Dioxydin is prescribed in a hospital. Apply externally, intravenously, intracaverally, endotracheally.
External application. Apply 0.1% - 0.5% solutions of dioxidine. To obtain 0.1-0.2% solutions, ampoule solutions of the drug are diluted to the desired concentration with a sterile isotonic sodium chloride solution or water for injection. For the treatment of superficial infected purulent wounds on the wound, apply salfets moistened with 0.5% dioxygen solution. Deep wounds after treatment, loose plugging with tampons moistened with 0.5% dioxygen solution, and in the presence of a drainage tube, 20 to 100 ml of a 0.5% solution of the drug is injected into the cavity.
For the treatment of deep purulent wounds with osteomyelitis (wounds of the hand,foot) apply 0.5% solution of the drug in the form of trays or special treatment of the wound with the solution of the drug for 15-20 minutes (insertion of the solution into the wound for this period), followed by application of dressings with a solution of dioxidine.
Dioxydin in the form of 0.1-0.5% solutions can be used to prevent infection after surgery. According to the indications (patients with osteomyelitis) and with good tolerability treatment can be carried out daily for 1.5-2 months.
Intracavitary injection. Depending on the size of the purulent cavity, 20% to 100 ml of a 0.5% solution (100-500 mg) of dioxidine are administered per day. Dioksidina solution is injected into the cavity through a catheter, drainage tube or syringe.
The maximum daily dose for administration in the cavity of 140 ml of a 0.5% solution (700 mg). The drug is injected into the cavity usually once a day. According to the indications, it is possible to administer a daily dose in two divided doses. With good tolerability and the presence of indications, the drug can be administered daily for 3 weeks or more. If necessary, repeat courses are conducted after 1-1.5 months.
Endotracheal administration. When diagnostic, sanative or therapeutic bronchoscopies use a 0.5% solution in an amount of 10-20 ml.For ultrasonic inhalations (in the treatment of purulent tracheobronchitis) a 0.5% solution is used in an amount of 10-20 ml.
Intravenous administration. Dioxydin is injected into the vein with a drop method of 0.5% solution, which is diluted with 5% dextrose solution or 0.9% sodium chloride solution to a concentration of 0.1-0.2%. The daily dose of the drug is administered once or in 3-4 divided doses (fractional administration).
Recommended doses of the preparation depending on the localization of the process:
1. In the treatment of a purulent urinary tract infection, a daily dose of 200-400 mg of dioxidine, i.e. 40-80 ml of 0.5% solution;
2. In chronic purulent processes in the lungs, the daily dose of 500-600 mg of dioxidine, i.e. 100-120 ml of a 0.5% solution;
3. With purulent meningitis, a daily dose of 600-700 mg of dioxidine, i.e. 120-140 ml of 0.5% solution.
4. In severe septic conditions, a 0.5% solution of the drug is injected intravenously intravenously, which is diluted in a 5% solution of dextrose or 0.9% solution of sodium chloride to a concentration of 0.1-0.2%. The daily dose of 600-900 mg (3-4 reception).