According to the data obtained during clinical trials, after the introduction of the vaccine, it is possible to develop local and general reactions that occurred primarily on the first administration of the vaccine and were performed independently without the appointment of specific therapy for a period of several hours to several days (2-4 day).
Local reactions are expressed in redness, swelling, tenderness at the injection site.
General reactions develop in the form of malaise, drowsiness, increased fatigue, headache, dizziness, nausea, abdominal pain, myalgia, fever to 38.5 ° C.
Perhaps the development of allergic reactions.
If the patient is not well tolerated at elevated temperature (up to 38.5 ° C), symptomatic therapy is performed.
Based on the data obtained from the clinical study of the vaccine, the following information was obtained on the incidence of adverse reactions:
Very often (≥1 / 10) - pain in the injection site.
Often (1/10 - 1/100) - Hyperemia at the injection site, swelling at the injection site, fever to 38.5 ° C (especially for the first vaccination), taking place for 1-4 days, headache, weakness, malaise, fatigue, drowsiness, abdominal pain, myalgia .
Sometimes (1/100 - 1/1000) - nausea, dizziness.
Rarely (1/1000 - 1/10000) - allergic reactions of immediate and delayed types.
Very rarely (<1 / 10,000) marked neurological symptoms.
The permissible frequency for general reactions with a temperature above 37.5 ° C is not more than 4%.