Dioxidept® (Dioxysept®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspsolution for intracavity and external administration
Composition:
Active substance: hydroxymethylquinoxaline dihydroxide (hydroxymethylquinoxylindioxide) - 10 mg
Excipient: water for injection-up to 1 ml
Description:
transparent greenish-yellow liquid.
Note. During the precipitation of crystals allowed snoring gidroksimetilhinoksalindioksida (gidroksimetilhinoksilindioksida) in ampules with the solution. In the case of deposition of crystals gidroksimetilhinoksalindioksida (gidroksimstilhinoksilindioksida) in ampoules of a solution dissolved by heating the vials with the solution in a boiling water bath with shaking until crystals dissolve (clear solution). If the crystals do not fall again upon cooling to 36-38 ° C, the preparation is usable.
Pharmacotherapeutic group:antimicrobial agent - quinoxaline
Pharmacodynamics:
Antibacterial bactericidal preparation of a wide spectrum of action. Active against Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Shigella dyscntcriae. Shigella flexncri, Shigella boydii. Shigella sonnei, Salmonella spp., Staphylococcus spp., Streptococcus spp., Pathogenic anaerobes (Clostridium perfringens). It acts on strains of bacteria resistant to other antimicrobial medicines, including antibiotics. Does not have a local irritant effect.
Possible development of drug resistance of bacteria.Treatment of burns and purulent-necrotic wounds promotes faster cleaning of the wound surface, stimulates reparative regeneration and marginal epithelization and favorably influences the course of the wound process.
In experimental studies, the presence of teratogenic, embryotoxic and mutagenic effects was demonstrated.
Pharmacokinetics:With external application partially absorbed from the wound or burn surface, excreted by the kidneys.
Indications:Purulent bacterial infections caused by sensitive microflora when other antimicrobial drugs are ineffective or poorly tolerated.
External application - wound and burn infection (superficial and deep purulent wounds of various locations, long-term healing wounds, trophic ulcers, soft tissue phlegmon, infected burns, purulent wounds in osteomyelitis).
Intracavernal administration - purulent processes in the thoracic and abdominal cavities: purulent pleurisy, empyema of the pleura, peritonitis, cystitis, prevention of infectious complications after catheterization of the bladder; wounds with the presence of deep purulent cavities (abscesses of soft tissues, phlegmon of the pelvic fat,postoperative wounds of the urinary and bile ducts, purulent mastitis).
Contraindications:
- individual intolerance;
- Adrenal insufficiency (including in the anamnesis);
- Children's age (up to 18 years).
Carefully:Renal failure.
Pregnancy and lactation:Contraindicated in pregnancy and during breastfeeding.
Dosing and Administration:
Method of application: externally, intracavitary.
External application. Apply 0.1-1% (1-10 mg / ml) solutions of Dioxidept® To prepare solutions of the desired concentration, the drug is diluted with a sterile 0.9% solution of sodium chloride or water for injection. To treat superficial infected purulent wounds on the wound, wipes moistened with 0.5-1% (5-10 mg / ml) with a solution of Dioxidept® are applied. Deep wounds after treatment, loose plugging with swabs moistened with 1% (10 mg / ml) solution of Dioxidept®.
To treat deep purulent paradise in osteomyelitis (brushes of the hand, foot), 0.5-1% (5-10 mg / ml) solutions of the drug in the form of trays or special treatment of the wound with a solution of the drug for 15-20 minutes (introduction to the wound solution for this period) followed by application of dressings with 1% (10 mg / ml) solution of Dioxyscept®.Dioxidept® in the form of 0.1-0.5% (1-5 mg / ml) solutions can be used to prevent infection after surgery. According to the indications (patients with osteomyelitis) and with good tolerability of the drug, treatment can be carried out daily for 1.5-2 months.
Intracavitary injection. In the cavity, depending on its size, 10 to 50 ml of 1% (10 mg / ml) solution of Dioxidept® is administered per day. A solution of Dioxidept® is injected into the cavity through a catheter, drain tube or syringe.
The maximum daily dose for administration in a cavity of 70 ml of 1% (10 mg / ml) solution.
The drug is injected into the cavity usually once a day. According to the indications, it is possible to administer a daily dose in two divided doses. With good tolerability and the presence of indications, the drug can be administered daily for 3 weeks or more. If necessary, repeat courses are conducted after 1-1.5 months.
For patients with impaired renal function and elderly patients, the dose of the drug is reduced by half.
Side effects:
Allergic reactions (rash, urticaria).
With intracavitary injection, headache, chills, fever, dyspeptic disorders, muscle cramps, photosensitizing effect (the appearance of pigmented spots on the body when exposed to sunlight) are possible.
With external application - okoloranevoy dermatitis, itching.
Interaction with other drugs
Information on the interaction of the drug with other medicinal products is absent
Overdose:With an overdose of Dioxidept®, the development of acute adrenal insufficiency is possible, which requires immediate discontinuation of the drug and appropriate hormone replacement therapy.
Special instructions:Before the beginning of the course of treatment, a drug tolerance test is performed, for which 10 ml of a 1% (10 mg / ml) solution is injected into the cavity. If there is no
3-6 h side effects (dizziness, chills, fever) begin course treatment. The drug is characterized by a narrow therapeutic breadth, so it is necessary to strictly follow the recommended dose, not allowing them to exceed.
The drug is prescribed only for severe forms of infectious diseases or in the ineffectiveness of other antibacterial drugs, including cephalosiorin II-IV generations, fluoroquinolones, carbaenems.
When pigmented spots appear, the duration of administration of a single dose is increased to 1.5-2 hours, the dose is reduced,prescribe antihistamines or cancel Dioxidept®.
Effect on the ability to drive transp. cf. and fur:Not studied.
Form release / dosage:
Solution for intracavitary administration and external application 10 mg / ml.
Packaging:
5 or 10 ml into neutral glass ampoules. For 10 ampoules, together with the instruction for use and the ampoule opening opener or ampoule scarifier, is placed in a cardboard box.
5 ampoules in the outline of the cell. 2 contour mesh packages together with the instructions are placed in a pack of cardboard.
When using ampoules with notches, rings and dots, the ampoule opener or the ampoule scarifier may not be inserted.
Storage conditions:
In the dark place at a temperature of 15 to 25 ° C.
Keep out of the reach of children.
Shelf life:2 years. Do not use after the expiration date printed on the package.
Terms of leave from pharmacies:On prescription
Registration number:LS-001373
Date of registration:30.11.2011
The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
Manufacturer: & nbsp
Information update date: & nbsp18.03.2016
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