Elsulphavirin (Elsulfavirine)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Antiviral drugs

Included in the formulation
  • Elpida®
    capsules inwards 
    Viriom, Open Company     Russia
    • АТХ:

    J.05.A.G.   Non-nucleosides - reverse transcriptase inhibitors

    Pharmacodynamics:

    A prodrug is metabolized in the liver to a non-nucleoside reverse transcriptase inhibitor of the human immunodeficiency virus. Active with HIV-1 reverse transcriptase. It does not interact with HIV-2 reverse transcriptase and human α, β, γ and δ DNA polymerase.

    Pharmacokinetics:

    After oral administration, an empty stomach is absorbed up to 80% in the gastrointestinal tract. The maximum concentration of the active metabolite in the blood plasma is achieved after 3.5 hours. Deposited in blood cells.

    Metabolism in the liver by hydroxylation followed by glucuronidation to aminosulfonamide.

    The half-life is 7-9 days. Elimination with feces.
    Indications:

    It is used to treat HIV-1 infection in combination antiretroviral therapy.

    ICD-10

    I.B20-B24   Disease caused by the human immunodeficiency virus [HIV]

    Contraindications:

    Age to 18 years, pregnancy and lactation, individual intolerance.

    Carefully:

    Severe anemia, liver failure, hypersensitivity.

    Pregnancy and lactation:Contraindicated in pregnancy and lactation.
    Dosing and Administration:

    Inside, 15 minutes before meals, 20 mg once a day.

    The highest daily dose: 20 mg.

    The highest single dose: 20 mg.

    Side effects:

    Central and peripheral nervous system: dizziness, anxiety, asthenia, sleep disturbance, depression, paresthesia, syncope, rarely - irritability, nightmares.

    Respiratory system: shortness of breath, cough, rhinorrhea.

    Hemopoietic system: leukopenia, neutropenia.

    Digestive system: a violation of taste sensitivity, dry mouth, vomiting, belching, rarely - abdominal pain.

    Dermatological reactions: herpes, fungal infections.

    Sense organs: tinnitus, hyperacia, impaired sense of smell.

    Musculoskeletal system: arthralgia.

    Dermatological reactions: itching, rash, rarely - alopecia.

    urinary system: proteinuria, leukocyturia, rarely - urolithiasis.

    Reproductive system: dysmenorrhea, sexual dysfunction.

    Allergic reactions.

    Overdose:

    Anxious state, drowsiness, convulsive syndrome, indomitable vomiting.

    Treatment is symptomatic.

    Interaction:

    Inactivated by the action of products with acid reaction, including orange and apple juice.

    Strengthens the effect of reverse transcriptase inhibitors.

    Increases the level of plasma concentrations of astemizole, saquinavir, indinavir, terfenadine, cisapride, slow calcium channel blockers, prolongs the sedative effect of tranquilizers.

    Reduces the level of concentration in the blood plasma contraceptives: norethindrone and ethinyl estradiol.

    Special instructions:

    If you skip the drug less than 6 hours before the prescribed time, it is recommended to take the drug as early as possible. With an interval of more than 6 hours - at the set time.

    During treatment and 12 weeks after its end, it is recommended to use reliable barrier methods of contraception.

    When taking the drug is not recommended driving and working with moving machinery.

    Instructions
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