution are applied to the wound. Deep wounds after treatment loosely swabbed with tampons moistened with 1% Dioxydin solution, and in the presence of a drainage tube, 20 to 100 ml of a 0.5% solution of the drug is injected into the cavity.
For the treatment of deep purulent wounds in osteomyelitis (brushes of the hand, feet) 0.5-1% solutions of the drug in the formtrays or special treatment of the wound with a solution of the drug for 15-20 minutes (insertion of the solution into the wound for this period), followed by the application of dressings with 1% Dioxydin solution. Dioxydin in the form of 0.1-0.5% solutions can be used to prevent and treat infection after surgery. According to the indications (patients with osteomyelitis) and with good tolerability, the treatment can be carried out daily for 1.5-2 months.
Side effects:When intracavitary administration may headache, chills, fever, diarrheal disorders, convulsive muscle contractions, allergic reactions, the photosensitizing effect (appearance of pigmented spots on the body when exposed to sunlight). With external application - okoloranevy dermatitis, itching.
Overdose:With an overdose of Dioxydin, the development of acute adrenal insufficiency is possible, which requires immediate withdrawal of the drug and appropriate hormone replacement therapy.
Interaction:With increased sensitivity to the drug, Dioxydin is used concomitantly with antihistamines or calcium preparations.
Special instructions:
Dioxydin is prescribed only to adults.Before the beginning of the course of treatment, a drug tolerance test is carried out, for which 10 ml of a 1% solution is injected into the cavity. If there are no side effects during 3-6 hours (dizziness, chills, fever), they begin course treatment.
Dioxydin is prescribed only for severe forms of infectious diseases or in the ineffectiveness of other antibacterial drugs, including cephalosporins of II-IV generations, fluoroquinolones, carbapenems.
In chronic renal failure, the dose is reduced.
When pigmented spots appear, the duration of dosing is increased to 1.5-2 hours, the dose is reduced, antihistamines are prescribed, or Dioxydin is canceled.
In the case of crystal precipitation during storage (at temperatures below 15 ° C), they are dissolved by heating the ampoules in a boiling water bath with shaking until the crystals are completely dissolved (clear solution). If the crystals do not fall again upon cooling to 36 - 38 ° C, the preparation is usable.
Effect on the ability to drive transp. cf. and fur:During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities,requiring increased concentration of attention and speed of psychomotor reactions.
Form release / dosage:Solution for intracavitary and topical application 10 mg / ml.
Packaging:
When manufactured at OAO Novosibkhimpharm
5 ml or 10 ml into neutral glass ampoules. By 3, 5 or 10 ampoules per contour cell packaging made of polyvinyl chloride film or polyethylene terephthalate tape and aluminum foil or paper with polyethylene coating or without foil, or without paper.
For 1 or 2 contour packs with instructions for use and a knife for opening ampoules or a scarifier ampullum in a pack of cardboard.
When you pack the ampoules with a break ring or break point, the ampoule opener or ampoule scapper is not put in.
In the production of OOO "FERMENT"
For 10 or 70 ml in bottles of a neutral transparent or dark glass.
For 1 bottle of 10 ml, along with instructions for use and a lid-dropper in a pack of cardboard.
For 1 bottle of 70 ml together with instructions for use in a pack of cardboard.
For 6, 8, 10 bottles of 70 ml with an equal number of instructions for use in the box of cardboard (for hospitals).
Storage conditions:
In the dark place at a temperature of 15 to 25 ° C.
Keep out of the reach of children.
Shelf life:2 years. Do not use after the expiration date.
Terms of leave from pharmacies:On prescription
Registration number:P N003934 / 01
Date of registration:02.08.2010
The owner of the registration certificate:VALENTA PHARM, PAO VALENTA PHARM, PAO Russia
Manufacturer: & nbsp
Information update date: & nbsp15.12.2015
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