For use only in conditions of a specialized treatment and prophylactic institution, taking into account the inpatient and outpatient stages.
Before administering Eberprot-P®, personnel working with it should be properly washed and put on sterile gloves. The drug Eberprot-P® is applied at the rate of one vial per patient. The wound surface should be cleaned with sterile physiological solution and dry sterile gauze wipes. The area of the lesion focus should be measured (in cm2).
The Eberprot-P® vials contain a lyophilized white powder.Before use, five milliliters of water for injections are added to the vial, after which it is gently stirred for a few seconds. The solution prepared in this way should be clear and colorless, without visible particles. The resulting solution should be used immediately after preparation. If any solid particles are noted in the solution or if the appearance of the solution is different from that described above, the reconstituted product should not be used; it must be properly disposed of.
The contents of each vial with Eberprote-P® are reconstituted by adding 5 ml of solution for injection; using the resulting solution, up to ten injections containing 0.5 ml of the solution can be carried out. The syringe must be equipped with a needle 26Gx1/2"or with a needle 24Gx11/2", for small or deep injections, respectively.
For the treatment of ulcers larger than 10 cm2 should make ten injections of 0.5 ml. Injections should be done in soft tissues with a uniform distribution of the injection site, first of all, by cutting the edges of the wound, and then the bed of the wound (see the figure below). The depth of needle insertion during injection should be about 0.5 cm.
For the treatment of wounds with an area of less than 10 cm2 per cm2 of the area of the lesion focus, use only one injection in a volume of 0.5 ml of Eberprot-P. For example, to treat a 4 cm wound2 Only four injections of 1.25 ml of the drug should be performed.
To reduce the risk of infection, each injection should be done with a new sterile needle.
After the injections are completed, the ulcer should be covered with gauze moistened with saline, or a moist bandage applied to create a moist and clean environment.
Splitting is carried out 3 times a week. Injections of Eberproth-P® should be continued until the formation of granulation tissue covering the entire surface of the wound, or up to 8 weeks (maximum duration of treatment).
The wound surface should be covered with a neutral atraumatic bandage.
If after three weeks of treatment with Eberprot-P® the granulation tissue in the wound does not begin to form, the presence of a local infection or osteomyelitis should be excluded.