EGYPTENIN Capsules are taken orally, regardless of food intake. The capsule should be swallowed whole, with enough liquid.
If it is necessary to reduce the dose, cancel the drug or replace it with an alternative remedy, this should be done gradually for at least one week.
With partial seizures for adults and children over the age of 12, the effective dose is from 900 mg to 3600 mg per day. Therapy can begin with a dose of 300 mg 3 times a day on the first day or increase gradually to 900 mg according to the scheme:
1 day - 300 mg of the drug once a day;
Day 2 - 300 mg twice a day;
Day 3 - 300 mg 3 times a day.
Subsequently, the dose can be increased to a maximum of 3600 mg per day (divided into 3 equal doses). A good tolerability of the drug at doses up to 4800 mg / day was noted.The maximum interval between doses with a three-time intake of the drug should not exceed 12 hours in order to avoid the resumption of seizures.
For children aged 3-12 years, the initial dose of the drug varies from 10 to 15 mg / kg per day, the frequency of administration is 3 times a day in equal doses, the increase to the effective dose is carried out for approximately 3 days. The effective dose in children aged 5 years and older is 25-35 mg / kg per day in equal doses in 3 divided doses. Effective dose EGYPTENIN in children aged 3 to 5 years is 40 mg / kg per day in equal doses in 3 divided doses. A good tolerability of the drug in doses up to 50 mg / kg per day with long-term use was noted. The maximum interval between taking doses of the drug should not exceed 12 hours in order to avoid the resumption of seizures.
There is no need to monitor the concentration of gabapentin in plasma. EGYPTENIN can be used in combination with other anticonvulsants without taking into account changes in plasma concentration or concentration of other anticonvulsants in serum.
With neuropathic pain, adults are prescribed in an initial dose of 900 mg / day in 3 divided doses. If necessary, depending on the effect, the dose gradually (300 mg per day every 2-3 days) is increased to a maximum of 3600 mg / day.The minimum time to achieve a dose of 1800 mg per day is 1 week, to achieve a dose of 2,400 mg per day, it takes 2 weeks, and to achieve a dose of 3600 mg per day, it takes 3 weeks. Some patients may need a slower titration.
Treatment can begin immediately with a dose of 900 mg / day (300 mg 3 times a day) or within the first 3 days the dose can be increased gradually to 900 mg / day as follows:
1 day - 300 mg of the drug once a day;
Day 2 - 300 mg twice a day;
Day 3 - 300 mg 3 times a day.
The effectiveness of this drug has not been studied in the treatment of neuropathic pain for more than 5 months. If the patient needs to take the drug for more than 5 months, the attending physician should assess the clinical condition of the patient and determine the need for additional therapy.
If the patient's general condition is poor, for example, at a low body weight, after organ transplantation, etc., titration of the dose should be performed more slowly, using lower doses or longer intervals between dose increases.
The elderly patients (over 65 years of age) according to the age-related decrease in QC, patients with renal insufficiency (CC less than 80 ml / min), as well as patients on hemodialysis,The therapeutic dose should be selected individually.
Recommended doses of gabapentin for renal dysfunction.
| Creatinine clearance (ml / min) | The daily dose of gabapentin (mg) * |
| > 80 ml / min | 900-2400 |
| 50-79 | 600-1800 |
| 30-49 | 300-900 |
| 15-29 | 150**-600 |
| <15 | 150**-300 |
* The daily dose should be divided into 3 doses
** take 300 mg every other day
Patients who are on hemodialysis and have not previously taken
gabapentin, it is recommended to appoint a saturating dose equal to 300-400 mg, then every 4 h of hemodialysis session, appoint 200-300 mg of the drug.
In days free from dialysis, EGYPTENIN can not be accepted.
Capsules should be taken orally, without chewing and washing down with the necessary amount of liquid, regardless of food intake.