Included in the formulation
АТХ:N.05.B.X Other anxiolytics
N.05.B.X.03 Ethifoxine
Pharmacodynamics:Anxiolytic (tranquilizer).The benzoxazine derivative has anxiolytic activity, and to a lesser extent has a sedative effect. Selectively affects the chlorine canals of supramolecular GABA-benzodiazepine-chloro-ionophore receptor complex, inhibiting GABA-ergic transmission.
Does not cause addiction and withdrawal symptoms.
Pharmacokinetics:After oral administration, it is rapidly absorbed from the digestive tract. The time to reach the maximum concentration in the blood is 2-3 hours. It penetrates the placental barrier. Rapidly metabolized in the liver before the formation of several metabolites. One of the metabolites, diethyl ethylfoxine, is active. The half-life of etifoxine is about 6 hours, half-life active metabolite - 20 hours. It is excreted mainly with urine in the form of metabolites and in small amounts in unchanged form; also excreted with bile.
Indications:Elimination of anxiety, fear, internal tension, increased irritability, decreased mood (including somatic diseases, especially cardiovascular nature).
V.F40-F48.F45.0 Somatic Disorder
V.F40-F48.F45.3 Somatoform dysfunction of the autonomic nervous system
V.F60-F69.F60.3 Emotionally unstable personality disorder
XVIII.R40-R46.R45.0 Nervousness
XVIII.R40-R46.R45.4 Irritability and anger
XVIII.R40-R46.R45.7 Condition of emotional shock and stress, unspecified
Contraindications:Shock states; myasthenia gravis; severe violations of liver function; severe renal dysfunction; children and adolescents under 18; increased sensitivity to etifoksin.
Carefully:Lactose may be present in the dosage forms, which should be taken into account when prescribing the drug to patients with galactosemia, glucose malabsorption syndrome and galactose, and also in the case of lactase deficiency.
Pregnancy and lactation:The use of the drug during pregnancy and during breastfeeding is contraindicated.
If pregnancy is detected during treatment with etifoxine, you should consult your doctor about continuing treatment.
Dosing and Administration:Dose and duration of treatment the doctor determines individually, depending on the patient's condition.
Ingest, as a rule, 50 mg 3 times a day or 100 mg 2 times a day. The course of treatment usually ranges from a few days to 4-6 weeks.
Side effects:From the side CNS: insignificant drowsiness, which appears in the first days of admission and usually disappears on its own during the treatment.
Allergic reactions: rarely - skin rashes, hives, swelling of the Quincke.
Overdose:Symptoms: lethargy, excessive drowsiness.
Treatment: gastric lavage with plenty of water, symptomatic treatment. There is no specific antidote.
Interaction:Potentiates the effect of drugs that depress the central nervous system (including opioid analgesics, barbiturates, hypnotics, antihistamines, neuroleptics).
Ethifoxine enhances the effect of ethanol.
Special instructions:In case of missed admission, do not double the dose at the next admission.
During the treatment is not recommended the use of alcohol.
Due to the risk of drowsiness, vehicle management should be avoided and activities requiring increased attention, for example, management of various mechanisms.