Active substanceEtamsylateEtamsylate
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  • Dosage form: & nbsppills
    Composition:1 tablet contains:

    active substance: ethamylate 0.25 g;

    Excipients: calcium phosphate dihydrate, sodium pyrosulfate, potato starch, polyvinylpyrrolidone, calcium stearate.

    Description:Tablets are white or white with a cream or pinkish hue, slightly marble, flat-cylindrical, with a risk.
    Pharmacotherapeutic group:hemostatic agent
    ATX: & nbsp

    B.02.B.X.01   Etamsylate

    Pharmacodynamics:

    The drug has a haemostatic effect, has an angioprotective and proaggregant effect. Stimulates the formation of platelets and their exit from the bone marrow.

    Hemostatic action is due to the activation of thromboplastin formation at the site of damage to small vessels and a decrease in the formation of prostacyclin vessels in the endothelium. This helps to increase the adhesion and aggregation of platelets, which ultimately leads to stopping or reducing bleeding.

    Increases the rate of formation of the primary thrombus and strengthens its retraction, practically does not affect the level of fibrinogen and prothrombin time. Doses of more than 2-10 mg / kg do not lead to greater severity of the effect. With repeated injections, thrombus formation is intensified.

    Possessing anti-hyaluronidase activity and stabilizing ascorbic acid, it prevents destruction and promotes the formation in the capillary wall of mucopolysaccharides with a large molecular weight, increases the resistance of capillaries, reduces their fragility, normalizes the permeability of the latter in pathological processes.

    Reduces the yield of fluid and diapedesis of blood elements from the vascular bed, improves microcirculation.

    Has no hypercoagulable properties, does not have vasoconstrictive effect.

    When administered, the maximum effect is observed after 2-4 hours.

    Pharmacokinetics:

    It is well absorbed after ingestion. The effective concentration in the blood is 0.05-0.02 mg / ml. The maximum effect is observed after 2-4 hours. Etamsylate little associated with plasma proteins and shaped elements of blood. It is evenly distributed in various organs and tissues (depends on the degree of their blood supply).

    Excretion from the body occurs quickly, mainly with urine, and also with bile practically unchanged.

    Indications:

    Parenchymal and capillary hemorrhages, secondary bleeding against thrombocytopenia and thrombocytopathy, prevention of intra- and postoperative bleeding (for vascular surgery and highly vascularized tissue), diabetic microangiopathies: hemorrhagic diabetic retinopathy, repeated retinal hemorrhage, hemophthalmia, epistaxis in hypertension, hemorrhagic syndrome on the background of taking ascorbic acid and anticoagulants of indirect action.

    With diseases of the blood system, hematuria, intestinal and pulmonary hemorrhages, hemorrhagic vasculitis, intracranial hemorrhages, incl. in newborns and premature infants, for the prevention and treatment of hemorrhages in the eyes; hemorrhagic diathesis: a disease of Verlhof, Willebrand-Jurgens, metro, menorrhagia, internal traumatic bleeding.

    Contraindications:

    - Hypersensitivity to the components of the drug;

    - hemorrhages against the background of anticoagulants;

    - thrombosis;

    - thromboembolism;

    acute porphyria.

    Dosing and Administration:

    Etalesylate is prescribed once and in courses of 5-14 days, repeated courses at intervals of 7-10 days.

    A single dose for adults: inside - 0,25-0,5 g, if necessary, can be increased to 0.75 g.

    Adults: with operative interventions per day inside regardless of food intake, 0.5-0.75 g (2-3 tablets) every 4-6 hours; after surgery, if there is a danger of bleeding inwards, 0.5 g (2 tablets) 3-4 times / day.

    With intestinal, pulmonary hemorrhages - 0.5 g (2 tablets) inside for 5-10 days, with the continuation of the course of treatment, the dose is reduced; Pmetro and menorrhagia the same dose in the bleeding period and 2 subsequent cycles.

    With hemorrhagic diathesis, diseases of the blood system, diabetic angiopathy, etc.. prescribe courses 5-14 days inside at 0.75-1 g (3-4 tablets) / day at regular intervals.

    Diabetic microangiopathies: 1-2 tablets 3 times / day for 2-3 weeks.

    Children appoint a dose of 0.01-0.015 g / kg body weight per day for 3 doses.
    Side effects:

    Heartburn, a feeling of heaviness in the epigastric region, headache, dizziness, facial skin hyperemia, arterial hypotension (mainly systolic), paresthesia of the lower extremities, allergic reactions.

    Overdose:

    In the recommended doses and methods of administration, the drug does not cause intoxication and overdose.

    Interaction:

    The combination with aminocaproic acid, vikasol, anticoagulant preparations is acceptable.

    Reduces the severity of the course of hemorrhagic syndrome caused by acetylsalicylic acid and anticoagulants of indirect action.

    Special instructions:

    Caution is necessary (despite the lack of support for the formation of blood clots) in the administration of etamzilate to patients with thrombosis or embolism in the history.

    When hemorrhagic complications associated with an overdose of anticoagulants, it is necessary to use specific antidotes.

    Etalesylate is prescribed only as an auxiliary and, mainly, in the violation of platelet-vascular components of hemostasis.

    Form release / dosage:Tablets, 0.25 g.
    Packaging:

    For 30, 40, 50 tablets in a can of orange glass, in a jar and a bottle of glass.

    For 30, 40, 50 tablets in a plastic container of low pressure polyethylene or high pressure, into a plastic bottle.

    For 10 tablets in a planar cell package.

    One can, a container, a vial, 1 or 2 contiguous cell packs in a bundle.

    Storage conditions:

    Store in a dry place protected from light.

    The drug should be stored in places inaccessible to children.

    Shelf life:

    3 years.

    Do not use the product after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N002289 / 01-2003
    Date of registration:31.07.2008
    The owner of the registration certificate:BRYNTSALOV-A, CJSC BRYNTSALOV-A, CJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspBRYNTSALOV-A, CJSCBRYNTSALOV-A, CJSC
    Information update date: & nbsp05.10.2015
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